{"id":2948,"date":"2024-07-22T12:56:20","date_gmt":"2024-07-22T09:56:20","guid":{"rendered":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/?p=2948"},"modified":"2024-07-25T20:19:52","modified_gmt":"2024-07-25T17:19:52","slug":"tolfenamic-acid","status":"publish","type":"post","link":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/tolfenamic-acid\/","title":{"rendered":"Tolfenamic Acid"},"content":{"rendered":"<p style=\"text-align: center; font-size: 24px; font-family: sans-serif;\"><strong>Tolfenamic Acid In Dogs &amp; Cats: Uses, Dosage and Side Effects<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-3061\" src=\"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2024\/07\/Tolfenamic-Acid.jpg\" alt=\"Tolfenamic Acid In Dogs &amp; Cats: Uses, Dosage and Side Effects\" width=\"800\" height=\"480\" srcset=\"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2024\/07\/Tolfenamic-Acid.jpg 800w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2024\/07\/Tolfenamic-Acid-300x180.jpg 300w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2024\/07\/Tolfenamic-Acid-768x461.jpg 768w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2024\/07\/Tolfenamic-Acid-696x418.jpg 696w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2024\/07\/Tolfenamic-Acid-700x420.jpg 700w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/p>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Overview<\/strong><\/h2>\n<ul>\n<li>It inhibits cyclo-oxygenase, but unclear if it preferentially inhibits COX-2 over COX-1.<\/li>\n<li>COX inhibition reduces the production of prostaglandins associated with inflammation.<\/li>\n<li>Additionally, reported to directly antagonize prostaglandin receptors.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Uses of Tolfenamic acid<\/strong><\/h2>\n<p>\u2022 Alleviation of inflammation and pain in dogs and cats.<br \/>\n\u2022 Also used in the management of chronic locomotor disease in dogs.<br \/>\n\u2022 Management of fever.<\/p>\n<div class='code-block code-block-12' style='margin: 8px auto; text-align: center; display: block; clear: both;'>\n<a target=\"_blank\" href=\"https:\/\/www.vet-ebooks.com\/premium-memberships\/\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-17003\" src=\"https:\/\/www.vet-ebooks.com\/wp-content\/uploads\/2024\/10\/veterinary-books-1.jpg\" width=\"480\" height=\"98\"  alt=\"Vet Books\"\/><\/a><\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Dose of Tolfenamic acid in Dogs and Cats<\/strong><\/h2>\n<p><strong>Dogs: <\/strong><\/p>\n<ul>\n<li>4 mg\/kg i.m., s.c., may be repeated once after 24 hours; 4 mg\/kg p.o. for 3 days.<\/li>\n<li>Treatment starts with a single injection on day 1.<\/li>\n<li>The oral dosage regimen may be repeated once a week (i.e. 4 days of treatment with 3 days rest).<\/li>\n<\/ul>\n<p><strong>Cats: <\/strong><\/p>\n<ul>\n<li>4 mg\/kg s.c., may be repeated once after 24 hours; 4 mg\/kg p.o. for 3 days.<\/li>\n<li>Treatment starts with a single injection on day 1.<\/li>\n<li>Repeated dosing on a weekly basis is not recommended in cats.<\/li>\n<\/ul>\n<div class='code-block code-block-2' style='margin: 8px auto 8px 0; text-align: left; display: block; clear: both;'>\n <html>\n  <head>\n    <style>\n    \n \n      #calculator {\n        width: 100%;\n        margin: auto;\n      }\n      \n      @media (max-width: 600px) {\n        #calculator {\n          width: 90%;\n        }\n      }\n      \n      #calculator23 {\n        display: block;\n        margin-bottom: 8px;\n        font-size: 14px;\nfont-family: sans-serif;font-weight:600;\n      }\n      \n      #calculator24{\n        width: 100%;\n        padding: 12px 20px;\n        margin: 8px 0;\n        box-sizing: border-box;\n        border: 2px solid #ccc;\n        border-radius: 4px;\n      }\n      \n      #calculator25 {\n        width: 100%;\n    background-color: #fabd14;\n    color: white;\n    padding: 11px 18px;\n    margin: 5px 0;\n    border: none;\n    border-radius: 4px;\n    cursor: pointer;\n    font-size: 15px;\n    font-family: sans-serif;\n    font-weight: 600;\n}\n      }\n      \n      #result {\n        font-size: 18px;\n        font-weight: bold;\n      }\n    <\/style>\n  <\/head>\n  <body>\n  \n \n\n  <h2 style=\"border-bottom: 2px #fff7e6 solid;\" class=\"cd-section-title\"><span><strong>Drug Dosage Calculator<\/strong><\/span><\/h2>\n    <form id=\"calculator\">\n      <label id=\"calculator23\" for=\"weight\">Animal Weight (kg):<\/label>\n      <input type=\"text\" id=\"weight\" name=\"weight\" id=\"calculator24\">\n      <label for=\"dose\" id=\"calculator23\">Drug Dose (mg\/kg):<\/label>\n      <input type=\"text\" id=\"dose\" name=\"dose\" id=\"calculator24\">\n      <label for=\"concentration\" id=\"calculator23\">Drug Concentration (mg\/mL or mg\/tablet):<\/label>\n      <input type=\"text\" id=\"concentration\" name=\"concentration\" id=\"calculator24\">\n      <button type=\"button\" onclick=\"calculate()\" id=\"calculator25\">Calculate<\/button>\n    <\/form> \n    \n    <p style=\"\n    font-size: 13px;\n    font-weight: 600;\n    font-family: sans-serif;\n    background: #444;\n    padding: 5px;\n    border-radius: 5px;\n    color: #fff;\n\">You Should Give: <span id=\"result\"><\/span><\/p>\n\n\n    \n    <script>\n      function calculateDose(weight, dose, concentration) {\n        return (weight * dose \/ concentration).toFixed(2);\n      }\n      \n      function calculate() {\n        let weight = document.getElementById(\"weight\").value;\n        let dose = document.getElementById(\"dose\").value;\n        let concentration = document.getElementById(\"concentration\").value;\n        let result = calculateDose(weight, dose, concentration);\n        document.getElementById(\"result\").innerHTML = result + \" mL or tablet \";\n      }\n    <\/script>\n  <\/body>\n<\/html>\n<\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Side Effects of Tolfenamic acid in Dogs and Cats<\/strong><\/h2>\n<ul>\n<li>GI signs are common in all animals after NSAID administration; discontinue therapy if signs persist beyond 1\u20132 days.<\/li>\n<li>Sensitivity to NSAIDs varies among animals; some may react to one NSAID but not another.<\/li>\n<li>Allow a 3\u20135-day washout period before starting another NSAID after discontinuing therapy.<\/li>\n<li>Cease therapy immediately if GI bleeding is suspected.<\/li>\n<li>The risk of NSAIDs precipitating cardiac failure in animals is unclear, though a small risk exists in humans.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Contraindications of Tolfenamic acid in Dogs and Cats<\/strong><\/h2>\n<ul>\n<li>Do not give to dehydrated, hypovolaemic or hypotensive patients or those with GI disease or blood clotting problems.<\/li>\n<li>Do not give to pregnant animals or animals &lt;6 weeks old.<\/li>\n<li>Do not give i.m. to cats.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Some Notes:<\/strong><\/h2>\n<ul>\n<li>Injectable tolfenamic acid is approved for preoperative use in cats and dogs.<\/li>\n<li>Liver disease can prolong metabolism, leading to potential accumulation and overdose with repeated dosing.<\/li>\n<li>In cats, due to longer half-life and narrower therapeutic index, careful dosing is crucial, and using a 1 ml graduated syringe is recommended for accurate measurement.<\/li>\n<li>Use cautiously in renal diseases and perioperative periods, as it may affect renal perfusion during hypotension.<\/li>\n<li>Emerging evidence suggests that tolfenamic acid may have anticancer activity against certain tumor types based on in vitro models and dog tumor cell lines.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Tolfenamic Acid In Dogs &amp; Cats: Uses, Dosage and Side Effects Overview It inhibits cyclo-oxygenase, but unclear if it preferentially inhibits COX-2 over COX-1. COX inhibition reduces the production of prostaglandins associated with inflammation. Additionally, reported to directly antagonize prostaglandin receptors. Uses of Tolfenamic acid \u2022 Alleviation of inflammation and pain in dogs and cats. [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":3061,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[46],"tags":[],"class_list":["post-2948","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-anti-inflammatory-drugs"],"_links":{"self":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/2948","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/comments?post=2948"}],"version-history":[{"count":0,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/2948\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media\/3061"}],"wp:attachment":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media?parent=2948"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/categories?post=2948"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/tags?post=2948"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}