{"id":622,"date":"2023-02-24T15:53:41","date_gmt":"2023-02-24T13:53:41","guid":{"rendered":"https:\/\/www.vetdrugslist.com\/?p=622"},"modified":"2023-09-04T13:14:18","modified_gmt":"2023-09-04T10:14:18","slug":"clarithromycin","status":"publish","type":"post","link":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/clarithromycin\/","title":{"rendered":"Clarithromycin"},"content":{"rendered":"

Clarithromycin (Biaxin): Uses, Dosage and Side Effects<\/strong><\/p>\n

$\"Clarithromycin:$ <\/p>\n\n

Overview<\/strong><\/h2>\n
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Time-dependent macrolide antibacterial<\/strong> that binds to the 50S ribosome, inhibiting peptide bonds and therefore protein formation.<\/li>\n
Derived from erythromycin and with greater activity.<\/li>\n<\/ul>\n
Uses of Clarithromycin<\/strong><\/h2>\n
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Useful in the management of respiratory tract infections, mild to moderate skin and soft tissue infections, and non-tubercular mycobacterial infections.<\/li>\n
Active against Gram-positive cocci (some Staphylococcus spp. resistant),
\nGram-positive bacilli, some Gram-negative bacilli (e.g. Pasteurella) and some spirochaetes (e.g. Helicobacter).<\/li>\n
Some strains of Actinomyces, Nocardia, Chlamydia, and Rickettsia are also inhibited.<\/li>\n
Most strains of Enterobacteriaceae (Pseudomonas, Escherichia coli, Klebsiella) are resistant.<\/li>\n
For the latter, used in combination with enrofloxacin and rifampin.<\/li>\n<\/ul>\n
\n $\"Vet$ <\/a><\/div>\n\n
Dose of Clarithromycin (Biaxin) in Dogs and Cats<\/strong><\/h2>\n
Dogs:<\/strong><\/p>\n
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4\u201312 mg\/kg i.v. infusion, p.o. q12h<\/strong>. Doses of 15\u201325 mg\/kg p.o. total daily dose divided q8\u201312h is recommended in the treatment of leproid granuloma syndrome<\/strong> combined with rifampin 10\u201315 mg\/kg p.o. q24h.<\/li>\n
These doses are empirical and are based on only a few reports.<\/li>\n<\/ul>\n
Cats:<\/strong><\/p>\n
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5\u201310 mg\/kg i.v. infusion, p.o. q12h<\/strong> or 62.5 mg\/cat p.o.<\/li>\n
These doses are empirical and are based on only a few reports.<\/li>\n
A variety of combination protocols have been used in the treatment of feline leprosy syndrome<\/strong>, e.g. combination of clarithromycin with a fluoroquinolone and either rifampin or clofazamine.<\/li>\n<\/ul>\n
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Activity is enhanced in an alkaline pH; administer on an empty stomach.<\/li>\n<\/ul>\n
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