A Practical Guide to Seizure Disorders in Dogs and Cats

A Practical Guide to Seizure Disorders in Dogs and Cats

By Luisa De Risio and Karen Muñana

A Practical Guide to Seizure Disorders in Dogs and Cats eBook Download. Seizure disorders are commonly encountered in small animal practice. The goal of this book is to provide a comprehensive, evidence-based resource to assist in the successful management of recurrent seizures in dogs and cats. Practical information on every aspect of seizure management is presented and is supported with a review of the available literature. The book’s format is designed to provide a logical, clinically relevant approach to the seizure patient, with in-depth information on the broad range of topics involved in the diagnosis and treatment of seizure disorders in dogs and cats. The first five chapters describe the clinical and diagnostic approach to the seizure patient, and include thorough descriptions of seizure classification with video case examples, canine idiopathic epilepsy, the genetics of epilepsy, feline epilepsy and quality of life. There are separate chapters devoted to advanced imaging and electroencephalography, both of which contain numerous images to complement the discussion of the material. The remaining chapters focus on epilepsy treatment and include a review of general treatment guidelines and pharmacological principles, as well as a comprehensive review of antiseizure drugs, adjunctive therapies for drug-resistant epilepsy, and the management of cluster seizures and status epilepticus in dogs and cats. The 19 book chapters are authored by veterinary specialists from around the globe. Algorithms are included throughout the book, and each chapter contains a summary of key points, providing easy access to information to support clinical decision making and patient care. Our aim was to create a comprehensive reference that would be of value to primary care veterinarians, veterinary students, interns, residents, and veterinary specialists alike.

Table of Contents

01 The Clinical and Diagnostic Approach to the Seizure Patient

Luisa De Risio, Karen R. Muñana


Phases associated with a seizure

Disorders that can mimic seizures and discriminators

Systematic diagnostic approach to the patient with seizure disorders

02 Canine Idiopathic Epilepsy

Andrea Fischer

Types of epileptic seizures

Diagnostic approach

Breed-related differences

and lifespan in canine idiopathic epilepsy

03 Quality of Life Issues in Canine Epilepsy

Rowena MA Packer

What is quality of life?

Impact of epilepsy on canine QoL

Impact of epilepsy on caregiver quality of life

04 Genetics of Epilepsy in Dogs and Cats

Edward (Ned) E. Patterson

Genetic or suspected genetic idiopathic epilepsy in dogs

Structural epilepsies in dogs

L-2-Hydroxyglutaric aciduria

Genetic counseling for breeding dogs with epilepsy

Feline epilepsy genetics

05 Feline Epilepsy

Akos Pakozdy, Borbala A. Lörincz

Prevalence of seizure disorders in cats


Diagnostic approach to seizure disorders in cats

Antiseizure treatment of feline epilepsy

Outcome of feline epilepsy.

06 Advanced Diagnostic Imaging in Epilepsy

Daisuke Hasegawa

Conventional MRI

Structural MRI for diagnosis of epilepsy

Advanced and functional imaging

Imaging findings of structural epilepsies

Degenerative diseases

07 Electroencephalography

Fiona M.K. James

How does EEG work?

How to record EEG?

How to interpret EEG?

How to report EEG?

Where to learn more on EEG?

08 Fundamental Principles of Pharmacokinetics for Antiseizure Medications

Mark G. Papich

Important definitions

Principles of drug disposition in animals

Drug elimination (elimination half-life, t½)

Drug distribution (volume of distribution)

Drug clearance

Drug absorption

09 Principles of Antiseizure Drug Use

Karen R. Muñana, Luisa De Risio

Initiating therapy

Choosing an appropriate antiseizure drug

Devising a rational treatment plan

Drug resistance

Epilepsy remission

10 Phenobarbital

Fabio Stabile, Luisa De Risio

Mechanism of action



Clinical use

Adverse effects and drug interactions

11 Potassium Bromide

Michael Podell

Mechanism of action



Clinical use

Adverse effects and drug interactions

12 Levetiracetam

Karen R. Muñana

Mechanism of action



Clinical use

13 Imepitoin

Andrea Tipold

Mechanism of action



Clinical use

Adverse effects and drug interactions

14 Zonisamide

Daisuke Hasegawa, Miyoko Saito

Mechanism of action


Clinical use

Adverse effects and drug interactions

15 Other Antiseizure Drugs

Kari Foss, Devon Hague

Clorazepate and Clonazepam








16 Cannabidiol in Canine Epilepsy

Stephanie McGrath

Mechanism of Action



Clinical use

Adverse effects and drug interactions

17 Dietary Management of Canine Epilepsy

Elliott S. Neal, Weizhi Xu, Karin Borges

Pathophysiology and mechanism of action.

“Pharmacology and pharmacokinetics” of ketogenic diets and medium chain triglycerides Efficacy

Manipulations of macronutrients – practical considerations for the treatment of dogs with epilepsy

18 Neurostimulation for Canine Epilepsy

Sofie F.M. Bhatti Contributors: Marios Charalambous, Luc Van Ham

Vagus nerve stimulation

Transcranial magnetic stimulation


19 Management of Status Epilepticus and Cluster Seizures in Dogs and Cats

Marios Charalambous Contributor: Sofie F.M. Bhatti

Status epilepticus

Cluster seizures

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