{"id":2629,"date":"2024-02-05T21:29:26","date_gmt":"2024-02-05T19:29:26","guid":{"rendered":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/?p=2629"},"modified":"2024-02-03T21:33:57","modified_gmt":"2024-02-03T19:33:57","slug":"spironolactone","status":"publish","type":"post","link":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/spironolactone\/","title":{"rendered":"Spironolactone"},"content":{"rendered":"

Spironolactone In Dogs & Cats: Uses, Dosage and Side Effects<\/strong><\/p>\n

$\"Spironolactone$ <\/p>\n\n

Overview<\/strong><\/h2>\n
\n
Aldosterone receptor antagonist.<\/li>\n
Acts on the kidneys as a weak potassium-sparing diuretic.<\/li>\n
Prevents sodium resorption in the distal tubule.<\/li>\n
Works by competing with aldosterone for the mineralocorticoid receptor in the principle cells of the collecting duct.<\/li>\n
Acts on the myocardium and vasculature.<\/li>\n
Inhibits aldosterone-mediated fibrosis and remodeling.<\/li>\n<\/ul>\n
Uses of Spironolactone<\/strong><\/h2>\n
\n
Treatment of congestive heart failure. Licensed for use in combination with standard therapy for the treatment of CHF caused by valvular regurgitation in dogs.<\/li>\n
Used in the management of ascites secondary to hepatic failure (when hypokalaemia can exacerbate hepatic encephalopathy).<\/li>\n
Treatment of hyperaldosteronism due to adrenal tumours.<\/li>\n<\/ul>\n
\n $\"Vet$ <\/a><\/div>\n\n
Dose of Spironolactone in Dogs and Cats<\/strong><\/h2>\n
Dogs, Cats: <\/strong><\/p>\n
\n
2\u20134 mg\/kg p.o. q24h.<\/li>\n<\/ul>\n
\n \n \n