{"id":2964,"date":"2024-05-12T23:24:03","date_gmt":"2024-05-12T20:24:03","guid":{"rendered":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/?p=2964"},"modified":"2024-05-12T23:24:03","modified_gmt":"2024-05-12T20:24:03","slug":"thiamazole-methimazole","status":"publish","type":"post","link":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/thiamazole-methimazole\/","title":{"rendered":"Thiamazole (Methimazole)"},"content":{"rendered":"

Thiamazole (Methimazole) In Dogs & Cats: Uses, Dosage and Side Effects<\/strong><\/p>\n

$\"Thiamazole$ <\/p>\n\n

Overview<\/strong><\/h2>\n
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Interferes with the synthesis of thyroid hormones by inhibiting peroxidase-catalysed reactions (blocks oxidation of iodide), the iodination of tyrosyl residues of thyroglobulin, and the coupling of mono- or di-iodotyrosines to form T3 and T4.<\/li>\n
Has no effect on iodine uptake, peripheral de-iodination of T4 to T3 or release of stored hormone.<\/li>\n<\/ul>\n
Uses of Thiamazole (Methimazole)<\/strong><\/h2>\n
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Control of thyroid hormone levels in cats with hyperthyroidism.<\/li>\n
Generally, 2 to 3 weeks of treatment are required to establish euthyroidism.<\/li>\n
Monitor therapy based on serum thyroxine concentrations (4\u20136 hours after dosing) and adjust dose accordingly for long-term management.<\/li>\n
Assess hematological and biochemical parameters, along with serum total T4 levels, after 3, 6, 10, and 20 weeks, then every 3 months thereafter, adjusting dosage as necessary.<\/li>\n
Transdermal thiamazole gels are also used, especially in fractious cats or those experiencing GI side effects from oral formulations. However, this route is not as reliable or safe for humans applying the gel.<\/li>\n<\/ul>\n
\n $\"Vet$ <\/a><\/div>\n\n
Dose of Thiamazole (Methimazole) in Dogs and Cats<\/strong><\/h2>\n
Dogs: <\/strong><\/p>\n
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Hyperthyroidism<\/span>: 2.5\u20135 mg\/dog p.o. q12h depending on size.<\/li>\n<\/ul>\n
Cats:<\/strong><\/p>\n
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Hyperthyroidism<\/span>: 2.5 mg\/cat p.o. q12h.<\/li>\n
Apply transdermal gel to pinna.<\/li>\n<\/ul>\n
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