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HomeGeneral BooksZoonosesHuman and Animal Filariases, Landscape, Challenges, and Control

Human and Animal Filariases, Landscape, Challenges, and Control [PDF Download]

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Human And Animal Filariases, Landscape, Challenges, And Control Pdf Download

By Ronald Kaminsky, Timothy G. Geary and Paul M. Selzer

Human and Animal Filariases, Landscape, Challenges, and Control. Filariae are a family of parasitic worms which infect animals and humans, causing severe diseases such as elephantiasis (lymphatic filariasis) and river blindness (onchocerciasis) in humans, as well as heartworm disease (dirofilariasis) in dogs and cats. While the human diseases are rarely fatal, the blindness and disfiguration resulting from these infections constitute a severe burden for the affected individuals and to the healthcare systems in many tropical countries. In 2017, the World Health Organization classified several filariases as neglected tropical diseases and announced a new program seeking to eradicate these infections, which has in turn sparked a new push to develop antifilarial drugs.

Considering the current and future import of this topic, Human and Animal Filariases takes a comprehensive look at infections by filarial parasites in humans and in animals. It begins by reviewing the current state of diagnosis and chemotherapy, before addressing the increasing resistance to available antifilarial drugs. This is followed by strategies and approaches for the discovery of novel drugs and finally by looking at alternative and supplementary approaches to combat the parasites, including vector control and vaccination.

Human and Animal Filariases is a unique reference for parasitologists, veterinarians, as well as professionals in the pharmaceutical industry and in public health agencies.

Features

Features:

  • A comprehensive approach that integrates current chemotherapy with recent advances in antifilarial drug discovery
  • Practical information on assay development, target validation, and required drug product profiles
  • Insights from global experts from leading academic institutions as well as from pharma and healthcare companies
Table of Contents

Table of Contents:

  • Part I: Human and Animal Filariae and Their Diseases

    • Breaking the Silos โ€“ Obstacles and Opportunities for One Health in Filariases

    • Filariae as Organisms

    • Human Filarial Infections: Reflections on the Current Understanding of Their Importance, Pathobiology, and Management

    • Canine Filariasis (Heartworm) โ€“ Disease and Current Gaps

    • Diagnosis and Assessment of Human Filarial Infections: Current Status and Challenges

    • Veterinary Diagnosis of Filarial Infection

    • Antifilarial Chemotherapy: Current Options for Humans

    • Antifilarial Chemotherapy: Current Options in Veterinary Medicine

    • Heartworm Disease โ€“ Intervention and Industry Perspective

    • Current Antifilarial Drugs โ€“ Mechanisms of Action

    • Drug Resistance in Filariae

    • Elimination and Eradication of Human Filariases

  • Part II: Drug Discovery for Novel Antifilarials

    • Global Economics of Heartworm Disease

    • Product Profiles for New Drugs Against Human and Animal Filariasis

    • Discovery and Development of New Antifilarial Drugs (In Vitro Assays)

    • In Vivo Models for the Discovery of New Antifilarial Drugs

    • In Vivo Assays โ€“ Discovery and Development of New Antifilarial Drugs in Companion Animals

    • The Antifilarial Drug Pipeline

  • Part III: New Frontiers for Control of Antifilarial Diseases

    • The Hostโ€“Helminth Interface as a Rich Resource for Novel Drug Targets

    • Functional Genomics of Filariae

    • Development of a Vaccine Against Onchocerca volvulus

    • Vector Control Approaches to Interrupt Transmission of Human Filarial Parasites

    • Vector Control Approaches for Canine Filariasis

    • Wolbachia Endosymbionts as Treatment Targets for Filarial Diseases

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