Lokivetmab

Lokivetmab In Dogs & Cats: Uses, Dosage and Side Effects

Overview

• Lokivetmab is a caninized monoclonal antibody (mAb) specifically targeting canine interleukin-31.
• The blocking of IL-31 by lokivetmab prevents IL-31 from binding to its co-receptor and
  thereby inhibits IL-31 mediated cell signalling, providing relief from atopic dermatitis-related pruritus and anti-inflammatory activity.

Uses of Lokivetmab

• Indicated for the treatment of clinical manifestations of atopic dermatitis in dogs.
• If the dog does not respond to 2 doses 1 month apart, then alternative treatment should be considered.
• After repeated doses, the clinical efficacy may persist beyond 1 month.

Dose of Lokivetmab in Dogs and Cats

Dogs:

• 1 mg/kg s.c. monthly.

Cats:

• Not indicated.

Side Effects of Lokivetmab in Dogs and Cats

• Hypersensitivity reactions (anaphylaxis, facial oedema, urticaria) may occur in rare cases.

Contraindications of Lokivetmab in Dogs and Cats

• Not for use in dogs <3 kg