Flurbiprofen

Flurbiprofen: Uses, Dosage and Side Effects

Overview

• Inhibits the synthesis of prostaglandin, resulting in anti-inflammatory and analgesic effects.
• Independently of cholinergic mechanisms, prostaglandins also contribute to intraocular surgery-induced miosis by constricting the iris sphincter.

Uses of Flurbiprofen

• Before cataract surgery.
• It is also useful for anterior uveitis and ulcerative keratitis when topical corticosteroids are contraindicated.

Dose of Flurbiprofen in Dogs and Cats

Dogs, Cats:

• 1 drop per eye q6–12h depending on the severity of inflammation.
• 1 drop q30min for 4 doses preoperatively (pre-surgery protocols vary widely).

Side Effects of Flurbiprofen in Dogs and Cats

• local irritation.
• Topical NSAIDs can be used in ulcerative keratitis but with caution as they can delay epithelial healing.

Contraindications of Flurbiprofen in Dogs and Cats

• No information available

Some Notes:

• Topical NSAIDs have the potential to increase intraocular pressure and should be used with caution in dogs and cats with glaucoma.
• Ophthalmic NSAIDs may be used safely with other ophthalmic pharmaceuticals, although concurrent use of drugs which adversely affect the corneal epithelium (e.g. gentamicin) may lead to increased corneal penetration of the NSAID.
• The concurrent use of topical NSAIDs with topical corticosteroids has been identified as a risk factor in humans for precipitating corneal problems.