{"id":820,"date":"2023-05-01T02:04:37","date_gmt":"2023-05-01T02:04:37","guid":{"rendered":"https:\/\/www.vetdrugslist.com\/?p=820"},"modified":"2023-05-01T02:04:55","modified_gmt":"2023-05-01T02:04:55","slug":"dexrazoxane","status":"publish","type":"post","link":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/dexrazoxane\/","title":{"rendered":"Dexrazoxane"},"content":{"rendered":"<p style=\"text-align: center; font-size: 24px; font-family: sans-serif;\"><strong>Dexrazoxane: Uses, Dosage and Side Effects<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-1421\" src=\"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/05\/Dexrazoxane.jpg\" alt=\"Dexrazoxane: Uses, Dosage and Side Effects\" width=\"674\" height=\"405\" srcset=\"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/05\/Dexrazoxane.jpg 800w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/05\/Dexrazoxane-300x180.jpg 300w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/05\/Dexrazoxane-768x461.jpg 768w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/05\/Dexrazoxane-696x418.jpg 696w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/05\/Dexrazoxane-700x420.jpg 700w\" sizes=\"auto, (max-width: 674px) 100vw, 674px\" \/><\/p>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Overview<\/strong><\/h2>\n<ul>\n<li>Prevents the formation of anthracycline-iron complex free radicals thought to be the cause of anthracycline-induced cardiotoxicity and extravasation reactions.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Uses of Dexrazoxane<\/strong><\/h2>\n<ul>\n<li>Manage complications associated with the use of anthracycline chemotherapeutics.<\/li>\n<\/ul>\n<div class='code-block code-block-12' style='margin: 8px auto; text-align: center; display: block; clear: both;'>\n<a target=\"_blank\" href=\"https:\/\/www.vet-ebooks.com\/premium-memberships\/\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-17003\" src=\"https:\/\/www.vet-ebooks.com\/wp-content\/uploads\/2024\/10\/veterinary-books-1.jpg\" width=\"480\" height=\"98\"  alt=\"Vet Books\"\/><\/a><\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Dose of Dexrazoxane in Dogs and Cats<\/strong><\/h2>\n<p><strong>Dogs:<\/strong><\/p>\n<ul>\n<li><em><strong>Extravasation injury:<\/strong><\/em><\/li>\n<li>Terminate doxorubicin infusion and administer 1000 mg\/m2 i.v. into a separate infusion (ideally within 6 hours).<\/li>\n<li>Repeat on day 2 (1000 mg\/m2 i.v.) and day 3 (500 mg\/ m2 i.v.).<\/li>\n<li>Lower doses have also been shown to be effective (250\u2013500 mg\/m2 i.v.).<\/li>\n<li><em><strong>Prevention of doxorubicin cardiotoxicity:<\/strong> <\/em><\/li>\n<li>10 minutes before doxorubicin 10 times the administered milligram dose of doxorubicin i.v. over 5\u201310 minutes.<\/li>\n<\/ul>\n<p><strong>Cats:<\/strong><\/p>\n<p>Unknown.<\/p>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Side Effects of Dexrazoxane in Dogs and Cats<\/strong><\/h2>\n<ul>\n<li>Myelosuppression is documented in humans.<\/li>\n<li>It may also decrease the clinical efficacy of anthracycline anti-neoplastic agents.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Contraindications of Dexrazoxane in Dogs and Cats<\/strong><\/h2>\n<p>unknown<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dexrazoxane: Uses, Dosage and Side Effects Overview Prevents the formation of anthracycline-iron complex free radicals thought to be the cause of anthracycline-induced cardiotoxicity and extravasation reactions. Uses of Dexrazoxane Manage complications associated with the use of anthracycline chemotherapeutics. Dose of Dexrazoxane in Dogs and Cats Dogs: Extravasation injury: Terminate doxorubicin infusion and administer 1000 mg\/m2 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1421,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-820","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-antidotes"],"_links":{"self":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/820","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/comments?post=820"}],"version-history":[{"count":0,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/820\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media\/1421"}],"wp:attachment":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media?parent=820"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/categories?post=820"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/tags?post=820"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}