{"id":336,"date":"2023-02-02T14:08:04","date_gmt":"2023-02-02T12:08:04","guid":{"rendered":"https:\/\/www.vetdrugslist.com\/?p=336"},"modified":"2023-04-21T20:54:32","modified_gmt":"2023-04-21T20:54:32","slug":"bupivacaine","status":"publish","type":"post","link":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/bupivacaine\/","title":{"rendered":"Bupivacaine"},"content":{"rendered":"<p style=\"text-align: center; font-size: 24px; font-family: sans-serif;\"><strong>Bupivacaine: Uses, Dosage and Side Effects<\/strong><\/p>\n<h3><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-457 aligncenter\" src=\"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/02\/Bupivacaine.jpg\" alt=\"Bupivacaine: Uses, Dosage and Side Effects\" width=\"621\" height=\"373\" \/><\/h3>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Overview<\/strong><\/h2>\n<ul>\n<li>Reversible blockade of the sodium channel in nerve fibers produces local anesthesia.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Uses of Bupivacaine<\/strong><\/h2>\n<p>Provision of <strong>analgesia<\/strong> by perineural nerve blocks, <strong>regional<\/strong> and <strong>epidural<\/strong> techniques.<br \/>\n<div class='code-block code-block-12' style='margin: 8px auto; text-align: center; display: block; clear: both;'>\n<a target=\"_blank\" href=\"https:\/\/www.vet-ebooks.com\/premium-memberships\/\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-17003\" src=\"https:\/\/www.vet-ebooks.com\/wp-content\/uploads\/2024\/10\/veterinary-books-1.jpg\" width=\"480\" height=\"98\"  alt=\"Vet Books\"\/><\/a><\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Dose of Bupivacaine in Dogs and Cats<\/strong><\/h2>\n<p><strong>Dogs:<\/strong><\/p>\n<p><strong>\u2022 Perineural:<\/strong> <em>volume of injection depends on the site of placement and size of the animal<\/em>.<\/p>\n<ul>\n<li><strong> 0.1 ml\/kg<\/strong> per injection site for<strong> femoral and sciatic nerve blocks<\/strong>.<\/li>\n<li><strong>0.1 ml\/kg<\/strong> for each of the three injection sites for the combined<strong> radial, ulnar, musculocutaneous, and median nerve blocks.<\/strong><\/li>\n<li><strong>0.3 ml\/kg<\/strong> for <strong>brachial plexus nerve block.<\/strong><\/li>\n<li><strong>0.25\u20131 ml total volume<\/strong> for blockade of the <strong>infraorbital, mental, maxillary and mandibular nerves. <\/strong><\/li>\n<\/ul>\n<p>Choose an appropriate concentration of bupivacaine to achieve a 1\u20132 mg\/kg dose within these volume guidelines.<\/p>\n<p><strong>\u2022 Epidural:<\/strong><\/p>\n<ul>\n<li><strong>1.6 mg\/kg<\/strong> (analgesia to the level of L4).<\/li>\n<li><strong>2.3 mg\/kg<\/strong> (analgesia to the level of T11\u2013T13).<\/li>\n<li><strong>1 mg\/kg<\/strong> bupivacaine combined with preservative-free morphine 0.1\u20130.2 mg\/kg.<\/li>\n<\/ul>\n<p>Limit the total volume of solution injected into the <strong>epidural space<\/strong> to <strong>1 ml\/4.5 kg<\/strong> up to a <strong>maximum volume of 6 ml<\/strong> in order to limit the cranial distribution of drugs in the epidural space and prevent adverse pressure effects.<\/p>\n<p><strong>\u2022 Interpleural:<\/strong><\/p>\n<p><strong>1 mg\/kg<\/strong> diluted with normal saline to a total volume of <strong>5\u201320 ml<\/strong> depending on the size of the animal. The solution can be instilled via a <strong>thoracotomy tube<\/strong>. Dilution reduces pain on injection due to the acidity of bupivacaine.<\/p>\n<p><strong>Cats: <\/strong><\/p>\n<p>Doses as for dogs. Accurate dosing in cats is essential to prevent overdose.<br \/>\n<div class='code-block code-block-2' style='margin: 8px auto 8px 0; text-align: left; display: block; clear: both;'>\n <html>\n  <head>\n    <style>\n    \n \n      #calculator {\n        width: 100%;\n        margin: auto;\n      }\n      \n      @media (max-width: 600px) {\n        #calculator {\n          width: 90%;\n        }\n      }\n      \n      #calculator23 {\n        display: block;\n        margin-bottom: 8px;\n        font-size: 14px;\nfont-family: sans-serif;font-weight:600;\n      }\n      \n      #calculator24{\n        width: 100%;\n        padding: 12px 20px;\n        margin: 8px 0;\n        box-sizing: border-box;\n        border: 2px solid #ccc;\n        border-radius: 4px;\n      }\n      \n      #calculator25 {\n        width: 100%;\n    background-color: #fabd14;\n    color: white;\n    padding: 11px 18px;\n    margin: 5px 0;\n    border: none;\n    border-radius: 4px;\n    cursor: pointer;\n    font-size: 15px;\n    font-family: sans-serif;\n    font-weight: 600;\n}\n      }\n      \n      #result {\n        font-size: 18px;\n        font-weight: bold;\n      }\n    <\/style>\n  <\/head>\n  <body>\n  \n \n\n  <h2 style=\"border-bottom: 2px #fff7e6 solid;\" class=\"cd-section-title\"><span><strong>Drug Dosage Calculator<\/strong><\/span><\/h2>\n    <form id=\"calculator\">\n      <label id=\"calculator23\" for=\"weight\">Animal Weight (kg):<\/label>\n      <input type=\"text\" id=\"weight\" name=\"weight\" id=\"calculator24\">\n      <label for=\"dose\" id=\"calculator23\">Drug Dose (mg\/kg):<\/label>\n      <input type=\"text\" id=\"dose\" name=\"dose\" id=\"calculator24\">\n      <label for=\"concentration\" id=\"calculator23\">Drug Concentration (mg\/mL or mg\/tablet):<\/label>\n      <input type=\"text\" id=\"concentration\" name=\"concentration\" id=\"calculator24\">\n      <button type=\"button\" onclick=\"calculate()\" id=\"calculator25\">Calculate<\/button>\n    <\/form> \n    \n    <p style=\"\n    font-size: 13px;\n    font-weight: 600;\n    font-family: sans-serif;\n    background: #444;\n    padding: 5px;\n    border-radius: 5px;\n    color: #fff;\n\">You Should Give: <span id=\"result\"><\/span><\/p>\n\n\n    \n    <script>\n      function calculateDose(weight, dose, concentration) {\n        return (weight * dose \/ concentration).toFixed(2);\n      }\n      \n      function calculate() {\n        let weight = document.getElementById(\"weight\").value;\n        let dose = document.getElementById(\"dose\").value;\n        let concentration = document.getElementById(\"concentration\").value;\n        let result = calculateDose(weight, dose, concentration);\n        document.getElementById(\"result\").innerHTML = result + \" mL or tablet \";\n      }\n    <\/script>\n  <\/body>\n<\/html>\n<\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Side Effects of Bupivacaine in Dogs and Cats<\/strong><\/h2>\n<p>The inadvertent intravascular injection may precipitate severe cardiac arrhythmias that are refractory to treatment.<\/p>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Contraindications of Bupivacaine in Dogs and Cats<\/strong><\/h2>\n<ul>\n<li>Do not give i.v. or use for i.v. regional anesthesia.<\/li>\n<li>Use of bupivacaine with adrenaline is not recommended when local vasoconstriction is undesirable (e.g. end arterial sites) or when a significant degree of systemic absorption is likely.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Some Notes:<\/strong><\/h2>\n<ul>\n<li><strong>Onset of action<\/strong> is significantly<strong> slower<\/strong> than lidocaine (20\u201330 minutes for epidural analgesia) but <strong>duration of action is<\/strong> relatively <strong>prolonged<\/strong> (6\u20138 hours).<\/li>\n<li>Lower doses should be used when systemic absorption is likely to be high (e.g. intrapleural analgesia).<\/li>\n<li>Small volumes of bupivacaine can be diluted with normal saline to enable wider distribution of the drug for perineural blockade.<\/li>\n<li>Doses of bupivacaine up to 2 mg\/kg q8h are unlikely to be associated with systemic side effects if injected perineurally, epidurally or intrapleurally.<\/li>\n<li><strong>Combining bupivacaine with lidocaine<\/strong> can prolong the duration of the sensory block while limiting the duration of the motor block compared with the administration of bupivacaine alone.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Bupivacaine: Uses, Dosage and Side Effects Overview Reversible blockade of the sodium channel in nerve fibers produces local anesthesia. Uses of Bupivacaine Provision of analgesia by perineural nerve blocks, regional and epidural techniques. Dose of Bupivacaine in Dogs and Cats Dogs: \u2022 Perineural: volume of injection depends on the site of placement and size of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1118,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16,4],"tags":[],"class_list":["post-336","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-analgesics","category-anesthesia"],"_links":{"self":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/336","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/comments?post=336"}],"version-history":[{"count":0,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/336\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media\/1118"}],"wp:attachment":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media?parent=336"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/categories?post=336"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/tags?post=336"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}