{"id":1701,"date":"2023-07-21T23:22:44","date_gmt":"2023-07-21T20:22:44","guid":{"rendered":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/?p=1701"},"modified":"2023-07-21T23:22:55","modified_gmt":"2023-07-21T20:22:55","slug":"heparin-dalteparin-enoxaparin","status":"publish","type":"post","link":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/heparin-dalteparin-enoxaparin\/","title":{"rendered":"Heparin (Dalteparin, Enoxaparin)"},"content":{"rendered":"<p style=\"text-align: center; font-size: 24px; font-family: sans-serif;\"><strong>Heparin (low molecular weight)<br \/>\n(Dalteparin, Enoxaparin): Uses, Dosage and Side Effects<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-1838\" src=\"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/06\/Heparin-Dalteparin-Enoxaparin.jpg\" alt=\"Heparin (low molecular weight) (Dalteparin, Enoxaparin): Uses, Dosage and Side Effects\" width=\"666\" height=\"400\" srcset=\"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/06\/Heparin-Dalteparin-Enoxaparin.jpg 800w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/06\/Heparin-Dalteparin-Enoxaparin-300x180.jpg 300w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/06\/Heparin-Dalteparin-Enoxaparin-768x461.jpg 768w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/06\/Heparin-Dalteparin-Enoxaparin-696x418.jpg 696w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/06\/Heparin-Dalteparin-Enoxaparin-700x420.jpg 700w\" sizes=\"auto, (max-width: 666px) 100vw, 666px\" \/><\/p>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Overview<\/strong><\/h2>\n<ul>\n<li><strong>Anticoagulant<\/strong> low molecular weight heparin (LMWH) suppresses Factor Xa and thrombin.<\/li>\n<li>When compared to <strong>unfractionated heparin (UFH)<\/strong>, LMWH has lower anti-IIa activity relative to anti-Xa activity (anti-Xa to anti-IIa ratio is 2-4:1 vs. UFH 1:1).<\/li>\n<li>At therapeutic levels, LMWH <strong>has little influence on aPTT.<\/strong><\/li>\n<li><strong>Anti-Xa activity<\/strong> is used to monitor LMWH therapeutically.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Uses of Heparin (low molecular weight)<br \/>\n(Dalteparin, Enoxaparin)<\/strong><\/h2>\n<ul>\n<li>Treatment of<strong> thromboembolic complications<\/strong> and <strong>hypercoagulable syndromes<\/strong>, such as pulmonary thromboembolism and immune-mediated hemolytic anaemia (IMHA).<\/li>\n<li><strong>Humans<\/strong> are also treated with LMWH for <strong>myocardial infarction<\/strong>, <strong>atrial fibrillation<\/strong>, <strong>deep vein thrombosis<\/strong>, and <strong>pulmonary thromboembolism.<\/strong><\/li>\n<li>Its <strong>use in DIC is controversial<\/strong> because controlled clinical trials on humans have failed to demonstrate any beneficial effects.<\/li>\n<li>No longer is LMWH utilised to prevent DIC.<\/li>\n<\/ul>\n<div class='code-block code-block-12' style='margin: 8px auto; text-align: center; display: block; clear: both;'>\n<a target=\"_blank\" href=\"https:\/\/www.vet-ebooks.com\/premium-memberships\/\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-17003\" src=\"https:\/\/www.vet-ebooks.com\/wp-content\/uploads\/2024\/10\/veterinary-books-1.jpg\" width=\"480\" height=\"98\"  alt=\"Vet Books\"\/><\/a><\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Dose of Heparin (low molecular weight)<br \/>\n(Dalteparin, Enoxaparin) in Dogs and Cats<\/strong><\/h2>\n<p><strong>Dogs:<\/strong><br \/>\n\u2022 100\u2013175 IU\/kg s.c. q8h (Dalteparin).<br \/>\n\u2022 0.08 mg\/kg s.c. q6h (Enoxaparin).<\/p>\n<p><strong>Cats:<\/strong><br \/>\n\u2022 75 IU\/kg s.c. q6h (Dalteparin).<br \/>\n\u2022 0.75\u20131 mg mg\/kg s.c. q6\u201312h (Enoxaparin).<\/p>\n<p><strong>Dogs, Cats:<\/strong><\/p>\n<ul>\n<li>Anticoagulation: 80\u2013150 IU\/kg s.c. q4\u20138h.<\/li>\n<\/ul>\n<div class='code-block code-block-2' style='margin: 8px auto 8px 0; text-align: left; display: block; clear: both;'>\n <html>\n  <head>\n    <style>\n    \n \n      #calculator {\n        width: 100%;\n        margin: auto;\n      }\n      \n      @media (max-width: 600px) {\n        #calculator {\n          width: 90%;\n        }\n      }\n      \n      #calculator23 {\n        display: block;\n        margin-bottom: 8px;\n        font-size: 14px;\nfont-family: sans-serif;font-weight:600;\n      }\n      \n      #calculator24{\n        width: 100%;\n        padding: 12px 20px;\n        margin: 8px 0;\n        box-sizing: border-box;\n        border: 2px solid #ccc;\n        border-radius: 4px;\n      }\n      \n      #calculator25 {\n        width: 100%;\n    background-color: #fabd14;\n    color: white;\n    padding: 11px 18px;\n    margin: 5px 0;\n    border: none;\n    border-radius: 4px;\n    cursor: pointer;\n    font-size: 15px;\n    font-family: sans-serif;\n    font-weight: 600;\n}\n      }\n      \n      #result {\n        font-size: 18px;\n        font-weight: bold;\n      }\n    <\/style>\n  <\/head>\n  <body>\n  \n \n\n  <h2 style=\"border-bottom: 2px #fff7e6 solid;\" class=\"cd-section-title\"><span><strong>Drug Dosage Calculator<\/strong><\/span><\/h2>\n    <form id=\"calculator\">\n      <label id=\"calculator23\" for=\"weight\">Animal Weight (kg):<\/label>\n      <input type=\"text\" id=\"weight\" name=\"weight\" id=\"calculator24\">\n      <label for=\"dose\" id=\"calculator23\">Drug Dose (mg\/kg):<\/label>\n      <input type=\"text\" id=\"dose\" name=\"dose\" id=\"calculator24\">\n      <label for=\"concentration\" id=\"calculator23\">Drug Concentration (mg\/mL or mg\/tablet):<\/label>\n      <input type=\"text\" id=\"concentration\" name=\"concentration\" id=\"calculator24\">\n      <button type=\"button\" onclick=\"calculate()\" id=\"calculator25\">Calculate<\/button>\n    <\/form> \n    \n    <p style=\"\n    font-size: 13px;\n    font-weight: 600;\n    font-family: sans-serif;\n    background: #444;\n    padding: 5px;\n    border-radius: 5px;\n    color: #fff;\n\">You Should Give: <span id=\"result\"><\/span><\/p>\n\n\n    \n    <script>\n      function calculateDose(weight, dose, concentration) {\n        return (weight * dose \/ concentration).toFixed(2);\n      }\n      \n      function calculate() {\n        let weight = document.getElementById(\"weight\").value;\n        let dose = document.getElementById(\"dose\").value;\n        let concentration = document.getElementById(\"concentration\").value;\n        let result = calculateDose(weight, dose, concentration);\n        document.getElementById(\"result\").innerHTML = result + \" mL or tablet \";\n      }\n    <\/script>\n  <\/body>\n<\/html>\n<\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Side Effects of Heparin (low molecular weight)<br \/>\n(Dalteparin, Enoxaparin) in Dogs and Cats<\/strong><\/h2>\n<ul>\n<li><strong>Protamine<\/strong> can be used as an <strong>antidote<\/strong> in the event of an <strong>overdose<\/strong>.<\/li>\n<li>Heparin <strong>should not<\/strong> be given<strong> intravenously<\/strong> since it can cause haematoma formation.<\/li>\n<li>Its usage in <strong>DIC<\/strong> may <strong>exacerbate bleeding<\/strong>, particularly if the patient is thrombocytopenic.<\/li>\n<li>In humans, heparin-induced thrombocytopenia syndrome is a major concern, although it has not been observed in dogs or cats.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Contraindications of Heparin (low molecular weight)<br \/>\n(Dalteparin, Enoxaparin) in Dogs and Cats<\/strong><\/h2>\n<ul>\n<li>Bleeding disorders or severe renal dysfunction<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Some Notes:<\/strong><\/h2>\n<ul>\n<li>Use with caution when used with other medications that can cause coagulation abnormalities (e.g., aspirin, NSAIDs).<\/li>\n<li>ACTH, corticosteroids, and insulin may be inhibited by heparin.<\/li>\n<li>Heparin may raise diazepam levels in the blood.<\/li>\n<li>Heparin&#8217;s effects may be mitigated in part by antihistamines, digoxin, and tetracyclines.<\/li>\n<li>Other medications should not be mixed in the same syringe as heparin.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Heparin (low molecular weight) (Dalteparin, Enoxaparin): Uses, Dosage and Side Effects Overview Anticoagulant low molecular weight heparin (LMWH) suppresses Factor Xa and thrombin. When compared to unfractionated heparin (UFH), LMWH has lower anti-IIa activity relative to anti-Xa activity (anti-Xa to anti-IIa ratio is 2-4:1 vs. UFH 1:1). At therapeutic levels, LMWH has little influence on [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":1838,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-1701","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-anticoagulants"],"_links":{"self":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/1701","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/comments?post=1701"}],"version-history":[{"count":0,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/1701\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media\/1838"}],"wp:attachment":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media?parent=1701"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/categories?post=1701"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/tags?post=1701"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}