Aciclovir

Aciclovir: Uses, Dosage and Side Effects

Overview

Aciclovir inhibits viral replication (viral DNA polymerase); depends on viral thymidine kinase for phosphorylation.

Uses of Aciclovir 

• Treatment of feline herpesvirus type 1 (FHV-1) infections of the eyes.
• Although aciclovir’s therapeutic effectiveness is debatable, frequent use (0.5% ointment 5 times a day) may be able to reach corneal concentrations. Since aciclovir is virostatic, it cannot clear a latent viral infection.

Dose of Aciclovir in Dogs and Cats

Dogs:

Not applicable.

Cats:

Apply a small amount to affected eye 5 times daily for a maximum of 3 weeks.

Side Effects of Aciclovir in Dogs and Cats

• Ocular irritation.
• Treatment should not be continued for >3 weeks.

Contraindications of Aciclovir in Dogs and Cats

Systemic aciclovir is toxic in cats.

Some Notes:

Prior to aciclovir, think about ganciclovir and famciclovir. Antiviral drugs may be utilized as part of combination therapy for FHV-1 ulceration that is refractory and severe.