{"id":2378,"date":"2023-12-02T00:56:51","date_gmt":"2023-12-01T22:56:51","guid":{"rendered":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/?p=2378"},"modified":"2023-12-02T00:57:28","modified_gmt":"2023-12-01T22:57:28","slug":"penicillamine","status":"publish","type":"post","link":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/penicillamine\/","title":{"rendered":"Penicillamine"},"content":{"rendered":"<p style=\"text-align: center; font-size: 24px; font-family: sans-serif;\"><strong>Penicillamine In Dogs &amp; Cats: Uses, Dosage and Side Effects<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-2403\" src=\"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/11\/Penicillamine.jpg\" alt=\"\" width=\"800\" height=\"480\" srcset=\"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/11\/Penicillamine.jpg 800w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/11\/Penicillamine-300x180.jpg 300w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/11\/Penicillamine-768x461.jpg 768w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/11\/Penicillamine-696x418.jpg 696w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/11\/Penicillamine-700x420.jpg 700w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/p>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Overview<\/strong><\/h2>\n<ul>\n<li>Penicillamine is an orally administered chelating agent that binds copper, mercury and lead.<\/li>\n<li>It also binds to cystine.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Uses of Penicillamine<\/strong><\/h2>\n<ul>\n<li><strong>Management of copper storage disease<\/strong> in Bedlington Terriers and copper-associated hepatopathy in other susceptible breeds.<\/li>\n<li>Penicillamine is<strong> not effective<\/strong> in acute crises due to the slow process of copper chelation, which takes weeks to months.<\/li>\n<li><strong>Cystinuria treatment<\/strong>: Penicillamine is used to decrease cystine excretion by forming a soluble complex, cystine-D-penicillamine disulphide.<\/li>\n<li><strong>Management of lead toxicity:<\/strong> Penicillamine may be used when injecting EDTA is challenging or when long-term chelation is necessary.<\/li>\n<\/ul>\n<div class='code-block code-block-12' style='margin: 8px auto; text-align: center; display: block; clear: both;'>\n<a target=\"_blank\" href=\"https:\/\/www.vet-ebooks.com\/premium-memberships\/\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-17003\" src=\"https:\/\/www.vet-ebooks.com\/wp-content\/uploads\/2024\/10\/veterinary-books-1.jpg\" width=\"480\" height=\"98\"  alt=\"Vet Books\"\/><\/a><\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Dose of Penicillamine in Dogs and Cats<\/strong><\/h2>\n<p><strong>Dogs<\/strong>:<\/p>\n<ul>\n<li><span style=\"text-decoration: underline;\"><strong> Copper storage disease and copper-associated hepatitis<\/strong><\/span>: 10 mg\/kg p.o. q12h given on an empty stomach at least 1 hour before feeding.<\/li>\n<li><span style=\"text-decoration: underline;\"><strong>Cystinuria<\/strong><\/span>: 10\u201315 mg\/kg p.o. q12h.<\/li>\n<li><span style=\"text-decoration: underline;\"><strong>Lead poisoning<\/strong><\/span>: patients commonly receive CaEDTA before receiving penicillamine 30 minutes before feeding at 30 mg\/kg p.o. q6\u20138h for 1\u20132 weeks.<\/li>\n<li>The dose may then be reduced to 5 mg\/kg p.o. q6\u20138h if serum lead levels remain high despite the resolution of clinical signs.<\/li>\n<\/ul>\n<p><strong>Cats:<\/strong><\/p>\n<ul>\n<li><span style=\"text-decoration: underline;\"><strong>Lead poisoning<\/strong><\/span>: patients commonly receive CaEDTA before receiving penicillamine 30 minutes before feeding at 15 mg\/kg p.o. q6\u20138h for 1 week.<\/li>\n<li>The dose may then be reduced to 5 mg\/kg p.o. q6\u20138h if serum lead levels remain high despite the resolution of clinical signs.<\/li>\n<\/ul>\n<div class='code-block code-block-2' style='margin: 8px auto 8px 0; text-align: left; display: block; clear: both;'>\n <html>\n  <head>\n    <style>\n    \n \n      #calculator {\n        width: 100%;\n        margin: auto;\n      }\n      \n      @media (max-width: 600px) {\n        #calculator {\n          width: 90%;\n        }\n      }\n      \n      #calculator23 {\n        display: block;\n        margin-bottom: 8px;\n        font-size: 14px;\nfont-family: sans-serif;font-weight:600;\n      }\n      \n      #calculator24{\n        width: 100%;\n        padding: 12px 20px;\n        margin: 8px 0;\n        box-sizing: border-box;\n        border: 2px solid #ccc;\n        border-radius: 4px;\n      }\n      \n      #calculator25 {\n        width: 100%;\n    background-color: #fabd14;\n    color: white;\n    padding: 11px 18px;\n    margin: 5px 0;\n    border: none;\n    border-radius: 4px;\n    cursor: pointer;\n    font-size: 15px;\n    font-family: sans-serif;\n    font-weight: 600;\n}\n      }\n      \n      #result {\n        font-size: 18px;\n        font-weight: bold;\n      }\n    <\/style>\n  <\/head>\n  <body>\n  \n \n\n  <h2 style=\"border-bottom: 2px #fff7e6 solid;\" class=\"cd-section-title\"><span><strong>Drug Dosage Calculator<\/strong><\/span><\/h2>\n    <form id=\"calculator\">\n      <label id=\"calculator23\" for=\"weight\">Animal Weight (kg):<\/label>\n      <input type=\"text\" id=\"weight\" name=\"weight\" id=\"calculator24\">\n      <label for=\"dose\" id=\"calculator23\">Drug Dose (mg\/kg):<\/label>\n      <input type=\"text\" id=\"dose\" name=\"dose\" id=\"calculator24\">\n      <label for=\"concentration\" id=\"calculator23\">Drug Concentration (mg\/mL or mg\/tablet):<\/label>\n      <input type=\"text\" id=\"concentration\" name=\"concentration\" id=\"calculator24\">\n      <button type=\"button\" onclick=\"calculate()\" id=\"calculator25\">Calculate<\/button>\n    <\/form> \n    \n    <p style=\"\n    font-size: 13px;\n    font-weight: 600;\n    font-family: sans-serif;\n    background: #444;\n    padding: 5px;\n    border-radius: 5px;\n    color: #fff;\n\">You Should Give: <span id=\"result\"><\/span><\/p>\n\n\n    \n    <script>\n      function calculateDose(weight, dose, concentration) {\n        return (weight * dose \/ concentration).toFixed(2);\n      }\n      \n      function calculate() {\n        let weight = document.getElementById(\"weight\").value;\n        let dose = document.getElementById(\"dose\").value;\n        let concentration = document.getElementById(\"concentration\").value;\n        let result = calculateDose(weight, dose, concentration);\n        document.getElementById(\"result\").innerHTML = result + \" mL or tablet \";\n      }\n    <\/script>\n  <\/body>\n<\/html>\n<\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Side Effects of Penicillamine in Dogs and Cats<\/strong><\/h2>\n<ul>\n<li>Anorexia, vomiting, pyrexia, and nephrotic syndrome are seen in dogs.<\/li>\n<li>Serious adverse effects described in humans given penicillamine include leucopenia, thrombocytopenia, fever, lymphadenopathy, skin hypersensitivity reactions, and lupus-like reactions.<\/li>\n<li>Weekly initial monitoring, including a full blood count and urinalysis, is advised for dogs.<\/li>\n<li>Allergic reactions in humans to penicillin may have similar reactions to penicillamine, but cross-sensitivity seems to be rare.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Contraindications of Penicillamine in Dogs and Cats<\/strong><\/h2>\n<ul>\n<li>Moderate to marked renal impairment and a history of penicillamine-related blood dyscrasias.<\/li>\n<li>Penicillamine can reduce gastrointestinal absorption of dietary minerals, including<br \/>\nzinc, iron, copper and calcium and, therefore, cause deficiencies with long-term use.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Some Notes:<\/strong><\/h2>\n<ul>\n<li>The absorption of penicillamine is decreased if administered with antacids, food, or iron or zinc salts.<\/li>\n<li>An increase in the renal and haematological effects of penicillamine have been<br \/>\nrecorded in humans receiving it with cytotoxic drugs.<\/li>\n<li>Concomitant use of NSAIDs and other nephrotoxic drugs may increase the risk of<br \/>\nrenal damage.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Penicillamine In Dogs &amp; Cats: Uses, Dosage and Side Effects Overview Penicillamine is an orally administered chelating agent that binds copper, mercury and lead. It also binds to cystine. Uses of Penicillamine Management of copper storage disease in Bedlington Terriers and copper-associated hepatopathy in other susceptible breeds. Penicillamine is not effective in acute crises due [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2403,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-2378","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-antidotes"],"_links":{"self":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/2378","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/comments?post=2378"}],"version-history":[{"count":0,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/2378\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media\/2403"}],"wp:attachment":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media?parent=2378"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/categories?post=2378"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/tags?post=2378"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}