Advances in Parasitology, Volume 117 (PDF)

Advances In Parasitology, Volume 117

By David Rollinson and Russell Stothard

Advances in Parasitology, Volume 118, the latest release in this ongoing series, includes medical studies of parasites of major influence, along with reviews of more traditional areas, such as zoology, taxonomy and life history. New chapters in this release cover topics such as Parasitic and infectious diseases of African wildlife: The Big Five and Improving Translational Power for Antischistosomal Drug Discovery.

Table of Contents

Managing Zoonotic Diseases within and beyond African Wildlife Protected Areas
- Introduction
- The ‘Microscopic Five’
- Challenges of BTb Control at the Wildlife-Livestock Interface: The South African Case Study
- Drivers of Disease: The Kruger National Park Case Study
- Disease Knowledge Gaps and Lessons Learnt from African Protected Areas
- Communities and Conservation
- Conclusions
- Acknowledgements
- References
Improving Translational Power in Antischistosomal Drug Discovery
- Filling the Drug Pipeline for Schistosomiasis
- Evaluating the Importance of S. mansoni Isolate Origin for Early Antischistosomal Drug Discovery
- The S. mansoni Mouse Model for Drug Efficacy Testing
- Infection Intensity of the Patent S. mansoni Mouse Model
- Pharmacokinetic/Pharmacodynamic (PK/PD) Relationship of Selected Drugs
- Concluding Remarks
- Acknowledgements and Funding
- References
Unique Thiol Metabolism in Trypanosomatids: Redox Homeostasis and Drug Resistance
- Introduction
- Trypanothione Metabolism
- Effector Proteins of the Antioxidant Defence: Old and New Actors
- Trypanothione Metabolism Linked to Cysteine, Polyamine, and Pentose Phosphate Pathway
- Role of Redox Active Compounds in Parasite Survival
- Role of Thiol Metabolism in Drug Resistance
- Anti-parasitic Potential of Molecules Targeted Against Redox Metabolism
- Unsolved Questions and Future Prospects
- Acknowledgements
- References

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