Amprolium

Amprolium: Uses, Dosage and Side Effects

Overview

Amprolium is a thiamine analogue that disrupts protozoal metabolism.

Uses of Amprolium

• Treatment of coccidiosis in dogs and cats.

N.B : Limit duration of therapy to 2 weeks.

Dose of Amprolium in Dogs and Cats

Dogs:

For coccidiosis various doses are suggested:

• 200–300 mg/ dog p.o. q24h for 7–12 days.
• Small puppies reduce to 60-100 mg/ dog p.o. q24h.
• larger puppies use 200 mg/dog p.o. q24h.

Cats:

60–100 mg/cat p.o. q24h for 7 days or 110–220 mg/kg on food q24h for 7–12 days.

Side Effects of Amprolium in Dogs and Cats

• Anorexia, diarrhoea and depression in dogs.
• Prolonged high doses can cause thiamine deficiency and may result in neurological signs.

Contraindications of Amprolium in Dogs and Cats

• Do not use for more than 2 weeks to minimize risk of thiamine deficiency in the host animal.

Some Notes:

• Exogenously administered thiamine may reduce efficacy.