Handbook of Venoms and Toxins of Reptiles, 2nd Edition

Handbook of Venoms and Toxins of Reptiles, 2nd Edition

By Stephen P. Mackessy

A decade after publication of the first edition, the Handbook of Venoms and Toxins of Reptiles PDF responds to extensive changes in the field of toxinology to endure as the most comprehensive review of reptile venoms on the market. The six sections of this new edition, which has nearly doubled in size, complement the original handbook by presenting current information from many of the leading researchers and physicians in toxinology, with topics ranging from functional morphology, evolution and ecology to crystallography, -omics technologies, drug discovery and more. With the recent recognition by the World Health Organization of snakebite as a neglected tropical disease, the section on snakebite has been expanded and includes several chapters dealing with the problem broadly and with new technologies and the promises these new approaches may hold to counter the deleterious effects of envenomation.

This greatly expanded handbook offers a unique resource for biologists, biochemists, toxicologists, physicians, clinicians, and epidemiologists, as well as informed laypersons interested in the biology of venomous reptiles, the biochemistry and molecular biology of venoms, and the effects and treatment of human envenomation.

Table of Contents

Section I: Introduction and Technologies Used in Toxinology

1. Reptile venoms and toxins: Unlimited opportunities for basic and applied research – Stephen P. Mackessy

2. Present and future of snake venom proteomics profiling – Juan J. Calvete and Bruno Lomonte

3. Applications of genomics and related technologies for studying reptile venoms – Drew R. Schield, Blair W. Perry, Giulia I.M. Pasquesi, Richard W. Orton, Zachary L. Nikolakis, Aundrea K. Westfall, Todd A. Castoe

4. Snake venom gland transcriptomics – Cassandra M. Modahl and Rajeev Kungur Brahma

5. X-ray crystallography and structural studies of toxins – Vinícius Lucatelle da Silva, Ricardo Barros Mariutti, Mônika Aparecida Coronado, Raphael Josef Eberle, Fábio Rogério de Moraes and Raghuvir Krishnaswamy Arni

6. Envenomations and Treatment: Translating between the bench and the bedside – Nicklaus Brandehoff and Jordan Benjamin

7. Current assessment of the state of snake venom toxinological research with a view to the future – Sarah Natalie Cirilo Gimenes and Jay W. Fox

Section II: Venom Gland Structure, Systematics and Ecology

8. Reptile venom glands: Form, function, future, concepts and controversies – Scott A. Weinstein

9. Advances in venomous snake systematics, 2009-2019 – Wolfgang Wüster

10. Biochemical ecology of venomous snakes – Cara F. Smith and Stephen P. Mackessy

11. Resistance of native species to reptile venoms –– Danielle H. Drabeck

Section III: Reptile Venom Non-enzymatic Toxins

12. Three-finger toxins – Rajeev Kungur Brahma, Cassandra M. Modahl and

R. Manjunatha Kini

13. Myotoxin a, crotamine and defensin homologs in reptile venoms – Lucas C. Porta, Pedro Z. Amaral, Paulo Z. Amaral and Mirian A. F. Hayashi

14. Reptile venom disintegrins – Anthony J. Saviola and Juan J. Calvete

15. Reptile venom cysteine-rich secretory proteins – María Elisa Peichoto and Marcelo Larami Santoro

16. Bradykinin-potentiating and related peptides from reptile venoms – Daniel Carvalho Pimenta and Patrick Jack Spencer

17. Exendins and its related proteins – Michelle Khai Khun Yap and Nurhamimah Misuan

18. Reptile venom C-type-lectins – Kenneth J. Clemetson

19. Snake venom Kunitz-type inhibitors and cystatins – structure and function – Elda E. Sánchez, Emelyn Salazar, Montamas Suntravat and Francisco Torres

20. Small molecular constituents of snake venoms – Alejandro Villar-Briones and Steven D. Aird

21. Cobra venom factor: Structure, function, biology, research tool and drug lead – Carl-Wilhelm Vogel, Brian E. Hew and David C. Fritzinger

22. Snake toxins targeting diverse ion channels – Matan Geron and Avi Priel

Section IV: Reptile Venom Enzyme Toxins

23. Thrombin-like serine proteinases in reptile venoms – Stephen D. Swenson, Samantha Stack

and Francis S. Markland Jr.

24. Snake venom metalloproteinases  – Charlotte A. Dawson, Stuart Ainsworth, Laura-Oana Albulescu and Nicholas R. Casewell

25. Snake venom matrix metalloproteinases (svMMPs): Alternative proteolytic enzymes in rear-fanged snake venoms – Inácio L. M. Junqueira-de-Azevedo and Juan David Bayona-Serrano

26. Snake venom phospholipase A2 toxins – Bruno Lomonte and Igor Križaj

27. Reptile venom L-amino acid oxidases – structure and function – Juliana P. Zuliania, Mauro V. Paloschi, Adriana S. Pontes, Charles N. Boeno, Jéssica A. Lopes, Sulamita S. Setubal, Fernando B. Zanchi and Andreimar M. Soares

28. Snake venom nucleases, nucleotidases, and phosphomonoesterases – Jüri Siigur and Ene Siigur

29. Reptile venom acetylcholinesterases – Mushtaq Ahmed, Wasim Ahmad, Nadia Mushtaq,

Rehmat Ali Khan and Maria Rosa Chitolina Schetinger

30. Inhibitors of reptile venom toxins – Ana F. Gómez Garay, Jorge J. Alfonso, Anderson M. Kayano, Juliana C. Sobrinho, Cleopatra A. S. Caldeira,  Rafaela Diniz-Sousa, Fernando B. Zanchi, Juliana P. Zuliani, and Andreimar M. Soares

Section V: Global Approaches to Envenomations and Treatments

31. Snakebite envenomation as a neglected tropical disease: new impetus for confronting an old scourge – José María Gutiérrez

32. Current industrial production of snake antivenoms – Mariángela Vargas, Melvin Sánchez, Andrés Hernández, Aarón Gómez, Mauricio Arguedas, Andrés Sánchez, Laura Sánchez, Mauren Villalta, María Herrera and Álvaro Segura

33. Antivenom in the age of recombinant DNA technology – Andreas H. Laustsen

34. Epidemiology and treatment of reptile envenomations in the United States – Daniel E. Keyler and Nicklaus Brandehoff

35. Envenomations by reptiles in México – Edgar Neri-Castro, Melisa Bénard-Valle, Jorge López de León, Leslie Boyer and Alejandro Alagón

36. Snakebite envenomation in Central America: Epidemiology, pathophysiology and treatment – José María Gutiérrez

37. Snakebite in Southeast Asia: Envenomation and clinical management– Nget Hong Tan, Kae Yi Tan and Choo Hock Tan

38. Snake envenomation: Therapy and challenges in India – Ashis K. Mukherjee, Bhargab Kalita, Sumita Dutta, Aparup Patra, Chitta R. Maiti and Dileep Punde

39. Snakebite in Africa: Current situation and urgent needs – Jean-Philippe Chippaux

40. Approaches to snake envenomation in Southern Africa – James Pattinson, George Oosthuizen, Colin R. Tilbury and Darryl Wood

Section VI: Reptile Venoms – Production and as a Source of Therapeutics

41. Large-scale snake colonies for venom production: Considerations and challenges – Kristen L. Wiley and James R. Harrison

42. Toxins to drugs – biochemistry and pharmacology – Zoltan Takacs

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