{"id":643,"date":"2023-02-24T15:29:03","date_gmt":"2023-02-24T13:29:03","guid":{"rendered":"https:\/\/www.vetdrugslist.com\/?p=643"},"modified":"2023-04-29T14:53:26","modified_gmt":"2023-04-29T14:53:26","slug":"clopidogrel","status":"publish","type":"post","link":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/clopidogrel\/","title":{"rendered":"Clopidogrel"},"content":{"rendered":"<p style=\"text-align: center; font-size: 24px; font-family: sans-serif;\"><strong>Clopidogrel: Uses, Dosage and Side Effects<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-669 aligncenter\" src=\"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/02\/Clopidogrel.jpg\" alt=\"Clopidogrel: Uses, Dosage and Side Effects\" width=\"588\" height=\"353\" \/><\/p>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Overview<\/strong><\/h2>\n<p>Clopidogrel irreversibly binds to the ADP(2Y12) receptor on platelets, <strong>preventing both primary and secondary platelet aggregation<\/strong> in response to stimuli.<\/p>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Uses of Clopidogrel<\/strong><\/h2>\n<ul>\n<li><strong>Thromboprophylaxis<\/strong> in cats and dogs.<\/li>\n<li>Commonly used to <strong>reduce the risk of thrombus formation<\/strong> in cats with advanced cardiac disease, to reduce the risk of thromboembolism in cats with a pre-existing thrombus, or recurrence of embolism in cats with a previous arterial thromboembolic event.<\/li>\n<\/ul>\n<div class='code-block code-block-12' style='margin: 8px auto; text-align: center; display: block; clear: both;'>\n<a target=\"_blank\" href=\"https:\/\/www.vet-ebooks.com\/premium-memberships\/\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-17003\" src=\"https:\/\/www.vet-ebooks.com\/wp-content\/uploads\/2024\/10\/veterinary-books-1.jpg\" width=\"480\" height=\"98\"  alt=\"Vet Books\"\/><\/a><\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Dose of Clopidogrel in Dogs and Cats<\/strong><\/h2>\n<p><strong>Dogs:<\/strong><\/p>\n<ul>\n<li>1.1\u20134 mg\/kg p.o. q24h.<\/li>\n<li>A single loading dose of 4\u201310 mg\/kg p.o. may help achieve therapeutic concentrations more rapidly.<\/li>\n<\/ul>\n<p><strong>Cats:<\/strong><\/p>\n<ul>\n<li>18.75 mg\/cat p.o. q24h.<\/li>\n<li>A single loading dose of 4\u201310 mg\/kg p.o. may help achieve therapeutic concentrations more rapidly<\/li>\n<\/ul>\n<div class='code-block code-block-2' style='margin: 8px auto 8px 0; text-align: left; display: block; clear: both;'>\n <html>\n  <head>\n    <style>\n    \n \n      #calculator {\n        width: 100%;\n        margin: auto;\n      }\n      \n      @media (max-width: 600px) {\n        #calculator {\n          width: 90%;\n        }\n      }\n      \n      #calculator23 {\n        display: block;\n        margin-bottom: 8px;\n        font-size: 14px;\nfont-family: sans-serif;font-weight:600;\n      }\n      \n      #calculator24{\n        width: 100%;\n        padding: 12px 20px;\n        margin: 8px 0;\n        box-sizing: border-box;\n        border: 2px solid #ccc;\n        border-radius: 4px;\n      }\n      \n      #calculator25 {\n        width: 100%;\n    background-color: #fabd14;\n    color: white;\n    padding: 11px 18px;\n    margin: 5px 0;\n    border: none;\n    border-radius: 4px;\n    cursor: pointer;\n    font-size: 15px;\n    font-family: sans-serif;\n    font-weight: 600;\n}\n      }\n      \n      #result {\n        font-size: 18px;\n        font-weight: bold;\n      }\n    <\/style>\n  <\/head>\n  <body>\n  \n \n\n  <h2 style=\"border-bottom: 2px #fff7e6 solid;\" class=\"cd-section-title\"><span><strong>Drug Dosage Calculator<\/strong><\/span><\/h2>\n    <form id=\"calculator\">\n      <label id=\"calculator23\" for=\"weight\">Animal Weight (kg):<\/label>\n      <input type=\"text\" id=\"weight\" name=\"weight\" id=\"calculator24\">\n      <label for=\"dose\" id=\"calculator23\">Drug Dose (mg\/kg):<\/label>\n      <input type=\"text\" id=\"dose\" name=\"dose\" id=\"calculator24\">\n      <label for=\"concentration\" id=\"calculator23\">Drug Concentration (mg\/mL or mg\/tablet):<\/label>\n      <input type=\"text\" id=\"concentration\" name=\"concentration\" id=\"calculator24\">\n      <button type=\"button\" onclick=\"calculate()\" id=\"calculator25\">Calculate<\/button>\n    <\/form> \n    \n    <p style=\"\n    font-size: 13px;\n    font-weight: 600;\n    font-family: sans-serif;\n    background: #444;\n    padding: 5px;\n    border-radius: 5px;\n    color: #fff;\n\">You Should Give: <span id=\"result\"><\/span><\/p>\n\n\n    \n    <script>\n      function calculateDose(weight, dose, concentration) {\n        return (weight * dose \/ concentration).toFixed(2);\n      }\n      \n      function calculate() {\n        let weight = document.getElementById(\"weight\").value;\n        let dose = document.getElementById(\"dose\").value;\n        let concentration = document.getElementById(\"concentration\").value;\n        let result = calculateDose(weight, dose, concentration);\n        document.getElementById(\"result\").innerHTML = result + \" mL or tablet \";\n      }\n    <\/script>\n  <\/body>\n<\/html>\n<\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Side Effects of Clopidogrel in Dogs and Cats<\/strong><\/h2>\n<ul>\n<li>Use with care in patients with renal or hepatic impairment.<\/li>\n<li>Tablet formulations for humans are film-coated, which needs to be broken for appropriate dosing in cats.<\/li>\n<li>Many cats dislike the taste of the tablets when the film-coating is broken so it is recommended that the tablet be administered in a gelatin capsule to improve patient compliance.<\/li>\n<li>The taste of newer resized formulations is anecdotally still not tolerated.<\/li>\n<li>Overdoses will be expected to lead to bleeding disorders<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Contraindications of Clopidogrel in Dogs and Cats<\/strong><\/h2>\n<ul>\n<li>Bleeding disorders.<\/li>\n<li>GI ulceration.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Some Notes:<\/strong><\/h2>\n<ul>\n<li>May be substituted for <strong>aspirin<\/strong> if aspirin is not tolerated.<\/li>\n<li>May be used in <strong>conjunction with aspirin<\/strong> (as the drugs act on different parts of the platelet activation cycle).<\/li>\n<li>Recent evidence (FATCAT study) suggests clopidogrel is <strong>superior compared with aspirin<\/strong> in the delay of feline recurrent thromboembolic events secondary to cardiac disease.<\/li>\n<li>High risk of bleeding complications if used with anticoagulants.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Clopidogrel: Uses, Dosage and Side Effects Overview Clopidogrel irreversibly binds to the ADP(2Y12) receptor on platelets, preventing both primary and secondary platelet aggregation in response to stimuli. Uses of Clopidogrel Thromboprophylaxis in cats and dogs. Commonly used to reduce the risk of thrombus formation in cats with advanced cardiac disease, to reduce the risk of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1174,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[75],"class_list":["post-643","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-anticoagulants","tag-platelet-aggregation-inhibitor"],"_links":{"self":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/643","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/comments?post=643"}],"version-history":[{"count":0,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/643\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media\/1174"}],"wp:attachment":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media?parent=643"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/categories?post=643"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/tags?post=643"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}