Miconazole

Miconazole In Dogs & Cats: Uses, Dosage and Side Effects

Overview

• Inhibits cytochrome P450-dependent synthesis of ergosterol in fungal cells causing increased cell wall permeability and allowing leakage of cellular contents.
• Miconazole has activity against Malassezia, Cryptococcus, Candida and Coccidioides.

Uses of Miconazole

• Treatment of fungal skin and ear infections, including dermatophytosis.
• Miconazole shampoo is useful in the treatment of dermatophytosis in cats but concurrent itraconazole administration is required.

Dose of Miconazole in Dogs and Cats

Dogs:

• Fungal otitis: 2–12 drops in affected ear q12–24h (Surolan). 1 ml per ear q24h for 5 days (Easotic). 5 drops in affected ear q12h (Aurimic).
• Dermatophytosis: Apply a thin layer of cream topically to the affected area twice daily. Continue for 2 weeks after a clinical cure and negative fungal cultures.
• Malassezia dermatitis: Shampoo twice weekly until the clinical signs subside and weekly thereafter or as necessary to keep the condition under control (Malaseb, Adaxio).
• Small localized skin infections: apply a few drops to affected skin q12h (Aurimic).

Cats:

• Fungal otitis: doses as for dogs.
• Dermatophytosis: topical; doses as for dogs.
• Microsporum canis: shampoo twice weekly while administering itraconazole for 6–10 weeks or until coat brushings are negative for the culture of M. canis, whichever is the longer (Malaseb). The maximum length of the treatment period should not
  exceed 16 weeks.
• Small localized skin infections: doses as for dogs.

Side Effects of Miconazole in Dogs and Cats

• No information is available.

Contraindications of Miconazole in Dogs and Cats

• No information is available.