{"id":1707,"date":"2023-07-23T23:11:35","date_gmt":"2023-07-23T20:11:35","guid":{"rendered":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/?p=1707"},"modified":"2023-07-21T23:15:31","modified_gmt":"2023-07-21T20:15:31","slug":"hydralazine","status":"publish","type":"post","link":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/hydralazine\/","title":{"rendered":"Hydralazine"},"content":{"rendered":"<p style=\"text-align: center; font-size: 24px; font-family: sans-serif;\"><strong>Hydralazine: Uses, Dosage and Side Effects<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-1833 aligncenter\" src=\"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/06\/Hydralazine.jpg\" alt=\"Hydralazine: Uses, Dosage and Side Effects\" width=\"673\" height=\"404\" srcset=\"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/06\/Hydralazine.jpg 800w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/06\/Hydralazine-300x180.jpg 300w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/06\/Hydralazine-768x461.jpg 768w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/06\/Hydralazine-696x418.jpg 696w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/06\/Hydralazine-700x420.jpg 700w\" sizes=\"auto, (max-width: 673px) 100vw, 673px\" \/><\/p>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Overview<\/strong><\/h2>\n<ul>\n<li>Hydralazine primarily acts on arteriolar smooth muscle, inducing vasodilation; it can reduce systemic vascular resistance to around 50% of the baseline value.<\/li>\n<li>Hydralazine reduces afterload while increasing heart rate, stroke volume, and cardiac output.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Uses of Hydralazine<\/strong><\/h2>\n<ul>\n<li><strong>Afterload reducer<\/strong> as adjunctive therapy for <strong>canine congestive heart failure<\/strong> due to <strong>severe or refractory mitral insufficiency<\/strong>.<\/li>\n<li>.It may be used to treat <strong>systemic hypertension<\/strong> (though not as a first-line medication).<\/li>\n<\/ul>\n<div class='code-block code-block-12' style='margin: 8px auto; text-align: center; display: block; clear: both;'>\n<a target=\"_blank\" href=\"https:\/\/www.vet-ebooks.com\/premium-memberships\/\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-17003\" src=\"https:\/\/www.vet-ebooks.com\/wp-content\/uploads\/2024\/10\/veterinary-books-1.jpg\" width=\"480\" height=\"98\"  alt=\"Vet Books\"\/><\/a><\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Dose of Hydralazine in Dogs and Cats<\/strong><\/h2>\n<p><strong>Dogs:<\/strong><\/p>\n<ul>\n<li>0.5\u20133 mg\/kg p.o. q8\u201312h. Start at low dose (0.5\u20131 mg\/kg q12h).<\/li>\n<li>Monitor blood pressure regularly and increase to 2 mg\/kg or even 3 mg\/kg q12h if necessary.<\/li>\n<\/ul>\n<p><strong>Cats:<\/strong><\/p>\n<ul>\n<li>2.5\u201310 mg\/cat p.o. q12h.<\/li>\n<li>Start at low dose and titrate upwards cautiously as above if necessary.<\/li>\n<\/ul>\n<div class='code-block code-block-2' style='margin: 8px auto 8px 0; text-align: left; display: block; clear: both;'>\n <html>\n  <head>\n    <style>\n    \n \n      #calculator {\n        width: 100%;\n        margin: auto;\n      }\n      \n      @media (max-width: 600px) {\n        #calculator {\n          width: 90%;\n        }\n      }\n      \n      #calculator23 {\n        display: block;\n        margin-bottom: 8px;\n        font-size: 14px;\nfont-family: sans-serif;font-weight:600;\n      }\n      \n      #calculator24{\n        width: 100%;\n        padding: 12px 20px;\n        margin: 8px 0;\n        box-sizing: border-box;\n        border: 2px solid #ccc;\n        border-radius: 4px;\n      }\n      \n      #calculator25 {\n        width: 100%;\n    background-color: #fabd14;\n    color: white;\n    padding: 11px 18px;\n    margin: 5px 0;\n    border: none;\n    border-radius: 4px;\n    cursor: pointer;\n    font-size: 15px;\n    font-family: sans-serif;\n    font-weight: 600;\n}\n      }\n      \n      #result {\n        font-size: 18px;\n        font-weight: bold;\n      }\n    <\/style>\n  <\/head>\n  <body>\n  \n \n\n  <h2 style=\"border-bottom: 2px #fff7e6 solid;\" class=\"cd-section-title\"><span><strong>Drug Dosage Calculator<\/strong><\/span><\/h2>\n    <form id=\"calculator\">\n      <label id=\"calculator23\" for=\"weight\">Animal Weight (kg):<\/label>\n      <input type=\"text\" id=\"weight\" name=\"weight\" id=\"calculator24\">\n      <label for=\"dose\" id=\"calculator23\">Drug Dose (mg\/kg):<\/label>\n      <input type=\"text\" id=\"dose\" name=\"dose\" id=\"calculator24\">\n      <label for=\"concentration\" id=\"calculator23\">Drug Concentration (mg\/mL or mg\/tablet):<\/label>\n      <input type=\"text\" id=\"concentration\" name=\"concentration\" id=\"calculator24\">\n      <button type=\"button\" onclick=\"calculate()\" id=\"calculator25\">Calculate<\/button>\n    <\/form> \n    \n    <p style=\"\n    font-size: 13px;\n    font-weight: 600;\n    font-family: sans-serif;\n    background: #444;\n    padding: 5px;\n    border-radius: 5px;\n    color: #fff;\n\">You Should Give: <span id=\"result\"><\/span><\/p>\n\n\n    \n    <script>\n      function calculateDose(weight, dose, concentration) {\n        return (weight * dose \/ concentration).toFixed(2);\n      }\n      \n      function calculate() {\n        let weight = document.getElementById(\"weight\").value;\n        let dose = document.getElementById(\"dose\").value;\n        let concentration = document.getElementById(\"concentration\").value;\n        let result = calculateDose(weight, dose, concentration);\n        document.getElementById(\"result\").innerHTML = result + \" mL or tablet \";\n      }\n    <\/script>\n  <\/body>\n<\/html>\n<\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Side Effects of Hydralazine in Dogs and Cats<\/strong><\/h2>\n<ul>\n<li>Reflex tachycardia.<\/li>\n<li>severe hypotension<\/li>\n<li>Anorexia and vomiting (commonly seen in cats).<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Contraindications of Hydralazine in Dogs and Cats<\/strong><\/h2>\n<ul>\n<li>Hypovolaemia.<\/li>\n<li>Hypotension.<\/li>\n<li>Renal impairment.<\/li>\n<li>Cerebral bleeding<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Some Notes:<\/strong><\/h2>\n<ul>\n<li>Hospitalization with frequent monitoring of blood pressure is advised during its use.<\/li>\n<li>As hydralazine may cause sodium and water retention, concomitant use of diuretic therapy is often necessary.<\/li>\n<li>Give with food if possible.<\/li>\n<li>ACE inhibitors (e.g., enalapril, benazepril), anaesthetics, beta-blockers (e.g., propranolol), calcium-channel blockers (e.g., diltiazem, verapamil), corticosteroids, diuretics, and NSAIDs can increase hydralazine&#8217;s hypotensive effects.<\/li>\n<li>Tachycardia can be caused by sympathomimetics such as phenylpropanolamine.<\/li>\n<li>Adrenaline&#8217;s pressor reaction may be diminished.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Hydralazine: Uses, Dosage and Side Effects Overview Hydralazine primarily acts on arteriolar smooth muscle, inducing vasodilation; it can reduce systemic vascular resistance to around 50% of the baseline value. Hydralazine reduces afterload while increasing heart rate, stroke volume, and cardiac output. Uses of Hydralazine Afterload reducer as adjunctive therapy for canine congestive heart failure due [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":1833,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-1707","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cardiovascular"],"_links":{"self":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/1707","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/comments?post=1707"}],"version-history":[{"count":0,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/1707\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media\/1833"}],"wp:attachment":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media?parent=1707"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/categories?post=1707"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/tags?post=1707"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}