{"id":2116,"date":"2023-09-25T00:58:27","date_gmt":"2023-09-24T21:58:27","guid":{"rendered":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/?p=2116"},"modified":"2023-09-25T00:58:27","modified_gmt":"2023-09-24T21:58:27","slug":"mitoxantrone","status":"publish","type":"post","link":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/mitoxantrone\/","title":{"rendered":"Mitoxantrone"},"content":{"rendered":"

Mitoxantrone In Dogs & Cats: Uses, Dosage and Side Effects<\/strong><\/p>\n

$\"Mitoxantrone$ <\/p>\n\n

Overview<\/strong><\/h2>\n
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Antitumour antibiotic<\/strong> which inhibits topoisomerase II.<\/li>\n
It is cell cycle non-specific, but most active during the S phase.<\/li>\n<\/ul>\n
Uses of Mitoxantrone<\/strong><\/h2>\n
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Treatment of canine and feline lymphoma<\/strong>, squamous cell carcinoma<\/strong> (SCC), and transitional cell carcinoma<\/strong>.<\/li>\n<\/ul>\n
Its use has also been described in:<\/strong><\/span><\/p>\n
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Renal adenocarcinoma.<\/li>\n
Ribroid sarcoma.<\/li>\n
Anal gland adenocarcinoma.<\/li>\n
Thyroid carcinoma.<\/li>\n
Prostate carcinoma.<\/li>\n
Mammary gland adenocarcinoma.<\/li>\n
Feline injection site sarcoma.<\/li>\n
Haemangiopericytoma.<\/li>\n
Radiosensitizer in cats with oral SCC.<\/li>\n<\/ul>\n
\n $\"Vet$ <\/a><\/div>\n\n
Dose of Mitoxantrone in Dogs and Cats<\/strong><\/h2>\n
Dogs:<\/strong><\/p>\n
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All uses <\/strong><\/span>: 5\u20136 mg\/m2 i.v. once every 3 weeks (It should be diluted with up to 50 ml of 0.9% NaCl).<\/li>\n
Intrapleural\/intraperitoneal dose<\/strong><\/span>: 5 mg\/m2 \u20135.5 mg\/m2 diluted in 0.9% NaCl over a 5\u201310 min period. In one text this is diluted 1:1 in 0.9% NaCl then again in 1 ml per 4.5 kg body weight (it is advised to consult a veterinary oncology specialist before administering via this route).<\/li>\n<\/ul>\n
Cats:<\/strong><\/p>\n
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All uses<\/strong><\/span>: 5.5\u20136.5 mg\/m2 i.v. once every 3 weeks. (It should be diluted with up to 50 ml of 0.9% NaCl).<\/li>\n<\/ul>\n
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