{"id":585,"date":"2023-02-24T16:11:32","date_gmt":"2023-02-24T14:11:32","guid":{"rendered":"https:\/\/www.vetdrugslist.com\/?p=585"},"modified":"2023-04-29T14:51:30","modified_gmt":"2023-04-29T14:51:30","slug":"ciclosporin","status":"publish","type":"post","link":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/ciclosporin\/","title":{"rendered":"Ciclosporin"},"content":{"rendered":"

Ciclosporin (Cyclosporine): Uses, Dosage and Side Effects<\/strong><\/p>\n

$\"Ciclosporin$ <\/p>\n\n

Overview<\/strong><\/h2>\n
The action of Ciclosporin is T-lymphocyte inhibition.<\/p>\n
Uses of Ciclosporin<\/strong><\/h2>\n
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Topical ophthalmic preparation for immune-mediated keratoconjunctivitis sicca in dogs.<\/li>\n
Used as an Immunosuppressant in chronic superficial keratoconjunctivitis (pannus).<\/li>\n
Oral preparation licensed for atopic dermatitis in dogs and cats.<\/li>\n
Used for perianal fistula, sebaceous adenitis, and immune-mediated disease.<\/li>\n<\/ul>\n
\n $\"Vet$ <\/a><\/div>\n\n
Dose of Ciclosporin in Dogs and Cats<\/strong><\/h2>\n
Dogs:<\/strong><\/p>\n
\u2022 Ocular disease:<\/strong> apply approximately 0.5 cm of ointment to the affected eye q12h. It may take 2\u20134 weeks for improvement to occur (occasionally up to 12 weeks). Maintenance treatment should be continued with application q12h; in cases of excessive tear production, the application can be reduced to q24h but only with caution and long-term, regular monitoring of tear production.
\n\u2022 Atopic dermatitis:<\/strong> 5 mg\/kg p.o. q24h until signs are controlled.
\n\u2022 Perianal fistula, sebaceous adenitis:<\/strong> 5 mg\/kg p.o. q24h \u2013 may be increased in non-responsive cases to q12h.
\n\u2022 Immune-mediated disease:<\/strong> 5 mg\/kg p.o. q12h. A proportion of dogs may require higher doses and pharmacodynamic monitoring is therefore advisable.<\/p>\n
Cats:<\/strong><\/p>\n
\u2022 Atopic dermatitis:<\/strong> 7 mg\/kg p.o. q24h until signs are controlled.
\n\u2022 Immune-mediated disease:<\/strong>\u00a0 3\u20135 mg\/kg p.o. q12h or 5\u20137 mg\/kg p.o. q24h.<\/p>\n
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