Ketoprofen

Ketoprofen In Dogs & Cats: Uses, Dosage and Side Effects

Overview

• COX-1 inhibition reduces the production of prostaglandins, while lipoxygenase enzyme inhibition potentiates the vascular and cellular phases of inflammation.
• It has antipyretic, analgesic and anti-inflammatory effects.

Uses of Ketoprofen

• Relief of acute pain from musculoskeletal disorders and other painful disorders in the dog and cat.
• Management of chronic pain from osteoarthritis in the dog.

Dose of Ketoprofen in Dogs and Cats

Dogs:

• 2 mg/kg s.c., i.m., i.v. q24h may be repeated for up to 3 consecutive days; 0.25 mg/kg p.o. q24h for up to 30 days, or 1 mg/kg p.o. q24h for up to 5 days.
• Oral dosing for 4 days may follow a single injection of ketoprofen on day one.

Cats:

• 2 mg/kg s.c. q24h may be repeated for up to 3 consecutive days; 1 mg/kg p.o. q24h for up to 5 days.
• Oral dosing for 4 days may follow a single injection of ketoprofen on day one.

Side Effects of Ketoprofen in Dogs and Cats

• GI signs.
• Some animals develop signs with one NSAID and not another.
• A 3–5-day wash-out period should be allowed before starting another NSAID
  after cessation of therapy.
• Stop therapy immediately if GI bleeding is suspected.

Contraindications of Ketoprofen in Dogs and Cats

• Do not give to dehydrated, hypovolaemic or hypotensive patients or those with GI disease or blood clotting problems.
• Do not give to pregnant animals or animals <6 weeks of age.

Some Notes:

• Do not administer concurrently or within 24 hours of other NSAIDs and glucocorticoids.
• Do not administer with other potentially nephrotoxic agents, e.g. aminoglycosides.