{"id":1725,"date":"2023-07-24T23:24:48","date_gmt":"2023-07-24T20:24:48","guid":{"rendered":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/?p=1725"},"modified":"2023-07-26T16:47:31","modified_gmt":"2023-07-26T13:47:31","slug":"imepitoin","status":"publish","type":"post","link":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/imepitoin\/","title":{"rendered":"Imepitoin"},"content":{"rendered":"<p style=\"text-align: center; font-size: 24px; font-family: sans-serif;\"><strong>Imepitoin: Uses, Dosage and Side Effects<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1846 \" src=\"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/06\/Imepitoin.jpg\" alt=\"Imepitoin: Uses, Dosage and Side Effects\" width=\"661\" height=\"397\" srcset=\"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/06\/Imepitoin.jpg 800w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/06\/Imepitoin-300x180.jpg 300w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/06\/Imepitoin-768x461.jpg 768w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/06\/Imepitoin-696x418.jpg 696w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/06\/Imepitoin-700x420.jpg 700w\" sizes=\"auto, (max-width: 661px) 100vw, 661px\" \/><\/p>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Overview<\/strong><\/h2>\n<ul>\n<li>Imepitoin <strong>prevents seizures<\/strong> by potentiating the inhibitory actions of GABAA receptors on neurons.<\/li>\n<li>Imepitoin also possesses a mild calcium-channel blocking activity, which may help explain its <strong>anticonvulsant<\/strong> characteristics.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Uses of Imepitoin<\/strong><\/h2>\n<ul>\n<li>Imepitoin and phenobarbital are the first-line drugs used to treat<strong> epileptic seizures in dogs with idiopathic epilepsy.<\/strong><\/li>\n<li>Imepitoin may be used in conjunction with a behaviour modification strategy <strong>to control anxiety in dogs<\/strong> in reaction to both social stimuli (e.g. crowds, strangers) and non-social stimuli (e.g. noises, unfamiliar items, new locations).<\/li>\n<li>Use with caution in dogs <strong>demonstrating aggressive behaviour<\/strong>, and risk management should be implemented.<\/li>\n<\/ul>\n<div class='code-block code-block-12' style='margin: 8px auto; text-align: center; display: block; clear: both;'>\n<a target=\"_blank\" href=\"https:\/\/www.vet-ebooks.com\/premium-memberships\/\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-17003\" src=\"https:\/\/www.vet-ebooks.com\/wp-content\/uploads\/2024\/10\/veterinary-books-1.jpg\" width=\"480\" height=\"98\"  alt=\"Vet Books\"\/><\/a><\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Dose of Imepitoin in Dogs and Cats<\/strong><\/h2>\n<p><strong>Dogs:<\/strong><\/p>\n<ul>\n<li>10\u201330 mg\/kg p.o. q12h.<\/li>\n<li>Doses towards the higher end of the range appear to be more effective.<\/li>\n<li><span style=\"text-decoration: underline;\"><strong>For the control of anxiety:<\/strong><\/span> an initial dose of 10 mg\/kg p.o. q12h is recommended, but the dose may be titrated up to 30 mg\/kg p.o. q12h or down to 5 mg\/kg p.o. q12h as necessary, dependent on the initial response.<\/li>\n<\/ul>\n<p><strong>Cats:<\/strong><\/p>\n<ul>\n<li>Imepitoin is well tolerated in healthy cats at similar doses to dogs (10\u201330 mg\/kg p.o. q12h) but its efficacy to control seizures or anxiety remains unproven.<\/li>\n<\/ul>\n<div class='code-block code-block-2' style='margin: 8px auto 8px 0; text-align: left; display: block; clear: both;'>\n <html>\n  <head>\n    <style>\n    \n \n      #calculator {\n        width: 100%;\n        margin: auto;\n      }\n      \n      @media (max-width: 600px) {\n        #calculator {\n          width: 90%;\n        }\n      }\n      \n      #calculator23 {\n        display: block;\n        margin-bottom: 8px;\n        font-size: 14px;\nfont-family: sans-serif;font-weight:600;\n      }\n      \n      #calculator24{\n        width: 100%;\n        padding: 12px 20px;\n        margin: 8px 0;\n        box-sizing: border-box;\n        border: 2px solid #ccc;\n        border-radius: 4px;\n      }\n      \n      #calculator25 {\n        width: 100%;\n    background-color: #fabd14;\n    color: white;\n    padding: 11px 18px;\n    margin: 5px 0;\n    border: none;\n    border-radius: 4px;\n    cursor: pointer;\n    font-size: 15px;\n    font-family: sans-serif;\n    font-weight: 600;\n}\n      }\n      \n      #result {\n        font-size: 18px;\n        font-weight: bold;\n      }\n    <\/style>\n  <\/head>\n  <body>\n  \n \n\n  <h2 style=\"border-bottom: 2px #fff7e6 solid;\" class=\"cd-section-title\"><span><strong>Drug Dosage Calculator<\/strong><\/span><\/h2>\n    <form id=\"calculator\">\n      <label id=\"calculator23\" for=\"weight\">Animal Weight (kg):<\/label>\n      <input type=\"text\" id=\"weight\" name=\"weight\" id=\"calculator24\">\n      <label for=\"dose\" id=\"calculator23\">Drug Dose (mg\/kg):<\/label>\n      <input type=\"text\" id=\"dose\" name=\"dose\" id=\"calculator24\">\n      <label for=\"concentration\" id=\"calculator23\">Drug Concentration (mg\/mL or mg\/tablet):<\/label>\n      <input type=\"text\" id=\"concentration\" name=\"concentration\" id=\"calculator24\">\n      <button type=\"button\" onclick=\"calculate()\" id=\"calculator25\">Calculate<\/button>\n    <\/form> \n    \n    <p style=\"\n    font-size: 13px;\n    font-weight: 600;\n    font-family: sans-serif;\n    background: #444;\n    padding: 5px;\n    border-radius: 5px;\n    color: #fff;\n\">You Should Give: <span id=\"result\"><\/span><\/p>\n\n\n    \n    <script>\n      function calculateDose(weight, dose, concentration) {\n        return (weight * dose \/ concentration).toFixed(2);\n      }\n      \n      function calculate() {\n        let weight = document.getElementById(\"weight\").value;\n        let dose = document.getElementById(\"dose\").value;\n        let concentration = document.getElementById(\"concentration\").value;\n        let result = calculateDose(weight, dose, concentration);\n        document.getElementById(\"result\").innerHTML = result + \" mL or tablet \";\n      }\n    <\/script>\n  <\/body>\n<\/html>\n<\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Side Effects of Imepitoin in Dogs and Cats<\/strong><\/h2>\n<ul>\n<li><strong>Sedation<\/strong> is the most often reported side effect, particularly in dogs on higher dosages or already on phenobarbital therapy.<\/li>\n<li>An <strong>adverse cutaneous reaction<\/strong> has been documented.<\/li>\n<li>Other side effects include polyphagia, hyperactivity, polyuria, polydipsia, somnolence, hypersalivation, emesis, ataxia, apathy, diarrhoea, prolapsed nictitating membrane, impaired sight, and a paradoxical increase in sound sensitivity.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Contraindications of Imepitoin in Dogs and Cats<\/strong><\/h2>\n<ul>\n<li>The medication should not be used with severely impaired liver, kidney and heart function.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Some Notes:<\/strong><\/h2>\n<ul>\n<li>Imepitoin has a faster onset of action than phenobarbital (a steady state is not required), does not require serum concentration determination, and has a less severe adverse effect profile; however, phenobarbital is less expensive and more efficacious.<\/li>\n<li>Imepitoin is well tolerated in healthy cats at levels comparable to dogs, however, its efficacy in controlling seizures has yet to be established.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Imepitoin: Uses, Dosage and Side Effects Overview Imepitoin prevents seizures by potentiating the inhibitory actions of GABAA receptors on neurons. Imepitoin also possesses a mild calcium-channel blocking activity, which may help explain its anticonvulsant characteristics. Uses of Imepitoin Imepitoin and phenobarbital are the first-line drugs used to treat epileptic seizures in dogs with idiopathic epilepsy. [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":1846,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[73,19],"tags":[],"class_list":["post-1725","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-anticonvulsants","category-behavior-modifiers"],"_links":{"self":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/1725","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/comments?post=1725"}],"version-history":[{"count":0,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/1725\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media\/1846"}],"wp:attachment":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media?parent=1725"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/categories?post=1725"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/tags?post=1725"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}