{"id":2625,"date":"2024-01-31T11:54:55","date_gmt":"2024-01-31T09:54:55","guid":{"rendered":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/?p=2625"},"modified":"2024-01-31T11:54:55","modified_gmt":"2024-01-31T09:54:55","slug":"sotalol","status":"publish","type":"post","link":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/sotalol\/","title":{"rendered":"Sotalol"},"content":{"rendered":"<p style=\"text-align: center; font-size: 24px; font-family: sans-serif;\"><strong>Sotalol In Dogs &amp; Cats: Uses, Dosage and Side Effects<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-2681\" src=\"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2024\/01\/Sotalol.jpg\" alt=\"Sotalol In Dogs &amp; Cats: Uses, Dosage and Side Effects\" width=\"800\" height=\"480\" srcset=\"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2024\/01\/Sotalol.jpg 800w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2024\/01\/Sotalol-300x180.jpg 300w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2024\/01\/Sotalol-768x461.jpg 768w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2024\/01\/Sotalol-696x418.jpg 696w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2024\/01\/Sotalol-700x420.jpg 700w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/p>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Overview<\/strong><\/h2>\n<ul>\n<li>Produces a prolongation of action potential duration and refractory period, via selective inhibition of potassium channels (Class III antiarrhythmic).<\/li>\n<li>Also has non-selective beta-adrenergic blocking effects, but considered a weak beta-blocker.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Uses of Sotalol<\/strong><\/h2>\n<ul>\n<li>Treatment of ventricular arrhythmias, less so supraventricular arrhythmia (most associated with accessory pathway).<\/li>\n<li>Used most commonly in dogs with ventricular arrhythmias secondary to myocardial disease.<\/li>\n<\/ul>\n<div class='code-block code-block-12' style='margin: 8px auto; text-align: center; display: block; clear: both;'>\n<a target=\"_blank\" href=\"https:\/\/www.vet-ebooks.com\/premium-memberships\/\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-17003\" src=\"https:\/\/www.vet-ebooks.com\/wp-content\/uploads\/2024\/10\/veterinary-books-1.jpg\" width=\"480\" height=\"98\"  alt=\"Vet Books\"\/><\/a><\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Dose of Sotalol in Dogs and Cats<\/strong><\/h2>\n<p><strong>Dogs: <\/strong><\/p>\n<ul>\n<li>0.5\u20133 mg\/kg p.o. q12h. Start with lower doses if myocardial function is reduced.<\/li>\n<li>Anecdotal doses starting at 0.5 mg\/kg i.v. given over 2 min, up to 3 times (to a total dose of 1.5 mg\/kg i.v.).<\/li>\n<\/ul>\n<p><strong>Cats: <\/strong><\/p>\n<ul>\n<li>10\u201320 mg\/cat p.o. q12h.<\/li>\n<\/ul>\n<div class='code-block code-block-2' style='margin: 8px auto 8px 0; text-align: left; display: block; clear: both;'>\n <html>\n  <head>\n    <style>\n    \n \n      #calculator {\n        width: 100%;\n        margin: auto;\n      }\n      \n      @media (max-width: 600px) {\n        #calculator {\n          width: 90%;\n        }\n      }\n      \n      #calculator23 {\n        display: block;\n        margin-bottom: 8px;\n        font-size: 14px;\nfont-family: sans-serif;font-weight:600;\n      }\n      \n      #calculator24{\n        width: 100%;\n        padding: 12px 20px;\n        margin: 8px 0;\n        box-sizing: border-box;\n        border: 2px solid #ccc;\n        border-radius: 4px;\n      }\n      \n      #calculator25 {\n        width: 100%;\n    background-color: #fabd14;\n    color: white;\n    padding: 11px 18px;\n    margin: 5px 0;\n    border: none;\n    border-radius: 4px;\n    cursor: pointer;\n    font-size: 15px;\n    font-family: sans-serif;\n    font-weight: 600;\n}\n      }\n      \n      #result {\n        font-size: 18px;\n        font-weight: bold;\n      }\n    <\/style>\n  <\/head>\n  <body>\n  \n \n\n  <h2 style=\"border-bottom: 2px #fff7e6 solid;\" class=\"cd-section-title\"><span><strong>Drug Dosage Calculator<\/strong><\/span><\/h2>\n    <form id=\"calculator\">\n      <label id=\"calculator23\" for=\"weight\">Animal Weight (kg):<\/label>\n      <input type=\"text\" id=\"weight\" name=\"weight\" id=\"calculator24\">\n      <label for=\"dose\" id=\"calculator23\">Drug Dose (mg\/kg):<\/label>\n      <input type=\"text\" id=\"dose\" name=\"dose\" id=\"calculator24\">\n      <label for=\"concentration\" id=\"calculator23\">Drug Concentration (mg\/mL or mg\/tablet):<\/label>\n      <input type=\"text\" id=\"concentration\" name=\"concentration\" id=\"calculator24\">\n      <button type=\"button\" onclick=\"calculate()\" id=\"calculator25\">Calculate<\/button>\n    <\/form> \n    \n    <p style=\"\n    font-size: 13px;\n    font-weight: 600;\n    font-family: sans-serif;\n    background: #444;\n    padding: 5px;\n    border-radius: 5px;\n    color: #fff;\n\">You Should Give: <span id=\"result\"><\/span><\/p>\n\n\n    \n    <script>\n      function calculateDose(weight, dose, concentration) {\n        return (weight * dose \/ concentration).toFixed(2);\n      }\n      \n      function calculate() {\n        let weight = document.getElementById(\"weight\").value;\n        let dose = document.getElementById(\"dose\").value;\n        let concentration = document.getElementById(\"concentration\").value;\n        let result = calculateDose(weight, dose, concentration);\n        document.getElementById(\"result\").innerHTML = result + \" mL or tablet \";\n      }\n    <\/script>\n  <\/body>\n<\/html>\n<\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Side Effects of Sotalol in Dogs and Cats<\/strong><\/h2>\n<ul>\n<li>Non-selective beta-blocking effects in dogs can reduce heart rate, stroke volume, and cardiac output, potentially leading to congestive heart failure.<\/li>\n<li>The drug is excreted through urine and feces, and its elimination half-life may extend with renal insufficiency, resulting in accumulation at standard doses.<\/li>\n<li>Adverse effects encompass hypotension, bradyarrhythmias, bronchospasm, depression, as well as nausea, vomiting, and diarrhea.<\/li>\n<li>The drug carries a proarrhythmic potential, and elevated doses can prolong the QT interval, heightening the risk of torsades de pointes, especially in the presence of hypokalemia.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Contraindications of Sotalol in Dogs and Cats<\/strong><\/h2>\n<ul>\n<li>Asthma, sinus bradycardia, AV block or decompensated CH, long QT on ECG.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Some Notes:<\/strong><\/h2>\n<ul>\n<li>Sympathomimetics such as terbutaline, phenylpropanolamine, and adrenaline may have their effects blocked by sotalol, potentially reducing its efficacy.<\/li>\n<li>Concurrent use of sotalol with other beta-blockers or myocardial depressant anesthetic agents can lead to additive myocardial depression.<\/li>\n<li>Hypotensive effects of sotalol may be enhanced when used alongside phenothiazines, furosemide, hydralazine, and other vasodilators.<\/li>\n<li>Sotalol may prolong the hypoglycemic effects of insulin therapy.<\/li>\n<li>Caution should be exercised when using negative inotropics (e.g., calcium-channel blockers) concurrently with sotalol, especially in patients with pre-existing systolic dysfunction or congestive heart failure (CHF).<\/li>\n<li>Beta-blocking activity of the drug is approximately one-third of that of propranolol.<\/li>\n<li>Efficacy assessment is preferably done through repeated Holter ECG monitoring.<\/li>\n<li>Successful combination use with mexilitine is possible for treating severe ventricular arrhythmia.<\/li>\n<li>Caution is advised when using the drug in patients with renal failure or medically controlled congestive heart failure (CHF).\n<div class=\"flex-1 overflow-hidden\">\n<div class=\"react-scroll-to-bottom--css-wwyzl-79elbk h-full\">\n<div class=\"react-scroll-to-bottom--css-wwyzl-1n7m0yu\">\n<div class=\"flex flex-col pb-9 text-sm\">\n<div class=\"w-full text-token-text-primary\" data-testid=\"conversation-turn-13\">\n<div class=\"px-4 py-2 justify-center text-base md:gap-6 m-auto\">\n<div class=\"flex flex-1 text-base mx-auto gap-3 md:px-5 lg:px-1 xl:px-5 md:max-w-3xl lg:max-w-[40rem] xl:max-w-[48rem] group final-completion\">\n<div class=\"relative flex w-full flex-col lg:w-[calc(100%-115px)] agent-turn\">\n<div class=\"flex-col gap-1 md:gap-3\">\n<div class=\"flex flex-grow flex-col max-w-full\">\n<div class=\"min-h-[20px] text-message flex flex-col items-start gap-3 whitespace-pre-wrap break-words [.text-message+&amp;]:mt-5 overflow-x-auto\" data-message-author-role=\"assistant\" data-message-id=\"bacfb3cb-eb91-4db1-a531-d57adbfed1f1\">\n<div class=\"markdown prose w-full break-words dark:prose-invert light\"><\/div>\n<\/div>\n<\/div>\n<div class=\"mt-1 flex justify-start gap-3 empty:hidden\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"w-full pt-2 md:pt-0 dark:border-white\/20 md:border-transparent md:dark:border-transparent md:w-[calc(100%-.5rem)]\">\n<div class=\"relative flex h-full flex-1 items-stretch md:flex-col\">\n<div class=\"flex w-full items-center\">\n<div class=\"overflow-hidden [&amp;:has(textarea:focus)]:border-token-border-xheavy [&amp;:has(textarea:focus)]:shadow-[0_2px_6px_rgba(0,0,0,.05)] flex flex-col w-full dark:border-token-border-heavy flex-grow relative border border-token-border-heavy dark:text-white rounded-2xl bg-white dark:bg-gray-800 shadow-[0_0_0_2px_rgba(255,255,255,0.95)] dark:shadow-[0_0_0_2px_rgba(52,53,65,0.95)]\">\n<div data-grammarly-part=\"button\">\n<div>\n<div>\n<div class=\"amkYk\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Sotalol In Dogs &amp; Cats: Uses, Dosage and Side Effects Overview Produces a prolongation of action potential duration and refractory period, via selective inhibition of potassium channels (Class III antiarrhythmic). Also has non-selective beta-adrenergic blocking effects, but considered a weak beta-blocker. Uses of Sotalol Treatment of ventricular arrhythmias, less so supraventricular arrhythmia (most associated with [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2681,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-2625","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cardiovascular"],"_links":{"self":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/2625","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/comments?post=2625"}],"version-history":[{"count":0,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/2625\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media\/2681"}],"wp:attachment":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media?parent=2625"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/categories?post=2625"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/tags?post=2625"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}