{"id":2913,"date":"2024-05-14T23:27:29","date_gmt":"2024-05-14T20:27:29","guid":{"rendered":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/?p=2913"},"modified":"2024-05-12T23:42:49","modified_gmt":"2024-05-12T20:42:49","slug":"verapamil","status":"publish","type":"post","link":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/verapamil\/","title":{"rendered":"Verapamil"},"content":{"rendered":"

Verapamil In Dogs & Cats: Uses, Dosage and Side Effects<\/strong><\/p>\n

$\"Verapamil$ <\/p>\n\n

Overview<\/strong><\/h2>\n
Verapamil works by blocking the inward movement of calcium ions through slow (L-type) calcium channels in myocardial cells, cardiac conduction tissue, and vascular smooth muscle. This action leads to several effects:<\/p>\n
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Reduction in myocardial contractility, resulting in negative inotropy.<\/li>\n
Depression of electrical activity, leading to slowed atrioventricular (AV) conduction.<\/li>\n
Vasodilation of cardiac vessels, peripheral arteries, and arterioles.<\/li>\n<\/ul>\n
Uses of Verapamil<\/strong><\/h2>\n
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Verapamil is mainly used for supraventricular tachyarrhythmias like accessory pathway-mediated SVT, atrial tachycardia, and flutter.<\/li>\n
It’s considered a secondary option among calcium-channel blockers, after diltiazem, due to its stronger negative inotropic effect.<\/li>\n
Patients with severe hepatic disease may need a 70% dose reduction due to reduced drug metabolism capacity.<\/li>\n<\/ul>\n
\n $\"Vet$ <\/a><\/div>\n\n
Dose of Verapamil in Dogs and Cats<\/strong><\/h2>\n
Dogs: <\/strong><\/p>\n
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0.5\u20133 mg\/kg p.o. q8h or 0.05 mg\/kg slowly i.v. over 5 minutes (with ECG monitoring).<\/li>\n
Up to 4 repeat i.v. administrations at a reduced dose of 0.025 mg\/kg q5min if necessary.<\/li>\n<\/ul>\n
Cats: <\/strong><\/p>\n
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0.5\u20131 mg\/kg p.o. q8h or 0.025 mg\/kg slowly i.v. over 5 minutes (with ECG monitoring).<\/li>\n
Up to 3 repeat i.v. administrations q5min if necessary.<\/li>\n<\/ul>\n
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