{"id":150,"date":"2023-01-20T19:18:11","date_gmt":"2023-01-20T17:18:11","guid":{"rendered":"https:\/\/www.vetdrugslist.com\/?p=150"},"modified":"2025-05-17T01:37:34","modified_gmt":"2025-05-16T22:37:34","slug":"alfaxalone-dose","status":"publish","type":"post","link":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/alfaxalone-dose\/","title":{"rendered":"Alfaxalone"},"content":{"rendered":"<p style=\"text-align: center; font-size: 24px; font-family: sans-serif;\"><strong>Alfaxalone for Dogs, Cats, Equine, and All Animals: Dosage, Uses, and Side Effects Guide<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-114 aligncenter\" src=\"https:\/\/www.vet-ebooks.com\/wp-content\/uploads\/2024\/10\/alfaxalone-dosage-uses-and-side-effects.jpg\" alt=\"Alfaxalone for Dogs, Cats, Equine, and All Animals: Dosage, Uses, and Side Effects Guide\" width=\"578\" height=\"347\" \/><\/p>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Overview<\/strong><\/h2>\n<p>Alfaxalone is a <strong>neuroactive steroid anesthetic<\/strong> with no analgesic properties. It acts by modulating <strong>GABA receptors<\/strong>, leading to <strong>CNS depression<\/strong> and anesthesia. Its fast onset and rapid recovery make it suitable for <strong>induction and maintenance of anesthesia<\/strong> across multiple veterinary species.<\/p>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Uses of Alfaxalone<\/strong><\/h2>\n<ul>\n<li><strong>Dogs<\/strong>:\n<ul>\n<li>Induction and maintenance of general anesthesia.<\/li>\n<li>Suitable for <strong>anesthesia in sighthounds<\/strong>.<\/li>\n<li>Used for <strong>laryngeal motion assessment<\/strong> during anesthesia.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Cats<\/strong>:\n<ul>\n<li>Sedation, induction, and maintenance of anesthesia.<\/li>\n<li>Ideal for <strong>high-risk patients<\/strong> (e.g., geriatric or critical cases).<\/li>\n<li>Facilitates <strong>echocardiography<\/strong> without altering cardiac parameters.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Ferrets<\/strong>: Induction of general anesthesia.<\/li>\n<li><strong>Goats and Rabbits<\/strong>: For sedation or anesthesia maintenance.<\/li>\n<li><strong>Horses<\/strong>: Total Intravenous Anesthesia (TIVA) protocols for short field procedures.<\/li>\n<\/ul>\n<div class='code-block code-block-20' style='margin: 8px auto; text-align: center; display: block; clear: both;'>\n<a href=\"https:\/\/www.vet-ebooks.com\/premium-memberships\/\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17003\" src=\"https:\/\/www.vet-ebooks.com\/wp-content\/uploads\/2024\/10\/veterinary-books-1.jpg\" width=\"480\" height=\"98\"  alt=\"Vet Books\"\/><\/a><\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Alfaxalone Dose For Dogs, Cats, Equine, and All Animals<\/strong><\/h2>\n<table style=\"width: 100%; border-collapse: collapse; margin: 10px 0; background-color: #f2f2f2; border: 1px solid #999;\">\n<thead>\n<tr style=\"background-color: #fabd14; color: #fff; font-family: sans-serif;\">\n<th style=\"padding: 8px; border: 1px solid #999;\">Species<\/th>\n<th style=\"padding: 8px; border: 1px solid #999;\">Condition<\/th>\n<th style=\"padding: 8px; border: 1px solid #999;\">Dosage &amp; Notes<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\" rowspan=\"3\"><strong>Dogs<\/strong><\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">Induction of anesthesia<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">1.5\u20134.5 mg\/kg IV without premedication; 1.1\u20132 mg\/kg IV with premedication.<br \/>\n<strong>Note:<\/strong> Slow IV injection recommended to prevent respiratory depression.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\">Maintenance of anesthesia<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">1.2\u20132.2 mg\/kg IV bolus every 10 min, or constant rate infusion : 6\u20139 mg\/kg\/hour.<br \/>\n<strong>Note:<\/strong> Reduces the need for inhalation anesthetics by up to 50%.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\">Short procedures (IM sedation)<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">0.5\u20131 mg\/kg IM with methadone.<br \/>\n<strong>Note:<\/strong> Oxygen supplementation is advised.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\" rowspan=\"3\"><strong>Cats<\/strong><\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">Induction of anesthesia<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">2.2\u20139.7 mg\/kg IV; 2.3\u20133.6 mg\/kg IV with premedication.<br \/>\n<strong>Note:<\/strong> Use lower end of range for stable patients to prevent hypotension.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\">Maintenance of anesthesia<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">1.1\u20131.5 mg\/kg IV bolus every 10 min, or constant rate infusion : 7\u201310 mg\/kg\/hour.<br \/>\n<strong>Note:<\/strong> Avoid rapid infusion to prevent excitement during recovery.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\">Sedation for diagnostic procedures<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">2\u20133 mg\/kg IM with butorphanol.<br \/>\n<strong>Note:<\/strong> Ensure quiet recovery environment to prevent agitation.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\"><strong>Rabbits<\/strong><\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">Induction of anesthesia<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">6 mg\/kg IM with butorphanol and dexmedetomidine.<br \/>\n<strong>Note:<\/strong> Oxygen supplementation is advised during anesthesia.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\"><strong>Ferrets<\/strong><\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">Induction of anesthesia<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">2.5 mg\/kg IV with medetomidine 0.02 mg\/kg IM.<br \/>\n<strong>Note:<\/strong> Monitor heart rate to detect bradycardia during anesthesia.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\" rowspan=\"2\"><strong>Goats<\/strong><\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">Induction of anesthesia<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">2 mg\/kg IV with lidocaine; CRI: 6.7 mg\/kg\/hour.<br \/>\n<strong>Note:<\/strong> Premedicate with xylazine for smoother induction.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\">With xylazine premedication<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">2.3 mg\/kg IV.<br \/>\n<strong>Note:<\/strong> Ensure oxygen supply to prevent hypoxia during procedures.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\"><strong>Horses<\/strong><\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">TIVA protocol<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">1\u20132 mg\/kg IV with medetomidine, followed by CRI at 0.5\u20131.5 mg\/kg\/hour.<br \/>\n<strong>Note:<\/strong> Monitor closely for muscle tremors during recovery.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\"><strong>Cattle (Calves)<\/strong><\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">Sedation<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">1.2 mg\/kg IV after premedication with xylazine 0.1 mg\/kg IM.<br \/>\n<strong>Note:<\/strong> Monitor respiratory function closely during sedation.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div class='code-block code-block-30' style='margin: 8px 0; clear: both;'>\n <html>\n  <head>\n    <style>\n    \n \n      #calculator {\n        width: 100%;\n        margin: auto;\n      }\n      \n      @media (max-width: 600px) {\n        #calculator {\n          width: 90%;\n        }\n      }\n      \n      #calculator23 {\n        display: block;\n        margin-bottom: 8px;\n        font-size: 14px;\nfont-family: sans-serif;font-weight:600;\n      }\n      \n      #calculator24{\n        width: 100%;\n        padding: 12px 20px;\n        margin: 8px 0;\n        box-sizing: border-box;\n        border: 2px solid #ccc;\n        border-radius: 4px;\n      }\n      \n      #calculator25 {\n        width: 100%;\n    background-color: #fabd14;\n    color: white;\n    padding: 11px 18px;\n    margin: 5px 0;\n    border: none;\n    border-radius: 4px;\n    cursor: pointer;\n    font-size: 15px;\n    font-family: sans-serif;\n    font-weight: 600;\n}\n      }\n      \n      #result {\n        font-size: 18px;\n        font-weight: bold;\n      }\n    <\/style>\n  <\/head>\n  <body>\n  \n \n\n  <h2 style=\"border-bottom: 2px #fabd14 solid;font-size: 20px;\" id=\"cd-understanding\" class=\"cd-section-title\"><span><strong>Drug Dosage Calculator<\/strong><\/span><\/h2>\n    <form id=\"calculator\">\n      <label id=\"calculator23\" for=\"weight\">Animal Weight (kg):<\/label>\n      <input type=\"text\" id=\"weight\" name=\"weight\" id=\"calculator24\">\n      <label for=\"dose\" id=\"calculator23\">Drug Dose (mg\/kg):<\/label>\n      <input type=\"text\" id=\"dose\" name=\"dose\" id=\"calculator24\">\n      <label for=\"concentration\" id=\"calculator23\">Drug Concentration (mg\/mL or mg\/tablet):<\/label>\n      <input type=\"text\" id=\"concentration\" name=\"concentration\" id=\"calculator24\">\n      <button type=\"button\" onclick=\"calculate()\" id=\"calculator25\">Calculate<\/button>\n    <\/form> \n    \n    <p style=\"\n    font-size: 13px;\n    font-weight: 600;\n    font-family: sans-serif;\n    background: #444;\n    padding: 5px;\n    border-radius: 5px;\n    color: #fff;\n\">You Should Give: <span id=\"result\"><\/span><\/p>\n\n\n    \n    <script>\n      function calculateDose(weight, dose, concentration) {\n        return (weight * dose \/ concentration).toFixed(2);\n      }\n      \n      function calculate() {\n        let weight = document.getElementById(\"weight\").value;\n        let dose = document.getElementById(\"dose\").value;\n        let concentration = document.getElementById(\"concentration\").value;\n        let result = calculateDose(weight, dose, concentration);\n        document.getElementById(\"result\").innerHTML = result + \" mL or tablet \";\n      }\n    <\/script>\n  <\/body>\n<\/html>\n<\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Common Side Effects of Alfaxalone<\/strong><\/h2>\n<ul>\n<li><strong>Cardiorespiratory depression<\/strong>: Especially with rapid IV administration.<\/li>\n<li><strong>Apnea<\/strong>: Often following induction; supplemental oxygen may be needed.<\/li>\n<li><strong>Hypothermia<\/strong>: External warming is recommended during anesthesia.<\/li>\n<li><strong>Excitement during recovery<\/strong>: May manifest as <strong>vocalization, paddling, or tremors<\/strong>.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Contraindications of Alfaxalone<\/strong><\/h2>\n<ul>\n<li><strong>Known hypersensitivity<\/strong> to alfaxalone or its components.<\/li>\n<li>Avoid in animals with <strong>liver dysfunction<\/strong> or <strong>respiratory compromise<\/strong>.<\/li>\n<li><strong>Do not mix with other IV anesthetic agents<\/strong> (e.g., propofol) due to the risk of <strong>postinduction apnea<\/strong>.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Some Notes:<\/strong><\/h2>\n<ol>\n<li><strong>Monitoring Requirements<\/strong>:\n<ul>\n<li>Continuous monitoring of <strong>oxygen saturation (SpO2)<\/strong> and <strong>ventilatory status<\/strong> is essential.<\/li>\n<li>Administer <strong>pain control medications<\/strong> as alfaxalone provides no analgesia.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Drug Interactions<\/strong>:\n<ul>\n<li>Combined use with <strong>benzodiazepines, opioids, or alpha-2 agonists<\/strong> enhances the sedative effect.<\/li>\n<li>Avoid concurrent use with <strong>propofol or thiopental<\/strong> due to increased risk of <strong>CNS depression<\/strong>.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Recovery Tips<\/strong>:\n<ul>\n<li>Recovery should occur in a <strong>quiet, low-stimulation environment<\/strong>.<\/li>\n<li><strong>Preanesthetic drugs<\/strong> like benzodiazepines can reduce excitement during recovery.<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Alfaxalone for Dogs, Cats, Equine, and All Animals: Dosage, Uses, and Side Effects Guide Overview Alfaxalone is a neuroactive steroid anesthetic with no analgesic properties. It acts by modulating GABA receptors, leading to CNS depression and anesthesia. Its fast onset and rapid recovery make it suitable for induction and maintenance of anesthesia across multiple veterinary [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1000,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[15],"class_list":["post-150","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-anesthesia","tag-intravenous-anesthetic"],"_links":{"self":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/150","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/comments?post=150"}],"version-history":[{"count":0,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/150\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media\/1000"}],"wp:attachment":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media?parent=150"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/categories?post=150"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/tags?post=150"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}