{"id":1194,"date":"2023-05-01T01:44:15","date_gmt":"2023-05-01T01:44:15","guid":{"rendered":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/?p=1194"},"modified":"2023-05-01T01:44:15","modified_gmt":"2023-05-01T01:44:15","slug":"dobutamine","status":"publish","type":"post","link":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/dobutamine\/","title":{"rendered":"Dobutamine"},"content":{"rendered":"<p style=\"text-align: center; font-size: 24px; font-family: sans-serif;\"><strong>Dobutamine: Uses, Dosage and Side Effects<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-1409\" src=\"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/04\/Dobutamine.jpg\" alt=\"Dobutamine: Uses, Dosage and Side Effects\" width=\"668\" height=\"401\" srcset=\"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/04\/Dobutamine.jpg 800w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/04\/Dobutamine-300x180.jpg 300w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/04\/Dobutamine-768x461.jpg 768w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/04\/Dobutamine-696x418.jpg 696w, https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-content\/uploads\/2023\/04\/Dobutamine-700x420.jpg 700w\" sizes=\"auto, (max-width: 668px) 100vw, 668px\" \/><\/p>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Overview<\/strong><\/h2>\n<ul>\n<li>Dobutamine is a <strong>synthetic catecholamine<\/strong> with direct beta-1 adrenergic agonist effects and mild beta-2 and alpha-1 adrenergic effects at standard dosages.<\/li>\n<li>Stimulation of the beta-1 adrenoreceptors of the heart is predominantly responsible for inotropy, while the chronotropic, arrhythmogenic, and vasodilatory effects are less pronounced.<\/li>\n<li>Dobutamine does not induce endogenous noradrenaline secretion.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Uses of Dobutamine<\/strong><\/h2>\n<ul>\n<li>It <strong>supports\u00a0myocardial function<\/strong> during anesthesia in hypotensive animals\u00a0when reduced myocardial contractility is suspected to be the primary cause.<\/li>\n<li><strong>Short-term inotropic support for heart failure<\/strong> related to systolic dysfunction (e.g., dilated cardiomyopathy), sepsis, and cardiogenic shock.<\/li>\n<\/ul>\n<div class='code-block code-block-12' style='margin: 8px auto; text-align: center; display: block; clear: both;'>\n<a target=\"_blank\" href=\"https:\/\/www.vet-ebooks.com\/premium-memberships\/\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-17003\" src=\"https:\/\/www.vet-ebooks.com\/wp-content\/uploads\/2024\/10\/veterinary-books-1.jpg\" width=\"480\" height=\"98\"  alt=\"Vet Books\"\/><\/a><\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Dose of Dobutamine in Dogs and Cats<\/strong><\/h2>\n<p><strong>Dogs:<\/strong><\/p>\n<ul>\n<li>The lower end of the dose range is 2.5\u20135 \u03bcg (micrograms)\/kg\/min i.v. by constant rate infusion.<\/li>\n<li>Start at the bottom end of the dose range and increase slowly until the desired effect is achieved.<\/li>\n<li>Higher-end dose ranges up to 20 \u03bcg\/kg\/min i.v. by constant rate infusion have<br \/>\nbeen reported.<\/li>\n<li>Adverse effects (tachycardia, arrhythmia) are commonly seen at doses &gt;10 \u03bcg\/kg\/min.<\/li>\n<li>Administer with an i.v. infusion pump or other i.v. flow controlling device.<\/li>\n<\/ul>\n<p><strong>Cats:<\/strong><\/p>\n<ul>\n<li>1\u20135 \u03bcg (micrograms)\/kg\/min i.v. by constant rate infusion.<\/li>\n<li>Start at the bottom end of the dose range and increase slowly until the desired effect is achieved.<\/li>\n<li>Adverse effects are commonly seen at doses &gt;2.5 \u03bcg\/kg\/min.<\/li>\n<li>Administer with an i.v. infusion pump or other i.v. flow controlling device.<\/li>\n<li>Doses over 5 \u03bcg\/kg\/min i.v. by constant rate infusion are reported; may cause seizures.<\/li>\n<\/ul>\n<div class='code-block code-block-2' style='margin: 8px auto 8px 0; text-align: left; display: block; clear: both;'>\n <html>\n  <head>\n    <style>\n    \n \n      #calculator {\n        width: 100%;\n        margin: auto;\n      }\n      \n      @media (max-width: 600px) {\n        #calculator {\n          width: 90%;\n        }\n      }\n      \n      #calculator23 {\n        display: block;\n        margin-bottom: 8px;\n        font-size: 14px;\nfont-family: sans-serif;font-weight:600;\n      }\n      \n      #calculator24{\n        width: 100%;\n        padding: 12px 20px;\n        margin: 8px 0;\n        box-sizing: border-box;\n        border: 2px solid #ccc;\n        border-radius: 4px;\n      }\n      \n      #calculator25 {\n        width: 100%;\n    background-color: #fabd14;\n    color: white;\n    padding: 11px 18px;\n    margin: 5px 0;\n    border: none;\n    border-radius: 4px;\n    cursor: pointer;\n    font-size: 15px;\n    font-family: sans-serif;\n    font-weight: 600;\n}\n      }\n      \n      #result {\n        font-size: 18px;\n        font-weight: bold;\n      }\n    <\/style>\n  <\/head>\n  <body>\n  \n \n\n  <h2 style=\"border-bottom: 2px #fff7e6 solid;\" class=\"cd-section-title\"><span><strong>Drug Dosage Calculator<\/strong><\/span><\/h2>\n    <form id=\"calculator\">\n      <label id=\"calculator23\" for=\"weight\">Animal Weight (kg):<\/label>\n      <input type=\"text\" id=\"weight\" name=\"weight\" id=\"calculator24\">\n      <label for=\"dose\" id=\"calculator23\">Drug Dose (mg\/kg):<\/label>\n      <input type=\"text\" id=\"dose\" name=\"dose\" id=\"calculator24\">\n      <label for=\"concentration\" id=\"calculator23\">Drug Concentration (mg\/mL or mg\/tablet):<\/label>\n      <input type=\"text\" id=\"concentration\" name=\"concentration\" id=\"calculator24\">\n      <button type=\"button\" onclick=\"calculate()\" id=\"calculator25\">Calculate<\/button>\n    <\/form> \n    \n    <p style=\"\n    font-size: 13px;\n    font-weight: 600;\n    font-family: sans-serif;\n    background: #444;\n    padding: 5px;\n    border-radius: 5px;\n    color: #fff;\n\">You Should Give: <span id=\"result\"><\/span><\/p>\n\n\n    \n    <script>\n      function calculateDose(weight, dose, concentration) {\n        return (weight * dose \/ concentration).toFixed(2);\n      }\n      \n      function calculate() {\n        let weight = document.getElementById(\"weight\").value;\n        let dose = document.getElementById(\"dose\").value;\n        let concentration = document.getElementById(\"concentration\").value;\n        let result = calculateDose(weight, dose, concentration);\n        document.getElementById(\"result\").innerHTML = result + \" mL or tablet \";\n      }\n    <\/script>\n  <\/body>\n<\/html>\n<\/div>\n\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Side Effects of Dobutamine in Dogs and Cats<\/strong><\/h2>\n<ul>\n<li>Due to the <strong>short duration of action<\/strong> of dobutamine, adverse effects such as tachycardia, arrhythmia, and hypertension can typically be managed by discontinuing drug infusion.<\/li>\n<li>With prolonged use, <strong>hypokalemia<\/strong> can develop; this can increase the risk of tachyarrhythmias.<\/li>\n<li>Additionally, complex ventricular arrhythmias are treatable with lidocaine.<\/li>\n<li>Use with caution in atrial fibrillation, as<strong> it may increase ventricular rate<\/strong>.<\/li>\n<li>Prior and concurrent digoxin treatment is recommended.<\/li>\n<li>Also possible are <strong>nausea, vomiting, and seizures<\/strong>, particularly in cats.<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Contraindications of Dobutamine in Dogs and Cats<\/strong><\/h2>\n<ul>\n<li>Avoid in patients with a cardiac outflow obstruction (e.g. aortic stenosis).<\/li>\n<\/ul>\n<h2 style=\"border-bottom: 2px #fabd14 solid; font-size: 20px;\"><strong>Some Notes:<\/strong><\/h2>\n<ul>\n<li>Patients with diabetes who are treated with dobutamine may require more insulin.<\/li>\n<li>If dobutamine is administered with beta-blockers such as propranolol, doxapram, or monoamine oxidase inhibitors (e.g. selegiline), systemic vascular resistance may increase.<\/li>\n<li>Use concurrently with halothane may increase the incidence of arrhythmias.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Dobutamine: Uses, Dosage and Side Effects Overview Dobutamine is a synthetic catecholamine with direct beta-1 adrenergic agonist effects and mild beta-2 and alpha-1 adrenergic effects at standard dosages. Stimulation of the beta-1 adrenoreceptors of the heart is predominantly responsible for inotropy, while the chronotropic, arrhythmogenic, and vasodilatory effects are less pronounced. Dobutamine does not induce [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":1409,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-1194","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cardiovascular"],"_links":{"self":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/1194","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/comments?post=1194"}],"version-history":[{"count":0,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/posts\/1194\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media\/1409"}],"wp:attachment":[{"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/media?parent=1194"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/categories?post=1194"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vet-ebooks.com\/vetdrugslist\/wp-json\/wp\/v2\/tags?post=1194"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}