Hydrocortisone Aceponate

Hydrocortisone Aceponate: Uses, Dosage and Side Effects

Overview

• Hydrocortisone aceponate is a pro-drug that is biotransformed to its active form hydrocortisone 17-propionate in the epidermis.

Uses of Hydrocortisone aceponate

• Treatment of inflammatory and pruritic dermatoses.
• management of acute otitis externa and acute exacerbations of recurrent otitis
  externa associated with bacteria and Malassezia.

Dose of Hydrocortisone aceponate in Dogs and Cats

Dogs:

• Cortavance: 2 pumps of spray per 10 cm × 10 cm square of skin for 7 days.
• This delivers 1.52 μg (micrograms) of hydrocortisone aceponate per cm2.
• Easotic: 1 pump (1 ml) per ear q24h for 5 days.

Cats:

• The dose is not established.

Side Effects of Hydrocortisone aceponate in Dogs and Cats

• May result in epidermal atrophy.
• The otic preparation may result in aural erythema and rarely transient hearing loss in geriatric dogs.

Contraindications of Hydrocortisone aceponate in Dogs and Cats

• Do not use on ulcerated skin (Cortavance).
• Do not use if the ear drum is perforated (Easotic).

Some Notes:

• Minimizes systemic side effects (such as increases in liver enzyme activities, depression of cortisol response to ACTH stimulation).
• Microbial infections should be treated appropriately prior to use.
• Patients should be monitored appropriately during long-term use.
• Use with caution in dogs <7 months old as glucocorticoids are known to slow growth.
• The total body surface treated should not exceed a surface corresponding for example to a treatment of two flanks from the spine to the mammary chains including the shoulders and the thighs.