Clonidine

Clonidine: Uses, Dosage and Side Effects

Overview

Stimulates the secretion of growth hormone-releasing hormone (GHRH) from the hypothalamus.

Uses of Clonidine

• Used for a diagnostic test in patients suspected of pituitary dwarfism (hyposomatotropism) to assess the pituitary’s ability to produce growth hormone (GH).
• Assessment of plasma insulin-like growth factor-1 (IGF-1) concentration in a single
  sample is a useful screening test for growth hormone disorders.
• Used in dogs to control panic-like responses and fear-based behavioral problems.

Dose of Clonidine in Dogs and Cats

Dogs:

• Growth hormone stimulation: 3–10 μg (micrograms)/kg i.v. once.
• Behavioral modification: 0.01–0.05 mg/kg as needed up to q12h (often with food).

Cats:

• No information is available.

Side Effects of Clonidine in Dogs and Cats

• Transient sedation and bradycardia may develop.

Contraindications of Clonidine in Dogs and Cats

• Use very cautiously in animals with renal or cardiovascular disease.

Some Notes:

• The effect develops in about 30 minutes and lasts for 3–4 hours, so often needs to be used tactically (prn).
• Can be used over a longer term but may take 1–2 weeks to see a full response.
• Withdrawal must be done gradually to avoid hypertension.
• Care should be exercised when using with drugs that also lower blood pressure or heart rate.
• Should not be used concurrently with barbiturates, opiates or hypotensive agents, (e.g. beta-blockers)