{"id":1200,"date":"2023-05-01T01:25:20","date_gmt":"2023-05-01T01:25:20","guid":{"rendered":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/?p=1200"},"modified":"2023-05-01T01:26:52","modified_gmt":"2023-05-01T01:26:52","slug":"domperidone","status":"publish","type":"post","link":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/domperidone\/","title":{"rendered":"Domperidone"},"content":{"rendered":"<p style=\"text-align: center; font-size: 24px; font-family: sans-serif;\"><strong>Domperidone: Uses, Dosage and Side Effects<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-1396 aligncenter\" src=\"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/04\/Domperidone-1.jpg\" alt=\"Domperidone: Uses, Dosage and Side Effects\" width=\"658\" height=\"395\" srcset=\"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/04\/Domperidone-1.jpg 800w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/04\/Domperidone-1-300x180.jpg 300w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/04\/Domperidone-1-768x461.jpg 768w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/04\/Domperidone-1-696x418.jpg 696w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/04\/Domperidone-1-700x420.jpg 700w\" sizes=\"auto, (max-width: 658px) 100vw, 658px\" \/><\/p>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Overview<\/strong><\/h2>\n<ul>\n<li>Antiemetic with a mechanism of action similar to that of metoclopramide, but with fewer adverse CNS effects because it cannot cross the blood-brain barrier.<\/li>\n<li>It may not be prokinetic in canines, but it is gastrokinetic in humans.<\/li>\n<li>In addition, it has been demonstrated to enhance the innate cell-mediated immune response.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Uses of Domperidone<\/strong><\/h2>\n<ul>\n<li><strong>Treatment of vomiting<\/strong>; however, maropitant is authorized for veterinary use and there is more clinical experience with metoclopramide and ondansetron.<\/li>\n<li>A strategic domperidone-based treatment program has shown some efficacy in reducing the risk of developing clinical <strong>canine leishmaniosis<\/strong> in a high-prevalence area.<\/li>\n<\/ul>\n<div class='code-block code-block-12' style='margin: 8px auto; text-align: center; display: block; clear: both;'>\n<a target=\"_blank\" href=\"https:\/\/www.vet-ebooks.com\/premium-memberships\/\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-17003\" src=\"https:\/\/www.vet-ebooks.com\/wp-content\/uploads\/2024\/10\/veterinary-books-1.jpg\" width=\"480\" height=\"98\"  alt=\"Vet Books\"\/><\/a><\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Dose of Domperidone in Dogs and Cats<\/strong><\/h2>\n<p><strong>Dogs:<\/strong><\/p>\n<ul>\n<li><strong>Vomiting:<\/strong> 2\u20135 mg per animal q8h.<\/li>\n<li>Preventive strategy for <strong>leishmaniosis<\/strong> in a high prevalence area: 0.5 mg\/kg q24h for 30 consecutive days, repeated every 4 months.<\/li>\n<\/ul>\n<p><strong>Cats: <\/strong><\/p>\n<ul>\n<li><strong>Vomiting:<\/strong> 2\u20135 mg per animal q8h.<\/li>\n<\/ul>\n<div class='code-block code-block-2' style='margin: 8px auto 8px 0; text-align: left; display: block; clear: both;'>\n <html>\n  <head>\n    <style>\n    \n \n      #calculator {\n        width: 100%;\n        margin: auto;\n      }\n      \n      @media (max-width: 600px) {\n        #calculator {\n          width: 90%;\n        }\n      }\n      \n      #calculator23 {\n        display: block;\n        margin-bottom: 8px;\n        font-size: 14px;\nfont-family: sans-serif;font-weight:600;\n      }\n      \n      #calculator24{\n        width: 100%;\n        padding: 12px 20px;\n        margin: 8px 0;\n        box-sizing: border-box;\n        border: 2px solid #ccc;\n        border-radius: 4px;\n      }\n      \n      #calculator25 {\n        width: 100%;\n    background-color: #fabd14;\n    color: white;\n    padding: 11px 18px;\n    margin: 5px 0;\n    border: none;\n    border-radius: 4px;\n    cursor: pointer;\n    font-size: 15px;\n    font-family: sans-serif;\n    font-weight: 600;\n}\n      }\n      \n      #result {\n        font-size: 18px;\n        font-weight: bold;\n      }\n    <\/style>\n  <\/head>\n  <body>\n  \n \n\n  <h2 style=\"border-bottom: 2px #fff7e6 solid;\" class=\"cd-section-title\"><span><strong>Drug Dosage Calculator<\/strong><\/span><\/h2>\n    <form id=\"calculator\">\n      <label id=\"calculator23\" for=\"weight\">Animal Weight (kg):<\/label>\n      <input type=\"text\" id=\"weight\" name=\"weight\" id=\"calculator24\">\n      <label for=\"dose\" id=\"calculator23\">Drug Dose (mg\/kg):<\/label>\n      <input type=\"text\" id=\"dose\" name=\"dose\" id=\"calculator24\">\n      <label for=\"concentration\" id=\"calculator23\">Drug Concentration (mg\/mL or mg\/tablet):<\/label>\n      <input type=\"text\" id=\"concentration\" name=\"concentration\" id=\"calculator24\">\n      <button type=\"button\" onclick=\"calculate()\" id=\"calculator25\">Calculate<\/button>\n    <\/form> \n    \n    <p style=\"\n    font-size: 13px;\n    font-weight: 600;\n    font-family: sans-serif;\n    background: #444;\n    padding: 5px;\n    border-radius: 5px;\n    color: #fff;\n\">You Should Give: <span id=\"result\"><\/span><\/p>\n\n\n    \n    <script>\n      function calculateDose(weight, dose, concentration) {\n        return (weight * dose \/ concentration).toFixed(2);\n      }\n      \n      function calculate() {\n        let weight = document.getElementById(\"weight\").value;\n        let dose = document.getElementById(\"dose\").value;\n        let concentration = document.getElementById(\"concentration\").value;\n        let result = calculateDose(weight, dose, concentration);\n        document.getElementById(\"result\").innerHTML = result + \" mL or tablet \";\n      }\n    <\/script>\n  <\/body>\n<\/html>\n<\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Side Effects of Domperidone in Dogs and Cats<\/strong><\/h2>\n<ul>\n<li>This drug may cause<strong> gastroparesis<\/strong> in dogs.<\/li>\n<li>Causes <strong>galactorrhea<\/strong> by raising plasma prolactin.<\/li>\n<li>Domperidone is banned in the US because it <strong>prolongs the QT interval<\/strong> and increases the risk of cardiac arrhythmias and sudden cardiac death.<\/li>\n<li>Cats show dose-dependent <strong>excitation<\/strong>, <strong>aggressiveness<\/strong>, and <strong>motor impairment<\/strong>.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Contraindications of Domperidone in Dogs and Cats<\/strong><\/h2>\n<ul>\n<li><strong> Intestinal obstruction<\/strong> or perforation<\/li>\n<li><strong>severe hepatic impairment. <\/strong><\/li>\n<li>Contraindicated in humans with known existing prolongation of cardiac conduction intervals, significant electrolyte disturbances, or underlying cardiac disease, but no information is available for dogs and cats.<\/li>\n<li>Use with caution in <strong>dog breeds (e.g. collies)<\/strong> that may have MDR1 (ABCB1) mutations.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Some Notes:<\/strong><\/h2>\n<ul>\n<li>Do not use concurrently with Class 1A or Class III antiarrhythmics (e.g. amiodarone, sotalol), erythromycin or cisapride.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Domperidone: Uses, Dosage and Side Effects Overview Antiemetic with a mechanism of action similar to that of metoclopramide, but with fewer adverse CNS effects because it cannot cross the blood-brain barrier. It may not be prokinetic in canines, but it is gastrokinetic in humans. In addition, it has been demonstrated to enhance the innate cell-mediated [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":1394,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[21],"tags":[104],"class_list":["post-1200","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-gastrointestinal","tag-dopamine-2-antagonist"],"_links":{"self":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/1200","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/comments?post=1200"}],"version-history":[{"count":0,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/1200\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media\/1394"}],"wp:attachment":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media?parent=1200"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/categories?post=1200"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/tags?post=1200"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}