Host-Pathogen Interaction: Microbial Metabolism, Pathogenicity and Antiinfectives

Preface vii

Cover Legend ix

List of Contributors xi

Part One Adaptation of Microbial Metabolism in Host/Pathogen Interaction 1

1 Metabolic Adaptation of Human Pathogenic Yersiniae 3
Ann Kathrin Heroven and Petra Dersch*

2 Crosstalk between Metabolism and Virulence of Legionella pneumophila 19
Klaus Heuner and Wolfgang Eisenreich*

3 Metabolism of Intracellular Salmonella enterica 37
Peter Holtkötter and Michael Hensel*

4 The Human Microbiome in Health and Disease 57
Cian Hill, R. Paul Ross, Catherine Stanton, and Paul W. O’Toole*

5 Mechanisms of Dysbiosis in the Inflamed Gut 77
Sebastian E. Winter*

6 Strategies for Nutrient Acquisition by Magnaporthe oryzae during the Infection of Rice 93
Andrew J. Foster, George R. Littlejohn, Darren M. Soanes, and Nicholas J. Talbot*

Part Two New Inhibitors and Targets of Infectious Diseases 109

7 Outer Membrane Proteins as Potential Anti-infective Drug Targets in Mannheimia haemolytica 111
Robert L. Davies*

8 Identification of Anti-infective Compounds Using Amoebae 139
Christopher F. Harrison and Hubert Hilbi*

9 Stress Biology in Fungi and “Omic” Approaches as Suitable Tools for Analyzing Plant–Microbe Interactions 153
Stefan Jacob* and Alexander Yemelin

10 Targeting Plasmids: NewWays to Plasmid Curing 179
Anja Schüffler* and Corinna Kübler

11 Regulation of Secondary Metabolism in the Gray Mold Fungus Botrytis cinerea 201
Muriel Viaud*, Julia Schumacher, Antoine Porquier, and Adeline Simon

Index 217