{"id":256,"date":"2023-01-20T19:18:18","date_gmt":"2023-01-20T17:18:18","guid":{"rendered":"https:\/\/www.vetdrugslist.com\/?p=256"},"modified":"2025-05-17T01:48:16","modified_gmt":"2025-05-16T22:48:16","slug":"amlodipine-dose","status":"publish","type":"post","link":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/amlodipine-dose\/","title":{"rendered":"Amlodipine"},"content":{"rendered":"<p style=\"text-align: center; font-size: 24px; font-family: sans-serif;\"><strong>Amlodipine for Dogs, Cats, and Birds: Dosage, Uses, and Side Effects Guide<br \/>\n<\/strong><\/p>\n<h3><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-383 aligncenter\" src=\"https:\/\/www.vet-ebooks.com\/wp-content\/uploads\/2024\/12\/amlodipine-for-dogs-cats-and-birds-dosage-uses-and-side-effects-guide.jpg\" alt=\"Amlodipine for Dogs, Cats, and Birds: Dosage, Uses, and Side Effects Guide\" width=\"643\" height=\"386\" \/><\/h3>\n\n<h2 id=\"cd-understanding\" class=\"cd-section-title\" style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Overview<\/strong><\/h2>\n<ul>\n<li><strong> Calcium-channel antagonist<\/strong>, with predominant action affecting peripheral arteriolar vasculature, causing vasodilation and reducing afterload.<\/li>\n<li>Has mild <strong>negative inotropic and chronotropic effects<\/strong>, which are negligible at therapeutic doses.<\/li>\n<\/ul>\n<h2 id=\"cd-understanding\" class=\"cd-section-title\" style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Uses of Amlodipine<\/strong><\/h2>\n<ul>\n<li><strong>Cats<\/strong>:\n<ul>\n<li>Management of systemic hypertension, including hypertension secondary to chronic kidney disease, hyperthyroidism, or hyperadrenocorticism.<\/li>\n<li>Reduction of proteinuria in hypertensive cats.<\/li>\n<li>Restores vision in some cases of hypertensive retinopathy.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Dogs<\/strong>:\n<ul>\n<li>Treatment of systemic hypertension, often secondary to renal disease or hyperadrenocorticism.<\/li>\n<li>Adjunctive therapy in refractory heart failure for afterload reduction.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Birds<\/strong>:\n<ul>\n<li>Management of systemic hypertension (e.g., psittacines). Limited studies suggest its efficacy in avian species.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<div class='code-block code-block-20' style='margin: 8px auto; text-align: center; display: block; clear: both;'>\n<a href=\"https:\/\/www.vet-ebooks.com\/premium-memberships\/\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17003\" src=\"https:\/\/www.vet-ebooks.com\/wp-content\/uploads\/2024\/10\/veterinary-books-1.jpg\" width=\"480\" height=\"98\"  alt=\"Vet Books\"\/><\/a><\/div>\n\n<h2 id=\"cd-understanding\" class=\"cd-section-title\" style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Dose of Amlodipine<\/strong><\/h2>\n<h3><strong>Dose of Amlodipine In Dogs<\/strong>:<\/h3>\n<ul>\n<li>Initial dose: 0.05\u20130.1 mg\/kg p.o. q12\u201324h.<\/li>\n<li>Gradual titration up to 0.5 mg\/kg\/day, based on blood pressure response.<\/li>\n<li>Monitoring: Regular blood pressure checks during dose adjustments.<\/li>\n<\/ul>\n<h3><strong>Dose of Amlodipine In Cats<\/strong>:<\/h3>\n<ul>\n<li>Initial dose: 0.625\u20131.25 mg\/cat p.o. q24h (not mg\/kg).<\/li>\n<li>Adjustments:\n<ul>\n<li>If blood pressure remains &gt;150 mmHg, increase dose or frequency to q12h.<\/li>\n<li>Monitor systolic blood pressure to maintain target levels (\u2264150 mmHg).<\/li>\n<\/ul>\n<\/li>\n<li>Maximum dose: Up to 2.5 mg\/cat\/day in severe hypertension.<\/li>\n<\/ul>\n<h3><strong>Dose of Amlodipine In Birds<\/strong>:<\/h3>\n<ul>\n<li>Initial dose: 0.4 mg\/kg p.o. q24h.<\/li>\n<li>Adjust dose based on blood pressure monitoring and clinical response.<\/li>\n<\/ul>\n<div class='code-block code-block-30' style='margin: 8px 0; clear: both;'>\n <html>\n  <head>\n    <style>\n    \n \n      #calculator {\n        width: 100%;\n        margin: auto;\n      }\n      \n      @media (max-width: 600px) {\n        #calculator {\n          width: 90%;\n        }\n      }\n      \n      #calculator23 {\n        display: block;\n        margin-bottom: 8px;\n        font-size: 14px;\nfont-family: sans-serif;font-weight:600;\n      }\n      \n      #calculator24{\n        width: 100%;\n        padding: 12px 20px;\n        margin: 8px 0;\n        box-sizing: border-box;\n        border: 2px solid #ccc;\n        border-radius: 4px;\n      }\n      \n      #calculator25 {\n        width: 100%;\n    background-color: #fabd14;\n    color: white;\n    padding: 11px 18px;\n    margin: 5px 0;\n    border: none;\n    border-radius: 4px;\n    cursor: pointer;\n    font-size: 15px;\n    font-family: sans-serif;\n    font-weight: 600;\n}\n      }\n      \n      #result {\n        font-size: 18px;\n        font-weight: bold;\n      }\n    <\/style>\n  <\/head>\n  <body>\n  \n \n\n  <h2 style=\"border-bottom: 2px #fabd14 solid;font-size: 20px;\" id=\"cd-understanding\" class=\"cd-section-title\"><span><strong>Drug Dosage Calculator<\/strong><\/span><\/h2>\n    <form id=\"calculator\">\n      <label id=\"calculator23\" for=\"weight\">Animal Weight (kg):<\/label>\n      <input type=\"text\" id=\"weight\" name=\"weight\" id=\"calculator24\">\n      <label for=\"dose\" id=\"calculator23\">Drug Dose (mg\/kg):<\/label>\n      <input type=\"text\" id=\"dose\" name=\"dose\" id=\"calculator24\">\n      <label for=\"concentration\" id=\"calculator23\">Drug Concentration (mg\/mL or mg\/tablet):<\/label>\n      <input type=\"text\" id=\"concentration\" name=\"concentration\" id=\"calculator24\">\n      <button type=\"button\" onclick=\"calculate()\" id=\"calculator25\">Calculate<\/button>\n    <\/form> \n    \n    <p style=\"\n    font-size: 13px;\n    font-weight: 600;\n    font-family: sans-serif;\n    background: #444;\n    padding: 5px;\n    border-radius: 5px;\n    color: #fff;\n\">You Should Give: <span id=\"result\"><\/span><\/p>\n\n\n    \n    <script>\n      function calculateDose(weight, dose, concentration) {\n        return (weight * dose \/ concentration).toFixed(2);\n      }\n      \n      function calculate() {\n        let weight = document.getElementById(\"weight\").value;\n        let dose = document.getElementById(\"dose\").value;\n        let concentration = document.getElementById(\"concentration\").value;\n        let result = calculateDose(weight, dose, concentration);\n        document.getElementById(\"result\").innerHTML = result + \" mL or tablet \";\n      }\n    <\/script>\n  <\/body>\n<\/html>\n<\/div>\n\n<h2 id=\"cd-understanding\" class=\"cd-section-title\" style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Side Effects of Amlodipine<\/strong><\/h2>\n<ul>\n<li><strong>Common side effects<\/strong>:\n<ul>\n<li>Lethargy, hypotension, and inappetence (mild and rare).<\/li>\n<li>Reversible gingival hyperplasia in long-term use, more commonly observed in dogs.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Less common side effects<\/strong>:\n<ul>\n<li>Reflex tachycardia.<\/li>\n<li>Mild azotemia, hypokalemia, or weight loss in cats.<\/li>\n<li>Peripheral edema reported in dogs.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Birds<\/strong>:\n<ul>\n<li>Limited data; no significant adverse effects reported at therapeutic doses.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 id=\"cd-understanding\" class=\"cd-section-title\" style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Contraindications of Amlodipine<\/strong><\/h2>\n<p><strong>Avoid use in:<\/strong><\/p>\n<ol>\n<li>Patients with:\n<ul>\n<li>Cardiogenic shock or severe hepatic failure.<\/li>\n<li>Severe aortic stenosis (risk of inadequate cardiac output due to vasodilation).<\/li>\n<li>Documented hypotension.<\/li>\n<\/ul>\n<\/li>\n<li>Pregnant or lactating animals due to a lack of established safety data.<\/li>\n<\/ol>\n<h2 id=\"cd-understanding\" class=\"cd-section-title\" style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Some Notes:<\/strong><\/h2>\n<ul>\n<li><strong>Hepatic Considerations<\/strong>:\n<ul>\n<li>Amlodipine is extensively metabolized in the liver; dosage adjustments are essential in hepatic disease.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Combination Therapy<\/strong>:\n<ul>\n<li>When used alone in dogs, amlodipine may activate the RAAS, leading to glomerular hypertension. Combining with an ACE inhibitor (e.g., enalapril or benazepril) mitigates this risk.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Monitoring<\/strong>:\n<ul>\n<li>Blood pressure monitoring is critical, particularly during dose titration.<\/li>\n<li>Fundic exams are recommended to assess for hypertensive retinopathy and retinal detachment.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Proteinuria Management<\/strong>:\n<ul>\n<li>In cats, amlodipine can reduce proteinuria associated with hypertension, improving survival.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Amlodipine for Dogs, Cats, and Birds: Dosage, Uses, and Side Effects Guide Overview Calcium-channel antagonist, with predominant action affecting peripheral arteriolar vasculature, causing vasodilation and reducing afterload. Has mild negative inotropic and chronotropic effects, which are negligible at therapeutic doses. Uses of Amlodipine Cats: Management of systemic hypertension, including hypertension secondary to chronic kidney disease, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1046,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[36],"class_list":["post-256","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cardiovascular","tag-calcium-channel-blocker"],"_links":{"self":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/256","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/comments?post=256"}],"version-history":[{"count":0,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/256\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media\/1046"}],"wp:attachment":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media?parent=256"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/categories?post=256"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/tags?post=256"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}