{"id":823,"date":"2023-04-14T04:40:54","date_gmt":"2023-04-14T02:40:54","guid":{"rendered":"https:\/\/www.vetdrugslist.com\/?p=823"},"modified":"2025-12-30T20:55:53","modified_gmt":"2025-12-30T18:55:53","slug":"diazepam","status":"publish","type":"post","link":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/diazepam\/","title":{"rendered":"Diazepam"},"content":{"rendered":"<p style=\"text-align: center; font-size: 24px; font-family: sans-serif;\"><strong>Diazepam: Uses, Dosage and Side Effects<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-855 aligncenter\" src=\"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/04\/Diazepam.jpg\" alt=\"Diazepam: Uses, Dosage and Side Effects\" width=\"634\" height=\"381\" \/><\/p>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Overview<\/strong><\/h2>\n<p>Enhances the activity of the major inhibitory central nervous system neurotransmitter, gamma-aminobutyric acid (GABA), through binding to the benzodiazepine site of the GABAA receptor.<\/p>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Uses of Diazepam<\/strong><\/h2>\n<ul>\n<li><strong> Anticonvulsant:<\/strong> diazepam is the drug of choice for the short-term emergency control of severe epileptic seizures and status epilepticus in dogs and cats.<\/li>\n<li><strong>Anxiolytic:<\/strong> used in behavioral medicine for anxiety and fear-related disorders in dogs and cats, especially where there are signs of panic.<\/li>\n<li><strong>Skeletal muscle relaxant<\/strong> (e.g. urethral muscle spasm and tetanus).<\/li>\n<li>Used in cats as an <strong>appetite stimulant.<\/strong><\/li>\n<\/ul>\n<div class='code-block code-block-12' style='margin: 8px auto; text-align: center; display: block; clear: both;'>\n<a target=\"_blank\" href=\"https:\/\/www.vet-ebooks.com\/premium-memberships\/\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-17003\" src=\"https:\/\/www.vet-ebooks.com\/wp-content\/uploads\/2024\/10\/veterinary-books-1.jpg\" width=\"480\" height=\"98\"  alt=\"Vet Books\"\/><\/a><\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Dose of Diazepam in Dogs and Cats<\/strong><\/h2>\n<p><strong>Dogs:<\/strong><\/p>\n<ul>\n<li><strong>Anxiolytic:<\/strong> 0.5\u20132.0 mg\/kg p.o as required.<\/li>\n<li><strong>Sedation and premedication:<\/strong> 0.2\u20130.5 mg\/kg i.v., i.m.<\/li>\n<li><strong>Skeletal muscle relaxation:<\/strong> 2\u201310 mg\/dog p.o. q8\u201312h.<\/li>\n<li><strong>Emergency management of seizures, including status epilepticus<\/strong>: bolus dose of 0.5\u20131 mg\/kg i.v. or intrarectally. Time to onset of clinical effect is 2\u20133 min for i.v. use; therefore, repeat every 10 min if no clinical effect, up to 3 times. Additional doses may be administered if appropriate supportive care facilities are available (for support of respiration).<\/li>\n<li><strong>Constant rate i.v. infusion for control of status epilepticus or cluster seizures<\/strong>:<br \/>\ninitial rate 0.5\u20132 mg\/kg\/h, titrated to effect.<\/li>\n<\/ul>\n<p><strong>Cats:<\/strong><\/p>\n<ul>\n<li><strong>Anxiolytic:<\/strong> 0.2\u20130.4 mg\/kg p.o. q8h.<\/li>\n<li><strong>Appetite stimulant:<\/strong> 0.1\u20130.2 mg\/kg i.v. once.<\/li>\n<li><strong>Behavioral modification of urine spraying and muscle relaxation<\/strong>: 1.25\u20135 mg\/cat p.o. q8h.<\/li>\n<li>The dose should be gradually increased to achieve the desired effect without<br \/>\nconcurrent sedation.<\/li>\n<li><strong>Emergency management of seizures including status epilepticus<\/strong>:<\/li>\n<li>A bolus dose of 0.5\u20131 mg\/kg i.v. or intrarectally if venous access is not available.<\/li>\n<li>Time to onset of clinical effect is 2\u20133 min for i.v. use, therefore, repeat every 10 min if there is no clinical effect, up to a maximum of 3 times.<\/li>\n<li><strong>Constant rate i.v. infusion for the control of status epilepticus or cluster seizures:<\/strong> initial rate of 0.5 mg\/ kg\/h.<\/li>\n<li>Care should be taken in cats to avoid overdosing; if cats demonstrate excessive sedation then diazepam should be discontinued.<\/li>\n<li>Consider monitoring liver parameters.<\/li>\n<\/ul>\n<div class='code-block code-block-2' style='margin: 8px auto 8px 0; text-align: left; display: block; clear: both;'>\n <html>\n  <head>\n    <style>\n    \n \n      #calculator {\n        width: 100%;\n        margin: auto;\n      }\n      \n      @media (max-width: 600px) {\n        #calculator {\n          width: 90%;\n        }\n      }\n      \n      #calculator23 {\n        display: block;\n        margin-bottom: 8px;\n        font-size: 14px;\nfont-family: sans-serif;font-weight:600;\n      }\n      \n      #calculator24{\n        width: 100%;\n        padding: 12px 20px;\n        margin: 8px 0;\n        box-sizing: border-box;\n        border: 2px solid #ccc;\n        border-radius: 4px;\n      }\n      \n      #calculator25 {\n        width: 100%;\n    background-color: #fabd14;\n    color: white;\n    padding: 11px 18px;\n    margin: 5px 0;\n    border: none;\n    border-radius: 4px;\n    cursor: pointer;\n    font-size: 15px;\n    font-family: sans-serif;\n    font-weight: 600;\n}\n      }\n      \n      #result {\n        font-size: 18px;\n        font-weight: bold;\n      }\n    <\/style>\n  <\/head>\n  <body>\n  \n \n\n  <h2 style=\"border-bottom: 2px #fff7e6 solid;\" class=\"cd-section-title\"><span><strong>Drug Dosage Calculator<\/strong><\/span><\/h2>\n    <form id=\"calculator\">\n      <label id=\"calculator23\" for=\"weight\">Animal Weight (kg):<\/label>\n      <input type=\"text\" id=\"weight\" name=\"weight\" id=\"calculator24\">\n      <label for=\"dose\" id=\"calculator23\">Drug Dose (mg\/kg):<\/label>\n      <input type=\"text\" id=\"dose\" name=\"dose\" id=\"calculator24\">\n      <label for=\"concentration\" id=\"calculator23\">Drug Concentration (mg\/mL or mg\/tablet):<\/label>\n      <input type=\"text\" id=\"concentration\" name=\"concentration\" id=\"calculator24\">\n      <button type=\"button\" onclick=\"calculate()\" id=\"calculator25\">Calculate<\/button>\n    <\/form> \n    \n    <p style=\"\n    font-size: 13px;\n    font-weight: 600;\n    font-family: sans-serif;\n    background: #444;\n    padding: 5px;\n    border-radius: 5px;\n    color: #fff;\n\">You Should Give: <span id=\"result\"><\/span><\/p>\n\n\n    \n    <script>\n      function calculateDose(weight, dose, concentration) {\n        return (weight * dose \/ concentration).toFixed(2);\n      }\n      \n      function calculate() {\n        let weight = document.getElementById(\"weight\").value;\n        let dose = document.getElementById(\"dose\").value;\n        let concentration = document.getElementById(\"concentration\").value;\n        let result = calculateDose(weight, dose, concentration);\n        document.getElementById(\"result\").innerHTML = result + \" mL or tablet \";\n      }\n    <\/script>\n  <\/body>\n<\/html>\n<\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Side Effects of Diazepam in Dogs and Cats<\/strong><\/h2>\n<ul>\n<li>Ataxia, sedation, and lethargy are common.<\/li>\n<li>Slow i.v. injections (at least 1 min per 5 mg) can prevent paradoxical excitation (including hostility) and pain in normal dogs.<\/li>\n<li>Intramuscular injection hurts and disrupts drug uptake.<\/li>\n<li>If i.v. access is unavailable, rectal administration can manage seizures, but it takes 5\u201310 min to start.<\/li>\n<li>In older animals, those with liver dysfunction, and those getting beta-1 antagonists, repeated doses in rapid succession may prolong the duration of action.<\/li>\n<li>Repeated oral giving causes feline fulminant hepatic necrosis.<\/li>\n<li>Emulsion diazepam is favored for intravenous injection because propylene glycol can cause thrombophlebitis.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Contraindications of Diazepam in Dogs and Cats<\/strong><\/h2>\n<ul>\n<li>Patients with CNS depression, respiratory depression, severe muscle<br \/>\nweakness, or hepatic impairment (as may worsen hepatic encephalopathy).<\/li>\n<li>long-term treatment of canine and feline behavioral disorders due to the risks of disinhibition and interference with memory and learning.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Some Notes:<\/strong><\/h2>\n<ul>\n<li>Do not dilute or mix with other agents.<\/li>\n<li>Due to extensive metabolism by the hepatic microsomal enzyme system,<br \/>\ninteractions with other drugs metabolized in this way are common.<\/li>\n<li>Cimetidine and omeprazole inhibit the metabolism of diazepam and may prolong clearance.<\/li>\n<li>Concurrent use of phenobarbital may lead to a decrease in the half-life of diazepam.<\/li>\n<li>An enhanced sedative effect may be seen if antihistamines or opioid analgesics are<br \/>\nadministered with diazepam, and diazepam will reduce the dose requirement of other anesthetic agents.<\/li>\n<li>When given with diazepam the effects of digoxin may be increased.<\/li>\n<li>Diazepam may be used in combination with tricyclic antidepressant therapy for the<br \/>\nmanagement of more severe behavioral responses<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Diazepam: Uses, Dosage and Side Effects Overview Enhances the activity of the major inhibitory central nervous system neurotransmitter, gamma-aminobutyric acid (GABA), through binding to the benzodiazepine site of the GABAA receptor. Uses of Diazepam Anticonvulsant: diazepam is the drug of choice for the short-term emergency control of severe epileptic seizures and status epilepticus in dogs [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1315,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[73,35],"tags":[20],"class_list":["post-823","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-anticonvulsants","category-cns","tag-benzodiazepine"],"_links":{"self":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/823","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/comments?post=823"}],"version-history":[{"count":0,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/823\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media\/1315"}],"wp:attachment":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media?parent=823"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/categories?post=823"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/tags?post=823"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}