About the Editor xi
Foreword to the Second Edition xiii
Kenneth A. Johnson
Foreword xv
R. Randy Basinger, ACVS Foundation
Preface xvii
Peter Muir
Acknowledgements xix
Peter Muir
Contributing Authors xxi
I Structure and Function 1
Introduction 1
Peter Muir
1 Morphology and Function of the Cruciate Ligaments 3
Hilde de Rooster and Eithne Comerford
2 Biomechanics of the Cruciate Ligaments 13
Susannah J. Sample
3 Cruciate Ligament Remodeling and Repair 21
Connie S. Chamberlain, Erin E. Crowley, and Ray Vanderby Jr.
4 Meniscal Structure and Function 31
Antonio Pozzi and James L. Cook
5 Biomechanics of the Normal and Cranial Cruciate Ligament-Deficient Stifle 39
Antonio Pozzi and Stanley E. Kim
II Etiopathogenesis of Cruciate Ligament Rupture 45
Introduction 45
Peter Muir
6 Histology of Cruciate Ligament Rupture 47
Kei Hayashi
7 Genetics of Cruciate Ligament Rupture 57
Lauren A. Baker and Peter Muir
8 Cruciate Ligament Matrix Metabolism and Development of Laxity 65
Eithne Comerford
9 Morphological Risk Factors for Cruciate Ligament Rupture 73
Eithne Comerford
10 Role of Nitric Oxide Production and Matrix Protease Activity in Cruciate Ligament Degeneration 81
David E. Spreng and Simone Forterre
11 Role of Antibodies to Collagen Type I and II 89
Hilde de Rooster and Eithne Comerford
12 Synovitis Precedes Stifle Instability Associated with Cruciate Ligament Rupture 93
Jason A. Bleedorn
13 Role of Synovial Immune Responses in Stifle Synovitis 101
Peter Muir
III Clinical Features 107
Introduction 107
Peter Muir
14 Epidemiology of Cruciate Ligament Rupture 109
Lauren A. Baker and Peter Muir
15 History and Clinical Signs of Cruciate Ligament Rupture 115
Peter Muir
16 Partial Rupture of the Cranial Cruciate Ligament 119
Peter Muir
17 Caudal Cruciate Ligament Rupture 123
Peter Muir
18 Stress Imaging of the Stifle 127
Stanley E. Kim
19 Stifle Ultrasonography 135
Cristi R. Cook
20 Computed Tomography (CT) of the Stifle 141
Ingrid Gielen and Henri van Bree
21 Magnetic Resonance Imaging of the Stifle 155
Peter V. Scrivani
22 Risk Prediction of Cruciate Ligament Rupture using Stifle Diagnostic Imaging 165
Peter Muir
IV Surgical Treatment 169
Introduction 169
Peter Muir
23 Arthroscopy and Arthrotomy of the Stifle 171
Brian S. Beale, Donald A. Hulse, Antonio Pozzi, and Peter Muir
24 Joint Lavage 185
Peter Muir
25 Extracapsular Stabilization 189
Selena Tinga and Stanley E. Kim
26 Intra-Articular Repair for Cranial Cruciate Ligament Rupture in the Dog 201
Jeffery J. Biskup and Michael G. Conzemius
27 Tibial Plateau Leveling Osteotomy 217
Susan L. Schaefer
28 Tibial Tuberosity Advancement 227
Randy J. Boudrieau
29 Closing Cranial Wedge Ostectomy and Triple Tibial Osteotomy 243
Simon C. Roe
30 Treatment of Excessive Tibial Plateau Angle 253
Michael P. Kowaleski
31 Surgical Management of Cruciate Ligament Rupture Combined with Patella Luxation 261
Anke Langenbach and Denis J. Marcellin-Little
32 Biomechanics of the Cranial Cruciate Ligament-Deficient Stifle Treated by Tibial Osteotomies 271
Antonio Pozzi, Stanley E. Kim, and Selena Tinga
33 Arthroscopic Follow-Up after Surgical Stabilization of the Stifle 279
Brian S. Beale and Donald A. Hulse
34 Cranial Cruciate Ligament Debridement 291
David E. Spreng
35 Surgical Treatment of Concurrent Meniscal Injury 295
Samuel P. Franklin, James L. Cook, and Antonio Pozzi
36 Meniscal Release 301
Antonio Pozzi and James L. Cook
37 Progression of Osteoarthritis after Stifle Stabilization Surgery 307
Susannah J. Sample
38 Clinical Outcomes after Surgical Treatment of Cruciate Ligament Rupture 313
Mary Sarah Bergh and Steven C. Budsberg
39 Success and Failure after Stifle Stabilization Surgery 317
Michael G. Conzemius and Richard B. Evans
40 Diagnosis and Management of Orthopaedic Infection after Stifle Surgery 323
Noel M.M. Moens
V Medical Management of Cruciate Ligament Rupture 331
Introduction 331
Peter Muir
41 Medical Therapy for Stifle Osteoarthritis 333
Steven C. Budsberg
42 Rehabilitation for Dogs with Cruciate Ligament Rupture 343
Denis J. Marcellin-Little and Courtney J. Arnoldy
VI Future Directions 353
Introduction 353
Peter Muir
43 Clinical Research Design and Patient-Oriented Outcomes 355
Dorothy Cimino Brown
44 Total Knee Replacement in the Dog 363
Matthew J. Allen, William D. Liska, and Valentina Brioschi
45 Regenerative Medicine and Cranial Cruciate Ligament Repair 371
Gabriel S. Perrone, Martha M. Murray, and Patrick Vavken
46 Disease-Modifying Medical and Cell-Based Therapy 379
Susannah J. Sample and Peter Muir
Index 385
