{"id":1744,"date":"2023-06-30T15:56:08","date_gmt":"2023-06-30T12:56:08","guid":{"rendered":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/?p=1744"},"modified":"2023-06-30T15:56:08","modified_gmt":"2023-06-30T12:56:08","slug":"itraconazole","status":"publish","type":"post","link":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/itraconazole\/","title":{"rendered":"Itraconazole"},"content":{"rendered":"<p style=\"text-align: center; font-size: 24px; font-family: sans-serif;\"><strong>Itraconazole In Dogs &amp; Cats: Uses, Dosage and Side Effects<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1758 size-full\" src=\"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/06\/Itraconazole.jpg\" alt=\"Itraconazole In Dogs &amp; Cats: Uses, Dosage and Side Effects\" width=\"800\" height=\"480\" srcset=\"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/06\/Itraconazole.jpg 800w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/06\/Itraconazole-300x180.jpg 300w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/06\/Itraconazole-768x461.jpg 768w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/06\/Itraconazole-696x418.jpg 696w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/06\/Itraconazole-700x420.jpg 700w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/p>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Overview<\/strong><\/h2>\n<ul>\n<li><strong>Triazole antifungal agent<\/strong> that inhibits the cytochrome systems involved in the synthesis of ergosterol in fungal cell membranes, resulting in an increase in cell wall permeability and cellular content leakage.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Uses of Itraconazole<\/strong><\/h2>\n<ul>\n<li>Aspergillosis, candidiasis, blastomycosis, coccidioidomycosis, cryptococcosis, sporotrichosis, histoplasmosis, dermatophytosis, and Malassezia treatment.<\/li>\n<li>Itraconazole is approved as an <strong>oral solution<\/strong> for the treatment of <strong>Microsporum canis<\/strong> <strong>dermatophytosis in cats<\/strong>, and it has been used effectively to treat <strong>ringworm<\/strong> in Persian cats without clipping.<\/li>\n<\/ul>\n<div class='code-block code-block-12' style='margin: 8px auto; text-align: center; display: block; clear: both;'>\n<a target=\"_blank\" href=\"https:\/\/www.vet-ebooks.com\/premium-memberships\/\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-17003\" src=\"https:\/\/www.vet-ebooks.com\/wp-content\/uploads\/2024\/10\/veterinary-books-1.jpg\" width=\"480\" height=\"98\"  alt=\"Vet Books\"\/><\/a><\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Dose of Itraconazole in Dogs and Cats<\/strong><\/h2>\n<p><strong>Dogs, Cats:<\/strong><\/p>\n<ul>\n<li><span style=\"text-decoration: underline;\"><strong>General use:<\/strong><\/span> 5 mg\/kg p.o. q24h. 4\u201320 weeks of treatment may be needed, dependent upon culture results.<\/li>\n<li><span style=\"text-decoration: underline;\"><strong>Pulse dosing<\/strong><\/span> (7 days on, 7 days off repeated x3) described for dermatophytosis in cats.<\/li>\n<\/ul>\n<div class='code-block code-block-2' style='margin: 8px auto 8px 0; text-align: left; display: block; clear: both;'>\n <html>\n  <head>\n    <style>\n    \n \n      #calculator {\n        width: 100%;\n        margin: auto;\n      }\n      \n      @media (max-width: 600px) {\n        #calculator {\n          width: 90%;\n        }\n      }\n      \n      #calculator23 {\n        display: block;\n        margin-bottom: 8px;\n        font-size: 14px;\nfont-family: sans-serif;font-weight:600;\n      }\n      \n      #calculator24{\n        width: 100%;\n        padding: 12px 20px;\n        margin: 8px 0;\n        box-sizing: border-box;\n        border: 2px solid #ccc;\n        border-radius: 4px;\n      }\n      \n      #calculator25 {\n        width: 100%;\n    background-color: #fabd14;\n    color: white;\n    padding: 11px 18px;\n    margin: 5px 0;\n    border: none;\n    border-radius: 4px;\n    cursor: pointer;\n    font-size: 15px;\n    font-family: sans-serif;\n    font-weight: 600;\n}\n      }\n      \n      #result {\n        font-size: 18px;\n        font-weight: bold;\n      }\n    <\/style>\n  <\/head>\n  <body>\n  \n \n\n  <h2 style=\"border-bottom: 2px #fff7e6 solid;\" class=\"cd-section-title\"><span><strong>Drug Dosage Calculator<\/strong><\/span><\/h2>\n    <form id=\"calculator\">\n      <label id=\"calculator23\" for=\"weight\">Animal Weight (kg):<\/label>\n      <input type=\"text\" id=\"weight\" name=\"weight\" id=\"calculator24\">\n      <label for=\"dose\" id=\"calculator23\">Drug Dose (mg\/kg):<\/label>\n      <input type=\"text\" id=\"dose\" name=\"dose\" id=\"calculator24\">\n      <label for=\"concentration\" id=\"calculator23\">Drug Concentration (mg\/mL or mg\/tablet):<\/label>\n      <input type=\"text\" id=\"concentration\" name=\"concentration\" id=\"calculator24\">\n      <button type=\"button\" onclick=\"calculate()\" id=\"calculator25\">Calculate<\/button>\n    <\/form> \n    \n    <p style=\"\n    font-size: 13px;\n    font-weight: 600;\n    font-family: sans-serif;\n    background: #444;\n    padding: 5px;\n    border-radius: 5px;\n    color: #fff;\n\">You Should Give: <span id=\"result\"><\/span><\/p>\n\n\n    \n    <script>\n      function calculateDose(weight, dose, concentration) {\n        return (weight * dose \/ concentration).toFixed(2);\n      }\n      \n      function calculate() {\n        let weight = document.getElementById(\"weight\").value;\n        let dose = document.getElementById(\"dose\").value;\n        let concentration = document.getElementById(\"concentration\").value;\n        let result = calculateDose(weight, dose, concentration);\n        document.getElementById(\"result\").innerHTML = result + \" mL or tablet \";\n      }\n    <\/script>\n  <\/body>\n<\/html>\n<\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Side Effects of Itraconazole in Dogs and Cats<\/strong><\/h2>\n<ul>\n<li>Vomiting, diarrhoea, loss of appetite, excessive salivation, sadness and apathy, abdominal pain, hepatic toxicosis, ulcerative dermatitis, limb oedema, and serious skin drug eruptions have all been recorded.<\/li>\n<li>It seems likely that the dose will affect how well the adrenal glands work (like what has been said about ketoconazole).<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Contraindications of Itraconazole in Dogs and Cats<\/strong><\/h2>\n<ul>\n<li>Pregnancy.<\/li>\n<li>Avoid use if liver disease is present<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Some Notes:<\/strong><\/h2>\n<ul>\n<li>Antifungal imidazoles and triazoles inhibit the metabolism of antihistamines (especially terfenadine), oral hypoglycemics, antiepileptics, cisapride, ciclosporin, and glucocorticoids in humans.<\/li>\n<li>It is known that itraconazole enhances the bioavailability of ciclosporin in cats, despite the fact that this effect has not been as thoroughly studied in veterinary species.<\/li>\n<li>Antacids, omeprazole, H2 antagonists, and adsorbents may inhibit itraconazole absorption.<\/li>\n<li>Itraconazole may increase plasma concentrations of digoxin, benzodiazepines, glucocorticoids, and vincristine.<\/li>\n<li>In the data leaflet, concurrent administration with cefovecin or tolfenamic acid in cats is discouraged.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Itraconazole In Dogs &amp; Cats: Uses, Dosage and Side Effects Overview Triazole antifungal agent that inhibits the cytochrome systems involved in the synthesis of ergosterol in fungal cell membranes, resulting in an increase in cell wall permeability and cellular content leakage. Uses of Itraconazole Aspergillosis, candidiasis, blastomycosis, coccidioidomycosis, cryptococcosis, sporotrichosis, histoplasmosis, dermatophytosis, and Malassezia treatment. [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":1758,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[37],"tags":[],"class_list":["post-1744","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-antifungal"],"_links":{"self":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/1744","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/comments?post=1744"}],"version-history":[{"count":0,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/1744\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media\/1758"}],"wp:attachment":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media?parent=1744"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/categories?post=1744"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/tags?post=1744"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}