{"id":148,"date":"2023-01-19T19:18:11","date_gmt":"2023-01-19T17:18:11","guid":{"rendered":"https:\/\/www.vetdrugslist.com\/?p=148"},"modified":"2025-05-17T01:29:08","modified_gmt":"2025-05-16T22:29:08","slug":"alendronate-sodium-dose","status":"publish","type":"post","link":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/alendronate-sodium-dose\/","title":{"rendered":"Alendronate (Alendronate sodium)"},"content":{"rendered":"<p style=\"text-align: center; font-size: 24px; font-family: sans-serif;\"><strong>Alendronate for Dogs and Cats: Dosage, Uses, and Side Effects Guide<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-114 aligncenter\" src=\"https:\/\/www.vet-ebooks.com\/wp-content\/uploads\/2024\/10\/alendronate-dosage-uses-and-side-effects.jpg\" alt=\"Alendronate for Dogs and Cats: Dosage, Uses, and Side Effects Guide\" width=\"578\" height=\"347\" \/><\/p>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Overview<\/strong><\/h2>\n<p>Alendronate is a <strong>bisphosphonate<\/strong> that inhibits <strong>osteoclastic bone resorption<\/strong>, which helps manage conditions related to bone degradation and excessive calcium. It also inhibits <strong>angiogenesis, cancer cell division, and osteoclastogenesis<\/strong>, and induces <strong>apoptosis<\/strong> of osteoclasts.<\/p>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Uses of Alendronate In Dogs and Cats<\/strong><\/h2>\n<ul>\n<li><strong>Cats<\/strong>:\n<ul>\n<li>Treatment of <strong>idiopathic hypercalcemia<\/strong>.<\/li>\n<li>Management of <strong>feline tooth resorption<\/strong>.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Dogs<\/strong>:\n<ul>\n<li>Management of <strong>bone pain<\/strong> caused by <strong>osteolytic conditions<\/strong> (e.g., bone tumors or osteosarcoma).<\/li>\n<li>Adjunct therapy for <strong>hypercalcemia<\/strong>.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<div class='code-block code-block-20' style='margin: 8px auto; text-align: center; display: block; clear: both;'>\n<a href=\"https:\/\/www.vet-ebooks.com\/premium-memberships\/\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17003\" src=\"https:\/\/www.vet-ebooks.com\/wp-content\/uploads\/2024\/10\/veterinary-books-1.jpg\" width=\"480\" height=\"98\"  alt=\"Vet Books\"\/><\/a><\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Alendronate Dose For Dogs, Cats, Pigs, and Birds<\/strong><\/h2>\n<table style=\"width: 100%; border-collapse: collapse; margin: 10px 0; background-color: #f2f2f2; border: 1px solid #999;\">\n<thead>\n<tr style=\"background-color: #fabd14; color: #fff; family: sans-serif;\">\n<th style=\"padding: 8px; border: 1px solid #999;\">Species<\/th>\n<th style=\"padding: 8px; border: 1px solid #999;\">Condition Treated with Alendronate<\/th>\n<th style=\"padding: 8px; border: 1px solid #999;\">Dosage<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\" rowspan=\"3\"><strong>Dogs<\/strong><\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">Hypercalcemia<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">0.5\u20131 mg\/kg PO every 24 hours on an empty stomach<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\">Bone pain (e.g., osteosarcoma)<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">10 mg\/dog PO once daily<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\">Osteosarcoma management (extra-label)<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">2 mg\/kg PO once daily on an empty stomach<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\" rowspan=\"3\"><strong>Cats<\/strong><\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">Idiopathic hypercalcemia<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">5\u201310 mg\/cat PO weekly. Increase to 30 mg\/cat PO if well tolerated<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\">Tooth resorption<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">9 mg\/kg PO twice per week<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div class='code-block code-block-30' style='margin: 8px 0; clear: both;'>\n <html>\n  <head>\n    <style>\n    \n \n      #calculator {\n        width: 100%;\n        margin: auto;\n      }\n      \n      @media (max-width: 600px) {\n        #calculator {\n          width: 90%;\n        }\n      }\n      \n      #calculator23 {\n        display: block;\n        margin-bottom: 8px;\n        font-size: 14px;\nfont-family: sans-serif;font-weight:600;\n      }\n      \n      #calculator24{\n        width: 100%;\n        padding: 12px 20px;\n        margin: 8px 0;\n        box-sizing: border-box;\n        border: 2px solid #ccc;\n        border-radius: 4px;\n      }\n      \n      #calculator25 {\n        width: 100%;\n    background-color: #fabd14;\n    color: white;\n    padding: 11px 18px;\n    margin: 5px 0;\n    border: none;\n    border-radius: 4px;\n    cursor: pointer;\n    font-size: 15px;\n    font-family: sans-serif;\n    font-weight: 600;\n}\n      }\n      \n      #result {\n        font-size: 18px;\n        font-weight: bold;\n      }\n    <\/style>\n  <\/head>\n  <body>\n  \n \n\n  <h2 style=\"border-bottom: 2px #fabd14 solid;font-size: 20px;\" id=\"cd-understanding\" class=\"cd-section-title\"><span><strong>Drug Dosage Calculator<\/strong><\/span><\/h2>\n    <form id=\"calculator\">\n      <label id=\"calculator23\" for=\"weight\">Animal Weight (kg):<\/label>\n      <input type=\"text\" id=\"weight\" name=\"weight\" id=\"calculator24\">\n      <label for=\"dose\" id=\"calculator23\">Drug Dose (mg\/kg):<\/label>\n      <input type=\"text\" id=\"dose\" name=\"dose\" id=\"calculator24\">\n      <label for=\"concentration\" id=\"calculator23\">Drug Concentration (mg\/mL or mg\/tablet):<\/label>\n      <input type=\"text\" id=\"concentration\" name=\"concentration\" id=\"calculator24\">\n      <button type=\"button\" onclick=\"calculate()\" id=\"calculator25\">Calculate<\/button>\n    <\/form> \n    \n    <p style=\"\n    font-size: 13px;\n    font-weight: 600;\n    font-family: sans-serif;\n    background: #444;\n    padding: 5px;\n    border-radius: 5px;\n    color: #fff;\n\">You Should Give: <span id=\"result\"><\/span><\/p>\n\n\n    \n    <script>\n      function calculateDose(weight, dose, concentration) {\n        return (weight * dose \/ concentration).toFixed(2);\n      }\n      \n      function calculate() {\n        let weight = document.getElementById(\"weight\").value;\n        let dose = document.getElementById(\"dose\").value;\n        let concentration = document.getElementById(\"concentration\").value;\n        let result = calculateDose(weight, dose, concentration);\n        document.getElementById(\"result\").innerHTML = result + \" mL or tablet \";\n      }\n    <\/script>\n  <\/body>\n<\/html>\n<\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Common Side Effects of Alendronate In Dogs and Cats<\/strong><\/h2>\n<ul>\n<li><strong>Esophageal irritation or ulcers<\/strong>: Encourage drinking water post-dosing to minimize risks.<\/li>\n<li><strong>Gastrointestinal issues<\/strong>: Vomiting, inappetence, or anorexia.<\/li>\n<li><strong>Muscle and bone pain<\/strong>.<\/li>\n<li><strong>Hypocalcemia<\/strong>: Monitor calcium levels, particularly in patients receiving long-term treatment.<\/li>\n<li><strong>Osteonecrosis<\/strong> (rare, but reported in cats with prolonged use).<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Contraindications of Alendronate In Dogs and Cats<\/strong><\/h2>\n<ul>\n<li>Avoid use in animals with <strong>esophageal disease<\/strong> (e.g., esophagitis or stricture).<\/li>\n<li>Use cautiously in patients with <strong>renal insufficiency<\/strong>; avoid use in <strong>renal failure<\/strong>.<\/li>\n<li>Avoid concurrent use with <strong>calcium-containing supplements<\/strong> or medications, as they reduce alendronate\u2019s bioavailability.<\/li>\n<li><strong>Hypersensitivity to bisphosphonates<\/strong> is a contraindication.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Some Notes:<\/strong><\/h2>\n<ol>\n<li><strong>Administration Guidelines<\/strong>:\n<ul>\n<li>Administer on an empty stomach with <strong>water only<\/strong>. Food reduces absorption by 60%.<\/li>\n<li>Offer <strong>6 mL water<\/strong> by syringe post-administration to prevent esophageal irritation.<\/li>\n<li>For <strong>cats<\/strong>, butter the nasal planum to increase salivation and reduce esophageal transit time.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Drug Interactions<\/strong>:\n<ul>\n<li><strong>NSAIDs<\/strong> (e.g., meloxicam) may increase gastrointestinal risks.<\/li>\n<li><strong>Loop diuretics<\/strong> (e.g., furosemide) may increase the risk of <strong>hypocalcemia<\/strong>.<\/li>\n<li><strong>H2-receptor antagonists<\/strong> (e.g., ranitidine) increase alendronate levels.<\/li>\n<li>Avoid concurrent use with <strong>proton pump inhibitors<\/strong> (e.g., omeprazole) as they may reduce alendronate\u2019s effectiveness.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Monitoring Recommendations<\/strong>:\n<ul>\n<li>Monitor <strong>ionized calcium (iCa)<\/strong> levels regularly to maintain within the target range.<\/li>\n<li>Evaluate for <strong>GI side effects<\/strong> during follow-ups, especially with long-term use.<\/li>\n<li>Monthly monitoring is recommended during the first 6 months of therapy.<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Alendronate for Dogs and Cats: Dosage, Uses, and Side Effects Guide Overview Alendronate is a bisphosphonate that inhibits osteoclastic bone resorption, which helps manage conditions related to bone degradation and excessive calcium. It also inhibits angiogenesis, cancer cell division, and osteoclastogenesis, and induces apoptosis of osteoclasts. Uses of Alendronate In Dogs and Cats Cats: Treatment [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":998,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[13],"class_list":["post-148","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-musculoskeletal","tag-bone-resorption-inhibitor"],"_links":{"self":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/148","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/comments?post=148"}],"version-history":[{"count":0,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/148\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media\/998"}],"wp:attachment":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media?parent=148"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/categories?post=148"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/tags?post=148"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}