{"id":163,"date":"2023-01-19T19:18:10","date_gmt":"2023-01-19T17:18:10","guid":{"rendered":"https:\/\/www.vetdrugslist.com\/?p=163"},"modified":"2025-05-16T23:44:07","modified_gmt":"2025-05-16T20:44:07","slug":"amantadine-dose","status":"publish","type":"post","link":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/amantadine-dose\/","title":{"rendered":"Amantadine"},"content":{"rendered":"<p style=\"text-align: center; font-size: 24px; font-family: sans-serif;\"><strong>Amantadine for Dogs, Cats and Horses: Dosage, Uses, and Side Effects Guide<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-114 aligncenter\" src=\"https:\/\/www.vet-ebooks.com\/wp-content\/uploads\/2024\/11\/amantadine-dosage-uses-and-side-effects.jpg\" alt=\"Amantadine for Dogs, Cats and Horses: Dosage, Uses, and Side Effects Guide\" width=\"578\" height=\"347\" \/><\/p>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Overview<\/strong><\/h2>\n<p>Adjunctive analgesic in animals, it provides analgesia through NMDA antagonist action which may potentiate the effects of other analgesics.<\/p>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Uses of Amantadine<\/strong><strong style=\"color: var(--td_text_color, #111111); font-family: var(--td_default_google_font_2, 'Roboto', sans-serif);\"> For Dogs and Cats<\/strong><\/h2>\n<ul>\n<li><strong>Dogs and Cats<\/strong>: Effective as an adjunctive analgesic for animals unresponsive to opioids or needing long-term pain management alongside NSAIDs. It is often used for osteoarthritis and cancer-related pain.<\/li>\n<li><strong>Horses<\/strong>: Can be used to manage chronic pain when other analgesics do not suffice.<\/li>\n<li><strong>Other Species<\/strong>: While less common, amantadine has potential applications in exotic animals for chronic pain, pending species-specific evaluation.<\/li>\n<\/ul>\n<div class='code-block code-block-20' style='margin: 8px auto; text-align: center; display: block; clear: both;'>\n<a href=\"https:\/\/www.vet-ebooks.com\/premium-memberships\/\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17003\" src=\"https:\/\/www.vet-ebooks.com\/wp-content\/uploads\/2024\/10\/veterinary-books-1.jpg\" width=\"480\" height=\"98\"  alt=\"Vet Books\"\/><\/a><\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Amantadine Dose\u00a0For Dogs, Cats and Horses<\/strong><\/h2>\n<p><strong>Amantadine Doses For Dogs and Cats:<\/strong><\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 10px 0; background-color: #f2f2f2; border: 1px solid #999;\">\n<thead>\n<tr style=\"background-color: #fabd14; color: #fff; font-family: sans-serif;\">\n<th style=\"padding: 8px; border: 1px solid #999;\">Species<\/th>\n<th style=\"padding: 8px; border: 1px solid #999;\">Condition<\/th>\n<th style=\"padding: 8px; border: 1px solid #999;\">Dosage &amp; Notes<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\" rowspan=\"2\"><strong>Dogs<\/strong><\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">Chronic Pain\/Osteoarthritis<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">3\u20135 mg\/kg PO q24h. For severe cases, consider dividing the dose q12h.<br \/>\n<strong>Note:<\/strong> Administer with food to minimize GI upset. Monitor for any signs of GI distress or behavioral changes.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\">Adjunctive Pain Management (Cancer)<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">3\u20135 mg\/kg PO q24h. Adjust dose based on patient response. Regularly assess for effectiveness and side effects.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\" rowspan=\"2\"><strong>Cats<\/strong><\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">Chronic Pain\/Osteoarthritis<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">1\u20134 mg\/kg PO q24h. Start at the lower end and increase gradually.<br \/>\n<strong>Note:<\/strong> Monitor for GI side effects and behavioral changes, especially during dose adjustments. Administer with food for better tolerance.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\">Adjunctive Pain Management (Cancer)<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">1\u20134 mg\/kg PO q24h. Adjust based on clinical response and tolerance. Regular check-ups are recommended to evaluate ongoing efficacy and side effects.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\"><strong>Horses<\/strong><\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">Chronic Pain<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">2\u20134 mg\/kg PO q24h. Adjust as necessary for optimal pain control.<br \/>\n<strong>Note:<\/strong> Ensure regular monitoring for signs of GI discomfort or behavioral changes. Gradual dose adjustments may be beneficial for improved tolerance.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\"><strong>Small Mammals<\/strong><\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">Chronic Pain<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">Refer to species-specific guidelines; typical range is 1\u20135 mg\/kg PO q24h.<br \/>\n<strong>Note:<\/strong> Start with lower dosages and adjust based on clinical feedback. Monitor closely for any signs of adverse reactions.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div class='code-block code-block-30' style='margin: 8px 0; clear: both;'>\n <html>\n  <head>\n    <style>\n    \n \n      #calculator {\n        width: 100%;\n        margin: auto;\n      }\n      \n      @media (max-width: 600px) {\n        #calculator {\n          width: 90%;\n        }\n      }\n      \n      #calculator23 {\n        display: block;\n        margin-bottom: 8px;\n        font-size: 14px;\nfont-family: sans-serif;font-weight:600;\n      }\n      \n      #calculator24{\n        width: 100%;\n        padding: 12px 20px;\n        margin: 8px 0;\n        box-sizing: border-box;\n        border: 2px solid #ccc;\n        border-radius: 4px;\n      }\n      \n      #calculator25 {\n        width: 100%;\n    background-color: #fabd14;\n    color: white;\n    padding: 11px 18px;\n    margin: 5px 0;\n    border: none;\n    border-radius: 4px;\n    cursor: pointer;\n    font-size: 15px;\n    font-family: sans-serif;\n    font-weight: 600;\n}\n      }\n      \n      #result {\n        font-size: 18px;\n        font-weight: bold;\n      }\n    <\/style>\n  <\/head>\n  <body>\n  \n \n\n  <h2 style=\"border-bottom: 2px #fabd14 solid;font-size: 20px;\" id=\"cd-understanding\" class=\"cd-section-title\"><span><strong>Drug Dosage Calculator<\/strong><\/span><\/h2>\n    <form id=\"calculator\">\n      <label id=\"calculator23\" for=\"weight\">Animal Weight (kg):<\/label>\n      <input type=\"text\" id=\"weight\" name=\"weight\" id=\"calculator24\">\n      <label for=\"dose\" id=\"calculator23\">Drug Dose (mg\/kg):<\/label>\n      <input type=\"text\" id=\"dose\" name=\"dose\" id=\"calculator24\">\n      <label for=\"concentration\" id=\"calculator23\">Drug Concentration (mg\/mL or mg\/tablet):<\/label>\n      <input type=\"text\" id=\"concentration\" name=\"concentration\" id=\"calculator24\">\n      <button type=\"button\" onclick=\"calculate()\" id=\"calculator25\">Calculate<\/button>\n    <\/form> \n    \n    <p style=\"\n    font-size: 13px;\n    font-weight: 600;\n    font-family: sans-serif;\n    background: #444;\n    padding: 5px;\n    border-radius: 5px;\n    color: #fff;\n\">You Should Give: <span id=\"result\"><\/span><\/p>\n\n\n    \n    <script>\n      function calculateDose(weight, dose, concentration) {\n        return (weight * dose \/ concentration).toFixed(2);\n      }\n      \n      function calculate() {\n        let weight = document.getElementById(\"weight\").value;\n        let dose = document.getElementById(\"dose\").value;\n        let concentration = document.getElementById(\"concentration\").value;\n        let result = calculateDose(weight, dose, concentration);\n        document.getElementById(\"result\").innerHTML = result + \" mL or tablet \";\n      }\n    <\/script>\n  <\/body>\n<\/html>\n<\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Common Side Effects of Amantadine<\/strong><\/h2>\n<ul>\n<li><strong>Dogs<\/strong>: May develop agitation, flatulence, loose stools, or diarrhea, particularly in the initial stages of treatment.<\/li>\n<li><strong>Cats<\/strong>: Common side effects include GI upset (e.g., vomiting, diarrhea) and occasional behavioral changes like restlessness or increased vocalization.<\/li>\n<li><strong>Horses and Other Species<\/strong>: Mild GI effects or behavioral changes may occur, though specific data is limited.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Contraindications of Amantadine<\/strong><\/h2>\n<ul>\n<li>Amantadine should be used with caution in animals with:\n<ol>\n<li><strong>Hepatic or Renal Disease<\/strong>: Due to its excretion profile, reduced function may alter drug clearance.<\/li>\n<li><strong>Congestive Heart Failure<\/strong>: Risk of exacerbating cardiac symptoms.<\/li>\n<li><strong>Seizure Disorders<\/strong>: May lower the seizure threshold.<\/li>\n<li><strong>Untreated Angle-Closure Glaucoma<\/strong>: Increased intraocular pressure risk.<\/li>\n<li><strong>Active Psychoses or Severe CNS Disorders<\/strong>: May worsen symptoms.<\/li>\n<li><strong>Eczematoid Dermatitis<\/strong>: Use cautiously, as underlying conditions may be exacerbated.<\/li>\n<\/ol>\n<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Some Notes:<\/strong><\/h2>\n<ol>\n<li><strong>Drug Interactions<\/strong>:\n<ul>\n<li><strong>Anticholinergic Agents (e.g., atropine)<\/strong>: May enhance anticholinergic effects, increasing risk for side effects like dry mouth or constipation.<\/li>\n<li><strong>Tramadol<\/strong>: Combined use may increase the risk of seizures, especially at higher doses.<\/li>\n<li><strong>Urinary Acidifiers<\/strong>: Drugs like ammonium chloride or methionine can decrease the efficacy of amantadine by enhancing renal excretion.<\/li>\n<li><strong>Cyclosporine<\/strong>: Potential increase in cyclosporine concentrations, necessitating monitoring.<\/li>\n<li><strong>Cyclophosphamide<\/strong>: May heighten the risk of bone marrow suppression.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Monitoring<\/strong>:\n<ul>\n<li>Regularly check for GI side effects, signs of CNS disturbance, or behavioral changes.<\/li>\n<li>Periodic evaluation of renal and liver function is recommended, especially with long-term use.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Overdose Management<\/strong>:\n<ul>\n<li>Signs of overdose include tremors, ataxia, hypersalivation, and seizures.<\/li>\n<li>Supportive treatment is advised, with consultation from veterinary poison control centers if needed.<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Amantadine for Dogs, Cats and Horses: Dosage, Uses, and Side Effects Guide Overview Adjunctive analgesic in animals, it provides analgesia through NMDA antagonist action which may potentiate the effects of other analgesics. Uses of Amantadine For Dogs and Cats Dogs and Cats: Effective as an adjunctive analgesic for animals unresponsive to opioids or needing long-term [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1017,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[24],"class_list":["post-163","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-analgesics","tag-nmda-antagonist"],"_links":{"self":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/163","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/comments?post=163"}],"version-history":[{"count":0,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/163\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media\/1017"}],"wp:attachment":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media?parent=163"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/categories?post=163"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/tags?post=163"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}