{"id":87,"date":"2023-01-17T19:18:10","date_gmt":"2023-01-17T17:18:10","guid":{"rendered":"https:\/\/www.vetdrugslist.com\/?p=87"},"modified":"2025-05-16T23:11:15","modified_gmt":"2025-05-16T20:11:15","slug":"acyclovir-dose","status":"publish","type":"post","link":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/acyclovir-dose\/","title":{"rendered":"Acyclovir"},"content":{"rendered":"<p style=\"text-align: center; font-size: 21px; font-family: sans-serif;\"><strong>Acyclovir: Uses, Dosage and Side Effects In Dogs, Cats, Horses and Birds<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-97 aligncenter\" src=\"https:\/\/www.vet-ebooks.com\/wp-content\/uploads\/2024\/10\/Acyclovir.jpg\" alt=\"Aciclovir: Uses, Dosage and Side Effects in Dogs, Cats, Horses and All Animals\" width=\"570\" height=\"342\" \/><\/p>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Overview<\/strong><\/h2>\n<p>Acyclovir inhibits viral replication (viral DNA polymerase); depends on viral thymidine kinase for phosphorylation.<\/p>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Uses of Acyclovir in Dogs, Cats, Horses and Birds<\/strong><\/h2>\n<ul>\n<li><strong>Feline Herpesvirus Type 1 (FHV-1)<\/strong>: Primarily used as an ophthalmic ointment to treat infections of the eyes caused by FHV-1.<\/li>\n<li><strong>Canine Herpesvirus (CHV)<\/strong>: Occasionally used as adjunctive treatment for neonatal herpes infections.<\/li>\n<li><strong>Equine Herpesvirus<\/strong>: Investigated as a treatment for equine herpesvirus infections, though oral bioavailability is limited.<\/li>\n<li><strong>Birds (Psittacine species)<\/strong>: Utilized for treating psittacid alphaherpesvirus-1 (formerly Pacheco&#8217;s disease) when administered early.<\/li>\n<\/ul>\n<div class='code-block code-block-20' style='margin: 8px auto; text-align: center; display: block; clear: both;'>\n<a href=\"https:\/\/www.vet-ebooks.com\/premium-memberships\/\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17003\" src=\"https:\/\/www.vet-ebooks.com\/wp-content\/uploads\/2024\/10\/veterinary-books-1.jpg\" width=\"480\" height=\"98\"  alt=\"Vet Books\"\/><\/a><\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Dose of Acyclovir in Dogs, Cats, Horses and Birds<\/strong><\/h2>\n<table style=\"width: 100%; border-collapse: collapse; margin: 10px 0; background-color: #f2f2f2;\">\n<thead>\n<tr style=\"background-color: #fabd14; color: #fff; font-family: sans-serif;\">\n<th style=\"padding: 8px;\">Species<\/th>\n<th style=\"padding: 8px;\">Condition<\/th>\n<th style=\"padding: 8px;\">Dosage<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 8px;\"><strong>Dogs<\/strong><\/td>\n<td style=\"padding: 8px;\">Canine Herpesvirus<\/td>\n<td style=\"padding: 8px;\">10 mg\/kg orally every 6 hours for 5 days (extra-label use).<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px;\"><strong>Cats<\/strong><\/td>\n<td style=\"padding: 8px;\">Feline Herpesvirus (ophthalmic)<\/td>\n<td style=\"padding: 8px;\">Apply ointment 5 times daily for up to 3 weeks.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px;\"><strong>Horses<\/strong><\/td>\n<td style=\"padding: 8px;\">Neonatal Equine Herpesvirus<\/td>\n<td style=\"padding: 8px;\">10 mg\/kg IV every 12 hours for neonatal foals.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px;\"><strong>Birds<\/strong><\/td>\n<td style=\"padding: 8px;\">Psittacid Alphaherpesvirus-1<\/td>\n<td style=\"padding: 8px;\">80 mg\/kg orally every 8 hours for 7 days.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div class='code-block code-block-30' style='margin: 8px 0; clear: both;'>\n <html>\n  <head>\n    <style>\n    \n \n      #calculator {\n        width: 100%;\n        margin: auto;\n      }\n      \n      @media (max-width: 600px) {\n        #calculator {\n          width: 90%;\n        }\n      }\n      \n      #calculator23 {\n        display: block;\n        margin-bottom: 8px;\n        font-size: 14px;\nfont-family: sans-serif;font-weight:600;\n      }\n      \n      #calculator24{\n        width: 100%;\n        padding: 12px 20px;\n        margin: 8px 0;\n        box-sizing: border-box;\n        border: 2px solid #ccc;\n        border-radius: 4px;\n      }\n      \n      #calculator25 {\n        width: 100%;\n    background-color: #fabd14;\n    color: white;\n    padding: 11px 18px;\n    margin: 5px 0;\n    border: none;\n    border-radius: 4px;\n    cursor: pointer;\n    font-size: 15px;\n    font-family: sans-serif;\n    font-weight: 600;\n}\n      }\n      \n      #result {\n        font-size: 18px;\n        font-weight: bold;\n      }\n    <\/style>\n  <\/head>\n  <body>\n  \n \n\n  <h2 style=\"border-bottom: 2px #fabd14 solid;font-size: 20px;\" id=\"cd-understanding\" class=\"cd-section-title\"><span><strong>Drug Dosage Calculator<\/strong><\/span><\/h2>\n    <form id=\"calculator\">\n      <label id=\"calculator23\" for=\"weight\">Animal Weight (kg):<\/label>\n      <input type=\"text\" id=\"weight\" name=\"weight\" id=\"calculator24\">\n      <label for=\"dose\" id=\"calculator23\">Drug Dose (mg\/kg):<\/label>\n      <input type=\"text\" id=\"dose\" name=\"dose\" id=\"calculator24\">\n      <label for=\"concentration\" id=\"calculator23\">Drug Concentration (mg\/mL or mg\/tablet):<\/label>\n      <input type=\"text\" id=\"concentration\" name=\"concentration\" id=\"calculator24\">\n      <button type=\"button\" onclick=\"calculate()\" id=\"calculator25\">Calculate<\/button>\n    <\/form> \n    \n    <p style=\"\n    font-size: 13px;\n    font-weight: 600;\n    font-family: sans-serif;\n    background: #444;\n    padding: 5px;\n    border-radius: 5px;\n    color: #fff;\n\">You Should Give: <span id=\"result\"><\/span><\/p>\n\n\n    \n    <script>\n      function calculateDose(weight, dose, concentration) {\n        return (weight * dose \/ concentration).toFixed(2);\n      }\n      \n      function calculate() {\n        let weight = document.getElementById(\"weight\").value;\n        let dose = document.getElementById(\"dose\").value;\n        let concentration = document.getElementById(\"concentration\").value;\n        let result = calculateDose(weight, dose, concentration);\n        document.getElementById(\"result\").innerHTML = result + \" mL or tablet \";\n      }\n    <\/script>\n  <\/body>\n<\/html>\n<\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Side Effects of Acyclovir in Dogs, Cats, Horses and Birds<\/strong><\/h2>\n<ul>\n<li><strong>Cats<\/strong>: Ocular irritation from topical use; systemic use is not recommended due to risks of <strong>myelosuppression, renal tubular necrosis, and hepatic necrosis<\/strong>.<\/li>\n<li><strong>Dogs<\/strong>: GI signs such as vomiting and diarrhea, and renal toxicity at high doses.<\/li>\n<li><strong>Birds<\/strong>: Tissue necrosis at injection sites; nephrotoxicity possible with rapid IV administration.<\/li>\n<li><strong>Horses<\/strong>: Tremors, sweating, and colic when given IV over a short period.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Contraindications of Acyclovir in Dogs, Cats, Horses and Birds<\/strong><\/h2>\n<ul>\n<li><strong>Cats<\/strong>: Systemic use is contraindicated due to severe toxicity risks.<\/li>\n<li><strong>Dogs and Horses<\/strong>: Use cautiously in animals with <strong>renal impairment<\/strong> or dehydration.<\/li>\n<li><strong>Birds<\/strong>: Avoid rapid IV administration due to risk of necrosis.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Some Notes:<\/strong><\/h2>\n<ul>\n<li><strong>Alternative Treatments<\/strong>: Famciclovir and ganciclovir are preferred for feline herpes infections due to better safety profiles.<\/li>\n<li><strong>Drug Interactions<\/strong>:\n<ul>\n<li><strong>Nephrotoxic Drugs<\/strong> (e.g., aminoglycosides, amphotericin B) can increase the risk of nephrotoxicity.<\/li>\n<li><strong>Probenecid<\/strong>: Increases acyclovir exposure by inhibiting renal clearance.<\/li>\n<li><strong>Theophylline<\/strong>: May raise theophylline concentrations; monitor when using concurrently.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Monitoring<\/strong>: Regular renal function tests (BUN, serum creatinine) are recommended with prolonged use or IV administration.<\/li>\n<li><strong>Overdose Management<\/strong>: GI decontamination is recommended for overdoses \u2265150 mg\/kg. Acyclovir is removed by hemodialysis, but not by peritoneal dialysis.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Acyclovir: Uses, Dosage and Side Effects In Dogs, Cats, Horses and Birds Overview Acyclovir inhibits viral replication (viral DNA polymerase); depends on viral thymidine kinase for phosphorylation. Uses of Acyclovir in Dogs, Cats, Horses and Birds Feline Herpesvirus Type 1 (FHV-1): Primarily used as an ophthalmic ointment to treat infections of the eyes caused by [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":990,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[3],"class_list":["post-87","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-antimicrobials","tag-aa"],"_links":{"self":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/87","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/comments?post=87"}],"version-history":[{"count":0,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/87\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media\/990"}],"wp:attachment":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media?parent=87"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/categories?post=87"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/tags?post=87"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}