Desoxycortisone Pivalate

Desoxycortisone pivalate: Uses, Dosage and Side Effects

Overview

• Mineralocorticoid.

Uses of Desoxycortisone pivalate

• Long-acting, replacement therapy for mineralocorticoid deficiency in dogs and cats with primary hypoadrenocorticism.

Dose of Desoxycortisone pivalate in Dogs and Cats

Dogs:

Initial dose 1.5–2.2 mg/kg s.c.

Cats:

Initial dose 2.2 mg/kg. The higher doses seem to be needed.

Side Effects of Desoxycortisone pivalate in Dogs and Cats

• Rarely, pain is seen on injection but repeated injections are not painful in the same animal.
• Overdoses may cause polyuria and hypokalaemia.
• Vomiting, anorexia, polyuria/polydipsia, muzzle swelling, and anaphylaxis have been reported.

Contraindications of Desoxycortisone pivalate in Dogs and Cats

• Non

Some Notes:

• Before treatment, Addison’s disease must be detected.
• Before receiving the veterinary medicinal product, dogs with severe hypovolaemia, dehydration, pre-renal azotemia, and poor tissue perfusion (known as “Addisonian crisis”) must be rehydrated with intravenous saline.
• In dogs with congestive heart disease, severe renal illness, primary hepatic failure, or edema, lower doses.
• Many dogs need fewer doses after receiving the authorized 2.2 mg/kg.
• This is why many veterinarians start at 1.5 mg/kg s.c., especially in bigger dogs.
• The final dose can be 1.0–2.7 mg/kg after further dose reduction or rise.