Enilconazole

Enilconazole: Uses, Dosage and Side Effects

Overview

• Inhibition of cytochrome P450-dependent synthesis of ergosterol in fungal cells, causing increased cell wall permeability and allowing leakage of cellular contents.

Uses of Enilconazole

• Fungal infections of the skin.
• Topical treatment of sinonasal aspergillosis.

Dose of Enilconazole in Dogs and Cats

Dogs:

• Dermatological indications: dilute 1 volume of enilconazole in 50 volumes of water to produce a 2 mg/ml (0.2%) solution (Apply every 3 days for 3–4 applications).
• Nasal aspergillosis: 10 mg/kg instilled once via endoscopically placed sinus catheter or administered q12h into the nasal cavities and sinuses through indwelling tubes for 7–10 days.
• Dilute the solution of enilconazole (100 mg/ml) 50:50 with water.
• The instilled volume should be kept low (<10 ml) to reduce the risk of inhalation and the tubes flushed with an equivalent volume of air.
• Make up a fresh solution as required.

Cats:

• Dermatological indications: doses as for dogs.

Side Effects of Enilconazole in Dogs and Cats

• Hepatotoxic if swallowed.
• Avoid contact with eyes.
• Hypersalivation, GI signs and muscle signs were reported in cats.

Contraindications of Enilconazole in Dogs and Cats

No information is available.

Some Notes:

No information is available.