{"id":145,"date":"2023-01-19T19:18:11","date_gmt":"2023-01-19T17:18:11","guid":{"rendered":"https:\/\/www.vetdrugslist.com\/?p=145"},"modified":"2025-05-16T23:48:27","modified_gmt":"2025-05-16T20:48:27","slug":"aglepristone-dose","status":"publish","type":"post","link":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/aglepristone-dose\/","title":{"rendered":"Aglepristone"},"content":{"rendered":"<p style=\"text-align: center; font-size: 24px; font-family: sans-serif;\"><strong>Aglepristone for Dogs, Cats, Sheep, and Rabbits: Dosage, Uses, and Side Effects Guide<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-114 aligncenter\" src=\"https:\/\/www.vet-ebooks.com\/wp-content\/uploads\/2024\/10\/acetylcysteine-dosage-uses-and-side-effects.jpg\" alt=\"Aglepristone for Dogs, Cats, Sheep, and Rabbits: Dosage, Uses, and Side Effects Guide\" width=\"578\" height=\"347\" \/><\/p>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Overview<\/strong><\/h2>\n<p>An injectable solution, its action depends on the elimination of progesterone support for up to 7 days resulting from blocking progesterone receptors.<\/p>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Uses of Acetylcysteine\u00a0<\/strong><\/h2>\n<ul>\n<li><strong>Dogs:<\/strong>\n<ul>\n<li>Pregnancy termination up to 45 days post-mating.<\/li>\n<li>Treatment of <strong>pyometra<\/strong> (often combined with prostaglandin F analogs).<\/li>\n<li>Induction of <strong>parturition<\/strong> when combined with oxytocin.<\/li>\n<li>Treatment of <strong>insulin-resistant diabetes mellitus<\/strong> in intact bitches (alternative to ovariectomy).<\/li>\n<li>Management of <strong>benign vaginal tumors<\/strong>.<\/li>\n<li>Control of <strong>progesterone receptor-positive mammary carcinomas<\/strong>.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Cats:<\/strong>\n<ul>\n<li>Pregnancy termination (efficacy improves with misoprostol or cabergoline).<\/li>\n<li>Treatment of <strong>fibroadenomatous mammary hyperplasia<\/strong>.<\/li>\n<li>Management of <strong>pyometra<\/strong> with concurrent antibiotic therapy.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Sheep:<\/strong>\n<ul>\n<li><strong>Parturition induction<\/strong> and treatment of pregnancy toxemia.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Rabbits:<\/strong>\n<ul>\n<li><strong>Prevention of fetal implantation<\/strong> when administered early.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<div class='code-block code-block-20' style='margin: 8px auto; text-align: center; display: block; clear: both;'>\n<a href=\"https:\/\/www.vet-ebooks.com\/premium-memberships\/\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17003\" src=\"https:\/\/www.vet-ebooks.com\/wp-content\/uploads\/2024\/10\/veterinary-books-1.jpg\" width=\"480\" height=\"98\"  alt=\"Vet Books\"\/><\/a><\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Dose of Aglepristone\u00a0For Dogs, Cats, Sheep, and Rabbits<\/strong><\/h2>\n<p>Below are specific doses of Aglepristone for various conditions and species:<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 10px 0; background-color: #f2f2f2; border: 1px solid #999;\">\n<thead>\n<tr style=\"background-color: #fabd14; color: #fff; family: sans-serif;\">\n<th style=\"padding: 8px; border: 1px solid #999;\">Species<\/th>\n<th style=\"padding: 8px; border: 1px solid #999;\">Condition Treated with Aglepristone<\/th>\n<th style=\"padding: 8px; border: 1px solid #999;\">Dosage<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\" rowspan=\"6\"><strong>Dogs<\/strong><\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">Pregnancy termination (up to day 45)<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">10 mg\/kg SC, repeated after 24 hours<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\">Pyometra<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">10 mg\/kg SC on days 1, 2, and 7; additional doses on days 14 and 21 if needed<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\">Progesterone-induced acromegaly<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">10 mg\/kg SC every 7 days for three doses<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\">Insulin-resistant diabetes mellitus<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">10 mg\/kg SC on days 1, 2, 9, and 17 during the luteal phase, with PZI insulin<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\">Benign vaginal tumors<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">10 mg\/kg SC on days 1, 2, 8, 15, 28, and 35<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\">Mammary carcinomas (progesterone receptor-positive)<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">20 mg\/kg SC on days 1, 8, and 15<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\" rowspan=\"2\"><strong>Cats<\/strong><\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">Pregnancy termination<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">15 mg\/kg SC every 24 hours for two doses<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\">Mammary fibroadenomatous hyperplasia<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">20 mg\/kg SC every 7 days<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\"><strong>Sheep<\/strong><\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">Parturition induction<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">5\u201310 mg\/kg SC for two consecutive days<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px; border: 1px solid #999;\"><strong>Rabbits<\/strong><\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">Prevention of fetal implantation<\/td>\n<td style=\"padding: 8px; border: 1px solid #999;\">10 mg\/kg SC twice, 24 hours apart<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div class='code-block code-block-30' style='margin: 8px 0; clear: both;'>\n <html>\n  <head>\n    <style>\n    \n \n      #calculator {\n        width: 100%;\n        margin: auto;\n      }\n      \n      @media (max-width: 600px) {\n        #calculator {\n          width: 90%;\n        }\n      }\n      \n      #calculator23 {\n        display: block;\n        margin-bottom: 8px;\n        font-size: 14px;\nfont-family: sans-serif;font-weight:600;\n      }\n      \n      #calculator24{\n        width: 100%;\n        padding: 12px 20px;\n        margin: 8px 0;\n        box-sizing: border-box;\n        border: 2px solid #ccc;\n        border-radius: 4px;\n      }\n      \n      #calculator25 {\n        width: 100%;\n    background-color: #fabd14;\n    color: white;\n    padding: 11px 18px;\n    margin: 5px 0;\n    border: none;\n    border-radius: 4px;\n    cursor: pointer;\n    font-size: 15px;\n    font-family: sans-serif;\n    font-weight: 600;\n}\n      }\n      \n      #result {\n        font-size: 18px;\n        font-weight: bold;\n      }\n    <\/style>\n  <\/head>\n  <body>\n  \n \n\n  <h2 style=\"border-bottom: 2px #fabd14 solid;font-size: 20px;\" id=\"cd-understanding\" class=\"cd-section-title\"><span><strong>Drug Dosage Calculator<\/strong><\/span><\/h2>\n    <form id=\"calculator\">\n      <label id=\"calculator23\" for=\"weight\">Animal Weight (kg):<\/label>\n      <input type=\"text\" id=\"weight\" name=\"weight\" id=\"calculator24\">\n      <label for=\"dose\" id=\"calculator23\">Drug Dose (mg\/kg):<\/label>\n      <input type=\"text\" id=\"dose\" name=\"dose\" id=\"calculator24\">\n      <label for=\"concentration\" id=\"calculator23\">Drug Concentration (mg\/mL or mg\/tablet):<\/label>\n      <input type=\"text\" id=\"concentration\" name=\"concentration\" id=\"calculator24\">\n      <button type=\"button\" onclick=\"calculate()\" id=\"calculator25\">Calculate<\/button>\n    <\/form> \n    \n    <p style=\"\n    font-size: 13px;\n    font-weight: 600;\n    font-family: sans-serif;\n    background: #444;\n    padding: 5px;\n    border-radius: 5px;\n    color: #fff;\n\">You Should Give: <span id=\"result\"><\/span><\/p>\n\n\n    \n    <script>\n      function calculateDose(weight, dose, concentration) {\n        return (weight * dose \/ concentration).toFixed(2);\n      }\n      \n      function calculate() {\n        let weight = document.getElementById(\"weight\").value;\n        let dose = document.getElementById(\"dose\").value;\n        let concentration = document.getElementById(\"concentration\").value;\n        let result = calculateDose(weight, dose, concentration);\n        document.getElementById(\"result\").innerHTML = result + \" mL or tablet \";\n      }\n    <\/script>\n  <\/body>\n<\/html>\n<\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Side Effects of Aglepristone\u00a0For Dogs, Cats, Sheep, and Rabbits<\/strong><\/h2>\n<ul>\n<li>Local injection site reactions (pain, swelling, edema, skin thickening).<\/li>\n<li>Gastrointestinal symptoms (anorexia, diarrhea).<\/li>\n<li>Uterine infections (rare).<\/li>\n<li>Tachycardia reported in cats.<\/li>\n<li>Brown mucoid discharge 24 hours before fetal expulsion during pregnancy termination.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Contraindications of Aglepristone\u00a0For Dogs, Cats, Sheep, and Rabbits<\/strong><\/h2>\n<ul>\n<li>Avoid use in animals with suspected <strong>hypoadrenocorticism<\/strong>.<\/li>\n<li>Not recommended for animals with <strong>hepatic or renal impairment<\/strong>.<\/li>\n<li>Contraindicated in animals with <strong>chronic obstructive airway disease<\/strong> or <strong>cardiovascular conditions<\/strong>.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Some Notes:<\/strong><\/h2>\n<ol>\n<li><strong>Injection Handling: <\/strong>Administer no more than 5 ml per injection site. Use the scruff of the neck for injection and massage the site after administration to prevent reactions.<\/li>\n<li><strong>Pregnancy Termination Considerations:<\/strong>\n<ul>\n<li>When used after day 20 of pregnancy, physiological signs of parturition may occur, including mammary congestion and lactation.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Drug Interactions:<\/strong>\n<ul>\n<li>Concurrent use with <strong>glucocorticoids<\/strong> may reduce the efficacy of each drug.<\/li>\n<li>Interaction with <strong>azole antifungals<\/strong> (e.g., ketoconazole) is possible due to inhibition of CYP3A pathways\u200b<\/li>\n<\/ul>\n<\/li>\n<li><strong>Monitoring:<\/strong>\n<ul>\n<li>Monitor pregnancy termination with <strong>ultrasonography<\/strong> 10 days after treatment.<\/li>\n<li>Evaluate for signs of <strong>pyometra resolution<\/strong> via physical exam and bloodwork.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Human Safety: <\/strong>This product must not be handled by pregnant women due to the risk of accidental abortion.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Aglepristone for Dogs, Cats, Sheep, and Rabbits: Dosage, Uses, and Side Effects Guide Overview An injectable solution, its action depends on the elimination of progesterone support for up to 7 days resulting from blocking progesterone receptors. Uses of Acetylcysteine\u00a0 Dogs: Pregnancy termination up to 45 days post-mating. Treatment of pyometra (often combined with prostaglandin F [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":984,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12],"tags":[11],"class_list":["post-145","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reproductive-hormones","tag-progesterone-receptor-antagonist"],"_links":{"self":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/145","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/comments?post=145"}],"version-history":[{"count":0,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/145\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media\/984"}],"wp:attachment":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media?parent=145"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/categories?post=145"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/tags?post=145"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}