{"id":1913,"date":"2023-08-16T14:12:51","date_gmt":"2023-08-16T11:12:51","guid":{"rendered":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/?p=1913"},"modified":"2023-08-12T17:19:35","modified_gmt":"2023-08-12T14:19:35","slug":"lomustine-ccnu","status":"publish","type":"post","link":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/lomustine-ccnu\/","title":{"rendered":"Lomustine (CCNU)"},"content":{"rendered":"

Lomustine (CCNU) In Dogs & Cats: Uses, Dosage and Side Effects<\/strong><\/p>\n

$\"Lomustine$ <\/p>\n\n

Overview<\/strong><\/h2>\n
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Interferes with the synthesis and function of DNA, RNA and proteins.<\/li>\n
Antitumour activity correlates best with formation of interstrand cross-linking of DNA.<\/li>\n
Lomustine is highly lipid-soluble, allowing rapid transport across the blood\u2013brain barrier.<\/li>\n<\/ul>\n
Uses of Lomustine (CCNU)<\/strong><\/h2>\n
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Reported to have some efficacy in the treatment of brain tumours<\/strong>, mast cell tumours<\/strong>, refractory lymphoma<\/strong>, histiocytic sarcoma<\/strong> and epitheliotrophic lymphoma<\/strong>.<\/li>\n
Component of the modified CHOP protocol for treatment of T-cell lymphoma<\/strong>.<\/li>\n<\/ul>\n
\n $\"Vet$ <\/a><\/div>\n\n
Dose of Lomustine (CCNU) in Dogs and Cats<\/strong><\/h2>\n
Dogs: <\/strong><\/p>\n
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All uses:<\/strong> <\/span>60\u201380 mg\/m2 p.o. q3\u20134wk.<\/li>\n<\/ul>\n
Cats: <\/strong><\/p>\n
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All uses:<\/strong><\/span> A dose of 30\u201360 mg\/m2 p.o. q4\u20136wk has been suggested but is not well established.<\/li>\n
If using this drug in the cat<\/strong>, specialist advice should be sought, as dosing intervals may need to be increased.<\/li>\n<\/ul>\n
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