Tacrolimus (FK 506)

Tacrolimus (FK 506) In Dogs & Cats: Uses, Dosage and Side Effects

Overview

• T-lymphocyte inhibition.

Uses of Tacrolimus (FK 506)

• Topical aqueous and oil-based formulations have been used in the eyes to treat canine keratoconjunctivitis sicca that is unresponsive to topical ciclosporin.

Dose of Tacrolimus (FK 506) in Dogs and Cats

Dogs:

• Apply 1 drop to the affected eye q12h.

Cats:

• No information is available.

Side Effects of Tacrolimus (FK 506) in Dogs and Cats

• Discomfort on application, including blepharospasm, may occur.
• Topical treatment may be linked to an increased risk of malignancy, such as corneal squamous cell carcinoma.
• The medication may affect circulating levels of insulin, potentially causing hyperglycemia.
• In individuals with diabetes mellitus, the impact of treatment on glycemic control should be monitored.

Contraindications of Tacrolimus (FK 506) in Dogs and Cats

• No information is available.

Some Notes:

• It is suspected to be similar to ciclosporin.