{"id":2111,"date":"2023-09-28T00:03:07","date_gmt":"2023-09-27T21:03:07","guid":{"rendered":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/?p=2111"},"modified":"2023-09-28T00:03:07","modified_gmt":"2023-09-27T21:03:07","slug":"misoprostol","status":"publish","type":"post","link":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/misoprostol\/","title":{"rendered":"Misoprostol"},"content":{"rendered":"<p style=\"text-align: center; font-size: 24px; font-family: sans-serif;\"><strong>Misoprostol In Dogs &amp; Cats: Uses, Dosage and Side Effects<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-2249\" src=\"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/09\/Misoprostol.jpg\" alt=\"Misoprostol In Dogs &amp; Cats: Uses, Dosage and Side Effects\" width=\"679\" height=\"408\" srcset=\"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/09\/Misoprostol.jpg 800w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/09\/Misoprostol-300x180.jpg 300w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/09\/Misoprostol-768x461.jpg 768w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/09\/Misoprostol-696x418.jpg 696w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/09\/Misoprostol-700x420.jpg 700w\" sizes=\"auto, (max-width: 679px) 100vw, 679px\" \/><\/p>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Overview<\/strong><\/h2>\n<p><strong><span style=\"text-decoration: underline;\">Cytoprotection of the gastric mucosa<\/span>:<\/strong><\/p>\n<ul>\n<li>It inhibits gastric acid secretion and increases bicarbonate and mucus secretion, as well as epithelial cell turnover and mucosal blood flow.<\/li>\n<li>It prevents and facilitates the healing of gastric and duodenal ulcers, especially those associated with the use of nonsteroidal anti-inflammatory drugs.<\/li>\n<li>Some reports indicate that it may not prevent gastric haemorrhage caused by high methylprednisolone doses.<\/li>\n<li>Additionally, it may be beneficial in the treatment of canine atopy, although other treatments are likely safer.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Uses of Misoprostol<\/strong><\/h2>\n<ul>\n<li>Protection against NSAID-induced gastric ulceration.<\/li>\n<li><span style=\"text-decoration: underline;\"><strong>In humans<\/strong><\/span>, higher doses (20 \u03bcg \/kg p.o. q6\u201312h) are used to manage pre-existing NSAID-induced gastric ulceration, while doses of 2\u20135 \u03bcg\/kg p.o. q6\u20138h are used prophylactically to prevent ulceration.<\/li>\n<li>Has been used in<strong> combination with aglepristone<\/strong> to induce <strong>abortion<\/strong> in dogs and cats.<\/li>\n<\/ul>\n<div class='code-block code-block-12' style='margin: 8px auto; text-align: center; display: block; clear: both;'>\n<a target=\"_blank\" href=\"https:\/\/www.vet-ebooks.com\/premium-memberships\/\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-17003\" src=\"https:\/\/www.vet-ebooks.com\/wp-content\/uploads\/2024\/10\/veterinary-books-1.jpg\" width=\"480\" height=\"98\"  alt=\"Vet Books\"\/><\/a><\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Dose of Misoprostol in Dogs and Cats<\/strong><\/h2>\n<p><strong>Dogs:<\/strong><\/p>\n<ul>\n<li><span style=\"text-decoration: underline;\">Protection against NSAID-induced gastric ulceration<\/span>: 2\u20135 <strong>\u03bcg<\/strong> \/kg p.o. q8\u201312h.<\/li>\n<li><span style=\"text-decoration: underline;\">Atopic dermatitis<\/span>: 3\u20136<strong> \u03bcg<\/strong>\/kg p.o. q8h has been suggested.<\/li>\n<\/ul>\n<p><strong>Cats:<\/strong><\/p>\n<ul>\n<li><span style=\"text-decoration: underline;\">Protection against NSAID-induced gastric ulceration<\/span>: 5 <strong>\u03bcg<\/strong> \/kg p.o. q8h.<\/li>\n<\/ul>\n<div class='code-block code-block-2' style='margin: 8px auto 8px 0; text-align: left; display: block; clear: both;'>\n <html>\n  <head>\n    <style>\n    \n \n      #calculator {\n        width: 100%;\n        margin: auto;\n      }\n      \n      @media (max-width: 600px) {\n        #calculator {\n          width: 90%;\n        }\n      }\n      \n      #calculator23 {\n        display: block;\n        margin-bottom: 8px;\n        font-size: 14px;\nfont-family: sans-serif;font-weight:600;\n      }\n      \n      #calculator24{\n        width: 100%;\n        padding: 12px 20px;\n        margin: 8px 0;\n        box-sizing: border-box;\n        border: 2px solid #ccc;\n        border-radius: 4px;\n      }\n      \n      #calculator25 {\n        width: 100%;\n    background-color: #fabd14;\n    color: white;\n    padding: 11px 18px;\n    margin: 5px 0;\n    border: none;\n    border-radius: 4px;\n    cursor: pointer;\n    font-size: 15px;\n    font-family: sans-serif;\n    font-weight: 600;\n}\n      }\n      \n      #result {\n        font-size: 18px;\n        font-weight: bold;\n      }\n    <\/style>\n  <\/head>\n  <body>\n  \n \n\n  <h2 style=\"border-bottom: 2px #fff7e6 solid;\" class=\"cd-section-title\"><span><strong>Drug Dosage Calculator<\/strong><\/span><\/h2>\n    <form id=\"calculator\">\n      <label id=\"calculator23\" for=\"weight\">Animal Weight (kg):<\/label>\n      <input type=\"text\" id=\"weight\" name=\"weight\" id=\"calculator24\">\n      <label for=\"dose\" id=\"calculator23\">Drug Dose (mg\/kg):<\/label>\n      <input type=\"text\" id=\"dose\" name=\"dose\" id=\"calculator24\">\n      <label for=\"concentration\" id=\"calculator23\">Drug Concentration (mg\/mL or mg\/tablet):<\/label>\n      <input type=\"text\" id=\"concentration\" name=\"concentration\" id=\"calculator24\">\n      <button type=\"button\" onclick=\"calculate()\" id=\"calculator25\">Calculate<\/button>\n    <\/form> \n    \n    <p style=\"\n    font-size: 13px;\n    font-weight: 600;\n    font-family: sans-serif;\n    background: #444;\n    padding: 5px;\n    border-radius: 5px;\n    color: #fff;\n\">You Should Give: <span id=\"result\"><\/span><\/p>\n\n\n    \n    <script>\n      function calculateDose(weight, dose, concentration) {\n        return (weight * dose \/ concentration).toFixed(2);\n      }\n      \n      function calculate() {\n        let weight = document.getElementById(\"weight\").value;\n        let dose = document.getElementById(\"dose\").value;\n        let concentration = document.getElementById(\"concentration\").value;\n        let result = calculateDose(weight, dose, concentration);\n        document.getElementById(\"result\").innerHTML = result + \" mL or tablet \";\n      }\n    <\/script>\n  <\/body>\n<\/html>\n<\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Side Effects of Misoprostol in Dogs and Cats<\/strong><\/h2>\n<ul>\n<li>Diarrhoea, abdominal pain, nausea, vomiting and abortion.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Contraindications of Misoprostol in Dogs and Cats<\/strong><\/h2>\n<ul>\n<li>Do not use in pregnant animals.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Some Notes:<\/strong><\/h2>\n<ul>\n<li>Give with food.<\/li>\n<li>Combinations with diclofenac are available for humans, but are not suitable for small animals because of different NSAID pharmacokinetics.<\/li>\n<li>Use of misoprostol with gentamicin may exacerbate renal dysfunction.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Misoprostol In Dogs &amp; Cats: Uses, Dosage and Side Effects Overview Cytoprotection of the gastric mucosa: It inhibits gastric acid secretion and increases bicarbonate and mucus secretion, as well as epithelial cell turnover and mucosal blood flow. It prevents and facilitates the healing of gastric and duodenal ulcers, especially those associated with the use of [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2249,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[21],"tags":[],"class_list":["post-2111","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-gastrointestinal"],"_links":{"self":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/2111","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/comments?post=2111"}],"version-history":[{"count":0,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/2111\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media\/2249"}],"wp:attachment":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media?parent=2111"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/categories?post=2111"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/tags?post=2111"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}